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      ["post_content"]=>
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Accompagnement de projets CNES
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2019 - ...
[/et_pb_blurb][et_pb_blurb title="Etat d'avancement :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.5" _module_preset="default" header_text_color="#444444" custom_margin="|8px||||" animation="off" locked="off" global_colors_info="{}"]
En cours                             
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.24.0" _module_preset="default" header_text_color="#444444" custom_margin="|-17px||||" animation="off" locked="off" global_colors_info="{}"]
Apporter un support et une expertise en physiologie pour la réalisation de projets menés par le CNES
[/et_pb_blurb][et_pb_blurb title="Partenaires :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.24.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
CNES
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ECHOFINDER
Assistant échographique autonome
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Depuis 1982, l’échographie est la seule technique d’imagerie disponible à bord des vols spatiaux habités. Elle est largement utilisée pour soutenir la recherche scientifique et la surveillance médicale des phénomènes physiologiques induits par la microgravité. Mais les contraintes liées aux futurs vols spatiaux (durée accrue, éloignement, temps de communication...) nécessitent de nouveaux systèmes médicaux pour assister les astronautes lors des séances d’échographie.
C’est dans ce cadre-là que le CNES a développé EchoFinder, un assistant à la réalisation d’images échographiques en complète autonomie et sans expertise médicale.
Depuis 2019, MEDES accompagne ainsi le CNES dans la réalisation et le suivi de ce projet très prometteur.
Echofinder est composé d’un système de réalité augmentée qui fournit un guidage en temps réel vers un positionnement idéal de la sonde préalablement enregistré. En parallèle, un processus de vision par ordinateur composé à la fois d’une analyse d’image physique et d’une solution basée sur l’apprentissage automatique permet de détecter et segmenter les organes ciblés. Le logiciel de réalité augmentée a notamment été testé au sol et lors d’une campagne de vol parabolique.
Aujourd’hui, une solution complète et fonctionnelle fonctionnant sur une tablette est proposée.
 
Projet CNES, en partenariat avec Sonoscanner, SFR, Université Paris Descartes, Vermon, CERCOM-Université de Tours et MEDES.
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PHYSIOTOOL
Nouvelle instrumentation de physiologie pour l'ISS
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Le CNES mène le projet dont l’objectif est de réaliser une étude de faisabilité ayant pour but la définition d’une nouvelle instrumentation de physiologie à bord du module Columbus de l’ISS (Station spatiale Internationale).
Celle-ci se veut versatile et regroupera des instruments destinés à l’étude des systèmes cardiovasculaire, musculaire et métabolique ainsi qu’à des expériences en neurosciences.
La possibilité de couplage avec d’autres instruments déjà déployés, tels que le système EveryWear ou un échographe, est également évaluée.
Dans un premier temps, cette instrumentation pourra être utilisée à bord de l’ISS jusqu’à 2025 voire 2028. Elle pourra être implémentée dans l’EPM (Euopean Physiology Modul), ou rester indépendante de ce module. Son champ d’application pourra ensuite s’étendre aux explorations spatiales sur la Lune et sur Mars.
MEDES accompagne le CNES dans la mise en oeuvre de son projet en apportant son expertise et savoir-faire en médecine et physiologie spatiales.
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Pour aller plus loin
 
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En savoir plus sur les activités du CNES ?
 
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En savoir plus sur les activités du CADMOS, centre du CNES, pour lequel MEDES apporte son support
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2017 - ...
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En cours
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Solution logicielle de suivi médical et nutritionnel de l'astronaute
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MEDES, CNES, ESA, NASA
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Développée pour le CNES dans le cadre de la mission Proxima, l’application logicielle Everywear assure un suivi médical et nutritionnel des astronautes à bord de l’ISS.
Couplée à un ensemble de capteurs biomédicaux, cette application est assimilable à un véritable assistant, matérialisé par une simple application sur tablette tactile.
Cette application a été un réel succès et est utilisée de manière pérenne dans la station.
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Everywear, assistant de l'astronaute
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EveryWear est une application mobile évolutive grâce à laquelle il est possible de collecter des données médicales et scientifiques directement à partir des capacités offertes par l’iPad que les astronautes ont avec eux à bord de la station ou/et à l’aide d’un ensemble de capteurs connectés. 
Elle sert notamment à assurer le suivi nutritionnel des astronautes, l’exécution d’expériences de physiologie via des questionnaires et l’échange de messages privés entre les astronautes et les équipes médicales au sol.
Cette application, très appréciée des astronautes pour ses fonctionnalités, son ergonomie et sa simplicité d’utilisation quotidienne, est un réel succès opérationnel et est aujourd’hui utilisée par les astronautes européens pour le support médical et par les astronautes de toutes les agences lorsqu’ils sont engagés dans la dizaine d’expériences en cours qui font appel à EveryWear. Au sol EveryWear est actuellement utilisé dans 3 USOCs (CADMOS, ECOS, BIOTESC) ainsi que par l’équipe médicale de l’EAC.
 
Everywear a notamment été utilisé lors des missions Proxima puis Alpha de Thomas Pesquet.
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Une coopération qui s'élargit
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Suite aux différents retours positifs, les agences ont formulé l’intérêt de soutenir le projet EveryWear pour la suite des missions ISS et l’envisagent pour les futures missions Orion et Gateway.
Une coopération ESA/CNES/NASA a ainsi été signée pour poursuivre le développement d’évolutions pour les missions en cours et développer des évolutions à la demande de la NASA dans le cadre du développement du common tool
EveryWear devient le hub central de collecte de données pour l’Exploration Medical System de l’ESA.
MEDES continue d'apporter son support sur ce projet pour les agences spatiales et de coordonner et réaliser les développements techniques.
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Everywear a reçu le prix d'honneur NASA Group Achievement Award (GAA) pour le développement de l’application Everywear Nutrition visant à collecter des informations nutritionnelles pour l’équipage 4 de la Station spatiale internationale. 
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MEDES, partenaire technique
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En tant qu'intervenant technique principal, MEDES a développé dans le cadre du projet :






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Pour aller plus loin
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2020 - ...
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En cours
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Réalisation d'une application mobile destinée 
à prévenir la perte d'autonomie des séniors
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OMS, ARS, CHU Toulouse, Gérontopole Toulouse, 
MEDES (partenaire technique)
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MEDES a été sollicité par le Gérontopôle du CHU de Toulouse, centre collaborateur de l’OMS sur la fragilité, en collaboration avec l’Agence Régionale de Santé Occitanie, pour la réalisation technique de l'application mobile ICOPE MONITOR.
Le programme ICOPE vise à préserver les capacités de nos aînés en repérant les premiers signes de fragilité et en offrant des solutions pour y remédier. L'objectif est qu'en étant acteur de sa santé, chaque senior puisse préserver son autonomie plus longtemps et retarder son entrée en dépendance.
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Le dispositif ICOPE
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L’objectif du programme ICOPE est de permettre au plus grand nombre de vieillir en bonne santé. En tant que Centre Collaborateur de l’O.M.S pour la Fragilité, la Recherche Clinique et la formation en Gériatrie, le Gérontopôle du CHU de Toulouse a ainsi implémenté le programme ICOPE dans la Région Occitanie avec pour objectif d’évaluer 200 000 séniors d’ici 5 ans et de promouvoir le vieillissement en bonne santé en s’appuyant sur des outils numériques.
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L'objectif de ce dispositif est de prévenir la perte d'autonomie grâce à une application dédiée et permettant d’évaluer, en quelques minutes, le maintien des fonctions essentielles des personnes âgées, pour mieux prévenir leur déclin.
Six fonctions essentielles au maintien de l’indépendance et au vieillissement en bonne santé sont ainsi surveillées : mobilité, nutrition, vision, audition, humeur et cognition.
Ce programme de santé publique (destiné aux 60 ans et plus) consiste à favoriser une approche intégrée de la santé qui prend en compte les capacités de la personne, les pathologies associées, l’environnement et le mode de vie avec pour objectif de développer un plan de soins centré sur la personne, en considérant ses souhaits et ses aspirations. L’accent est mis sur le fait que le patient est acteur de la prise en charge et du suivi.
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MEDES, partenaire technique
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En tant qu'intervenant technique principal, MEDES a développé dans le cadre du projet :


La base de données qui centralise toutes les données gérées par le projet
Des Web services permettant à l'application mobile et au chatbot d'interroger la base de données (patients d'un professionnel donné) et de pousser les données collectées (enregistrement d'un professionnel de santé ou d'un patient, évaluations des patients) dans la base.
L'application mobile et le chatbot peuvent être utilisés par les professionnels ou les patients eux-mêmes.
Un système de notifications par mail permettant d'envoyer des informations sur le programme, sur les comptes utilisateurs, sur les résultats d'évaluation et des rappels aux patients à propos des suivis qu'ils doivent réaliser
Une application Web, accessible uniquement par les professionnels de santé, permettant de :

Collecter les données d'évaluation des patients
Suivre les patients
D'administrer le système et ses utilisateurs (administrateurs seulement)
D'afficher des indicateurs d'activité et des statistiques
D'exporter les données afin de réaliser des statistiques plus poussées (administrateurs seulement)
D'exporter la liste des actes pouvant être soumis à la facturation (administrateurs seulement)


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Quelques chiffres
(Novembre 2022)
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Pour aller plus loin
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Brochure de présentation du programme ICOPE
ICOPE MONITOR, une application pour prévenir le déclin des fonctions chez les personnes âgées - Article CHU Toulouse
Le programme ICOPE - Article "Inspire, Vieillir en bonne santé"
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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BSGN LifeScience Industry Accelerator 
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2021 - ...
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En cours
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Accélération d'activités commerciales en orbite terrestre basse dans le domaine des sciences de la vie
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ESA, MEDES, France Biotech, 
ConnectbyCNES
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Description
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L'accélérateur industriel BSGN LifeScience, piloté par le BSGN de l'ESA, est géré par MEDES depuis 2021. Il s'inscrit dans la stratégie d'avenir de l'ESA, telle que l'Agenda 2025 et la feuille de route de la stratégie Terrae Novae 2030+. L'objectif du Business in Space Growth Network (BSGN) est de promouvoir l'accélération des activités commerciales en orbite terrestre basse.

L'objectif de l'accélérateur industriel en sciences de la vie du BSGN est de :

stimuler un écosystème spatial commercial en orbite basse,

soutenir des projets qui présentent des défis terrestres pouvant être résolus en utilisant des moyens spatiaux, 
soutenir les activités axées sur le marché,
 impliquer de nouveaux acteurs qui sont des néophytes dans le secteur spatial.


Pour ce faire, l'ESA a lancé 3 accélérateurs pour agir dans différents domaines :


MEDES pour les sciences de la vie et la biofabrication,

SCE pour l'agriculture et l'alimentation,

Catapult pour les matériaux et la fabrication avancés.


Tous les accélérateurs travaillent conjointement pour renforcer les capacités du programme.
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Les sciences de la vie et la bioproduction sur le marché spatial
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Dans le cadre de la mise en place de l'accélérateur BSGN "LifeScience Industry", l'une des premières tâches de MEDES a été de réaliser une évaluation du marché dans les domaines des sciences de la vie et de la bioproduction.
Les principales conclusions sont présentées dans la figure ci-contre.
Cette étude de marché a démontré que les secteurs des sciences de la vie et de la bioproduction disposent d'un énorme potentiel pour mener des recherches dans l'espace à des fins commerciales. Parallèlement, elle a  montré que la plupart des acteurs du secteur ne savaient pas comment mener un projet utilisant les moyens ou l'environnement spatial. Ils considèrent donc l'accélérateur comme une chance d'accéder à l'espace.
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Perspectives
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Aujourd'hui, l'accélérateur est encore en phase de développement. MEDES prévoit un mise en oeuvre des premiers projets en 2024.
A terme, l'Accélérateur devrait servir d'intermédiaire entre les porteurs de projets et les partenaires tels que l'ESA ou d'autres agences spatiales. Pour ce faire, l'accélérateur lancera un appel annuel et fournira des services d'accélération en fonction des besoins et des objectifs des projets et des partenaires.
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Pour aller plus loin
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Consultez les sites d'information suivants :
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Site du BSGN
Site BSGN Life Sciences Industry Accelerator

Vidéo ESA Euronews: How astronaut health studies help us Earthlings

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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2017 - ...
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En cours
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Gestion des contreparties financières 
pour les investigateurs cliniques
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MEDES, CHU Toulouse, CHU Nîmes
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Les contreparties financières sont des contreparties versées pour des études cliniques commerciales aux investigateurs de recherches, par les laboratoires /  entreprises pharmaceutiques.
Elles sont utilisées dans le but de développer la recherche et de manière suffisamment large pour permettre aux investigateurs de recherche clinique, dans le cadre de la réalisation de leurs projets de  recherche, d’acheter des équipements, des fournitures ou des prestations, payer des déplacements, participer à un congrès, séminaire, des formations…
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La gestion réglementaire des contreparties financières
Le gouvernement a décidé de mettre en place un contrat unique pour les recherches biomédicales à promotion industrielle dans les établissements publics de santé dans le but de réduire la durée de signature des conventions qui lient l’industriel promoteur de la recherche aux différentes parties prenantes hospitalières réalisant l’investigation.
Ce contrat est à la fois unique en ce qu’il associe le promoteur industriel, l’établissement de santé et l’investigateur pour un même lieu de recherche, mais également parce qu’il a vocation à être utilisé à l’identique par tous les établissements de santé souhaitant participer à la recherche.
Une circulaire ministérielle, parue en juin 2014 (circulaire DGOS/PF4/2014/195), a permis la mise en œuvre de la mesure dans les établissements publics de santé, à la fois par l’utilisation systématique d’un modèle de contrat, réduisant le nombre de clauses à négocier, et par l’application d’une modalité prédéfinie pour établir la liste et le montant des surcoûts générés par la recherche. En janvier 2016, l’article 155 de la loi de modernisation de notre système de santé a modifié les termes « contrat unique » et « incitations financières » respectivement par « convention unique » et « contreparties ».
Le GIE MEDES est éligible pour assurer la gestion des contreparties financières, en qualité de structure tierce, co-signataire à ce titre de la convention unique. L’assemblée des membres a approuvé cette nouvelle activité et l'a intégrée dans les statuts du GIE lors d'une assemblée exceptionnelle le 10 avril 2015.
 
Cette activité est actuellement menée par MEDES pour les CHUs de Toulouse et de Nîmes.
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L'application ASTRAM
 
MEDES a mis en place une application web dédiée pour permettre aux investigateurs d'engager les dépenses, d'assurer leur suivi et d'accéder à l'état de leur compte par Internet. Cette application est compatible avec les versions des navigateurs suivants (ou plus récents) :

IE 11
Mozilla Firefox
Google Chrome
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Pour plus d'informations
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Merci de prendre contact avec la responsable de ces activités au 05 34 31 96 00.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2009
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.3" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Prévention du diabète
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CNES, CHU Toulouse, Diamip, MEDES, 
ONSIL, IRIT, OVEA, Fleuret
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Un projet destiné à améliorer la prise en charge du diabète
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Au côté de 8 autres partenaires, MEDES s'est impliqué à partir de 2009 dans la réalisation du projet Diabsat, programme itinérant de dépistage des complications chroniques du diabète.
En utilisant notamment le satellite, DIABSAT a permis la mise en place de nouveaux moyens pour aider le malade au quotidien.
Ce projet est aujourd'hui géré par l'Association Diabète Occitanie. Il s’inscrit dans une démarche novatrice visant à aider à la prise en charge des patients diabétiques au plus près de leur lieu de vie et à les sensibiliser au suivi des complications chroniques.
Ainsi, un camion équipé de plusieurs appareils médicaux sillonne les départements de l'ex-région Midi-Pyrénées depuis 2010 et l’Occitanie dans son ensemble depuis 2017.
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Objectifs du projet
Le projet est parti du constat que le diabète est une maladie qui concerne de plus en plus de personnes en France et dans le monde. Les chiffres ne cessent d’augmenter et on parle de véritable épidémie. Sans une prise en charge adaptée, cette maladie peut entrainer de graves complications. Pourtant, des solutions permettent aux malades de mieux vivre avec la maladie : un dépistage précoce, un suivi médical et une modification du mode de vie (nutrition et activité physique).
Porté par des partenaires investis et un programme innovant, le projet DIABSAT a été sélectionné en mai 2009 par le Conseil régional de Midi-Pyrénées suite à un appel d’offre. Il se base alors sur une approche thérapeutique innovante et des technologies nouvelles pour la prise en charge des patients. Cela inclut :

La prévention, avec des logiciels éducatifs
Le dépistage des complications du diabète, avec une équipe mobile qui sillonne la région
Le suivi à domicile, avec un recueil d’informations à distance grâce à un téléphone portable.

MEDES a principalement travaillé sur le volet 3 du projet : le suivi à domicile.
 
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Pérennisation du projet
 
Le projet a été un franc succès et le camion développé dans le cadre du projet sillonne encore aujourd'hui les départements de la région Occitanie et les patients diabétiques peuvent bénéficier gratuitement d'examens médicaux selon leurs besoins et/ou à la demande du médecin traitant ou du diabétologue.

Depuis son démarrage en 2010, le programme DIABSAT a permis de recevoir 5 700 personnes diabétiques au cours de plus de 780 journées.

Concrètement, le réseau DIAMIP déploie le camion :


lors de campagnes départementales mises en œuvre par l’Association
lors de journées de dépistage ponctuelles « à la demande » pour la patientèle des structures qui sollicitent l’Association


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Vous pouvez retrouver le détail du programme, le calendrier des dépistages et les contacts clés sur le site DIAMIP
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Nos actualités
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/nos-projets/" global_colors_info="{}"]
Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2015
[/et_pb_blurb][et_pb_blurb title="Etat d'avancement :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Terminé
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Etude des effets des vols spatiaux sur le corps humain
Etude de l'immersion sèche comme modèle de simulation
[/et_pb_blurb][et_pb_blurb title="Partenaire :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
CNES
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MEDES a testé une nouvelle méthode de simulation de l’impesanteur : l’immersion sèche !
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MEDES a réalisé en 2015, pour le compte du CNES, une étude clinique dont le but était d’étudier les effets d’un modèle de simulation au sol des effets de l'impesanteur appelé « immersion sèche ».

Cette étude aura été la toute première utilisant le modèle d'immersion sèche en Europe !

Ce modèle, mis au point et utilisé par les scientifiques russes, n’avait pas été véritablement étudié jusqu’à présent en Europe où un autre modèle, l’alitement prolongé ou « bed rest » est plus utilisé. MEDES a en effet mené de très nombreuses études de ce type, en testant, selon les études, des méthodes de prévention comme l’exercice, une nutrition adaptée,  une solution médicamenteuse, la gravité artificielle, des exercices vibratoires…
 
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Ce nouveau modèle « d’immersion sèche » a paru intéressant car il induirait certains effets physiologiques que le modèle de bed rest ne permet pas de reproduire fidèlement et serait donc complémentaire de ce dernier.
L’atout le plus important de l’immersion sèche est l’absence de support : l’appui est reparti de manière égale sur toute la surface corporelle. L’organisme humain l'interprète comme une absence complète d’appui, situation comparable à celle de la microgravité réelle. Les autres facteurs agissant en même temps sur le corps humain en immersion sont l’inactivité physique importante, du fait d’une diminution des mouvements et d’une absence de la charge corporelle et de la pression de l’eau. Le modèle d’immersion sèche permet ainsi de reproduire très rapidement les effets de l’impesanteur sur les systèmes sensori-moteur et cardiovasculaire.
Le CNES a donc décidé de mener cette première étude, considérée comme pilote, pour évaluer les effets de ce modèle et juger de son intérêt.
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Le déroulement de l'étude
Concrètement, le volontaire a été installé dans une sorte de baignoire adaptée (2.10m x 1.10m x 0.85m) spécialement conçue pour cet usage et remplie d’eau. Une toile élastique spéciale, parfaitement imperméable est fixée sur le bord extérieur autour de la baignoire et permet au volontaire d’être isolé de l’eau.
Cette étude a été menée sur le mois de février 2015, dans les locaux de la Clinique Spatiale. 12 volontaires hommes sains, âgés de 20 à 45 ans, ont pris part à l’étude.
Ils sont restés chacun « immergé » 3 jours. À cela se sont ajoutés 3 jours précédant l’étude pour effectuer les mesures de base et 2 jours post-immersion afin de réaliser les mesures comparatives et avoir le temps nécessaire pour récupérer.
 
De nombreuses mesures et évaluations ont été effectuées au cours de l’étude. On peut les classer en 2 catégories :

Les tests standards (appelés BCD), réalisés dans toutes les études de ce type,
Les tests prévus dans les protocoles scientifiques.
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Les protocoles menés pendant l'étude
5 équipes scientifiques ont participé à l’étude et ont proposé des protocoles spécifiques :

Protocole 1 : « Vivre en microgravité : comprendre et prévenir la perte de masse et de force musculaire »
Directeur de la recherche : Pr. Angèle CHOPARD, Université de Montpellier I, Dynamique musculaire et métabolisme (DMEM), Montpellier.


Protocole 2 : « Effets de l’immersion sèche sur les réponses intégrées cardiaque et vasculaire au stress orthostatique, le transfert liquidien et l’adaptation du système nerveux central et périphérique»
Directeur de la recherche : Dr Custaud, Laboratoire de Biologie Neurovasculaire, Faculté de Médecine, Angers, France.


Protocole 3 : « Impact des altérations vestibulaires sensorimotrices pendant l’immersion sèche sur les régulations cardiovasculaires »
Directeur de la recherche : Pr Pierre DENISE, Faculté de Médecine, Université de Caen Basse-Normandie


Protocole 4 : « Effets de 3 jours d’immersion sèche sur la colonne vertébrale »
Directeur de la recherche : Pr C. Gharib, Université Claude Bernard Lyon 1, Faculté de Médecine Lyon Est, Lyon.


Protocole 5 : « Effet de l’immersion sur les marqueurs du remodelage osseux, relation avec la sensibilité à l’insuline »
Directeur de la recherche : Mme Laurence Vico, Inserm U1059 et Laboratoire Biologie intégrative du Tissu Osseux (LBTO), Faculté de Médecine, Saint-Etienne
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Cette étude, la première du genre, aura marqué l'utilisation de ce nouveau modèle de simulation de l'impesanteur, pour le CNES, puis pour l'ESA dont de récentes études ont été réalisées.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(16427) "[et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" background_enable_color="off" background_image="https://www.medes.fr/wp-content/uploads/2022/06/AdobeStock_279577524-compressed-scaled.jpg" custom_padding="40px||40px||true|false" custom_padding_tablet="30px||30px||true|false" custom_padding_phone="30px||30px||false|false" locked="off" global_colors_info="{}" custom_css_after_last_edited="off|desktop"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="|auto|40px|auto|false|false" custom_margin_tablet="||30px||false|false" custom_margin_phone="||30px||false|false" custom_margin_last_edited="on|phone" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.17.4" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_orientation="center" custom_margin="||14px||false|false" custom_padding="||0px|||" header_text_align_tablet="" header_text_align_phone="left" header_text_align_last_edited="on|phone" global_colors_info="{}"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[/et_pb_text][et_pb_text _builder_version="4.19.1" _module_preset="default" global_colors_info="{}"]
Evaluation d’un tonomètre à ultrasons sur la mesure de paramètres artériels au niveau carotidien et fémoral.
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2012
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Evaluation d'un tonomètre à ultrasons
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ESA, MEDES, Verhaert
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Contexte
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Lors de leur retour sur Terre après des vols spatiaux de diverses durées, les astronautes rencontrent fréquemment des problèmes de type malaise lors qu’ils changent de position, par exemple lorsqu’ils passent de la position assise à debout, ou couchée à debout ou encore lorsqu’ils maintiennent une position debout de façon prolongée. On parle d’intolérance orthostatique. Elle s’explique par une perte de la capacité du système cardiovasculaire à maintenir un apport d’oxygène suffisant au niveau du cerveau. Il s’ensuit donc un malaise pouvant aller jusqu’à une perte de connaissance.
 
Objectifs de l'étude
 
Afin de mieux évaluer ces phénomènes au niveau artériel dans des conditions très particulières (microgravité, études cliniques de simulation, vols paraboliques, …) l’Agence Spatiale Européenne a décidé de développer divers appareils destinés à mieux comprendre et analyse les mécanismes physiologiques impliqués dans ces malaises. Dans ce cadre, et en collaboration avec des experts scientifiques de l’université de Ghent, la société belge Verhaert développe un appareil alliant les principes de la tonométrie et du doppler à ultrasons destiné à mesurer différents paramètres caractéristiques de l’état physiologique des artères. Cet appareil devrait permettre de mesurer notamment les pressions artérielles en divers sites, le diamètre artériel, la durée d’éjection, la vitesse de propagation de l’onde sanguine, et ce, de manière totalement non-invasive.
 
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Appareil testé : CPMM ou tonomètre et une sonde à ultrasons. Cet appareil permet l’enregistrement de variations fines de la pression en regard du capteur. Il recueille les mouvements liés aux pulsations cardiaques et au mouvement du sang dans les vaisseaux.
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Déroulement de l'étude
 
14 sujets hommes et femmes âgés de 20 à 40 ans ont participé à cette étude.
Le sujet a été allongé sur une sorte de lit pouvant se relever mécaniquement. Cet appareil est appelé une table de Tilt. Cette table de Tilt est équipée d’un système appelé LBNP (pour Low Body Negative Pressure) qui consiste en une sorte de grosse boite dans laquelle le sujet entrera ses jambes et son bassin. Ce système permet d’appliquer une pression négative (comme pour faire le vide) sur la partie basse de votre corps. Une jupe en néoprène, semblable à celle installée sur les kayaks, permettra de garantir une fermeture hermétique de la boite. Le sujet est alors équipé de plusieurs matériels : , sondes à ultrasons, capteurs tonométriques, Finapres, le Dynamap, table de tilt.
Des mesures en LBNP et lors du tilt test sont alors enregistrées.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2010
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Terminé
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Etude des effets des vols spatiaux sur le corps humain
Evaluation de la gravité artificielle comme contre-mesure
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ESA, CNES, MEDES
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MEDES a réalisé en 2009-2010 une étude d'alitement ayant pour objectif d'évaluer la gravité artificielle, créée par une centrifugeuse à bras courts, pour prévenir les effets de l'impesanteur, simulée par alitement anti-orthostatique.
L'évaluation a été menée par deux protocoles de centrifugation utilisés comme contremesure pour prévenir le déconditionnement induit par 5 jours d’alitement anti-orthostatique chez des hommes sains.
Il s'agit d'une étude ESA-CNES.
Cette étude a été rendue possible par l'installation d'une centrifugeuse à bras courts dans les locaux de la Clinique Spatiale, installation réalisée en 2007.
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Contexte
Un des objectifs des programmes spatiaux en cours est de préparer les futures missions habitées interplanétaires, qui pourront avoir des durées allant jusqu’à 3 ans (comme par exemple vers Mars). L’exposition à l'environnement spatial et en particulier à l'impesanteur pendant de telles durées entraîne des modifications physiologiques intéressant notamment les systèmes cardio-vasculaire, musculaire, osseux et neuro-sensoriel. Des moyens préventifs, aussi appelés « contre-mesures », sont utilisés pour lutter contre ces effets délétères de l'exposition à l'environnement spatial et préparer le retour au sol des astronautes. Les contre-mesures actuelles sont essentiellement fondées sur l’exercice physique (tapis roulant, vélo-ergomètre) ou sur le Lower Body Negative Pressure (ou LBNP, caisson dans lequel est appliquée une pression négative sur la partie inférieure du corps). Elles avaient d'ailleurs été testées lors des précédentes études d'alitement réalisées à la Clinique Spatiale.
Ces contre-mesures sont aujourd’hui utilisées par les équipages permanents de la Station Spatiale Internationale (ISS) qui restent à bord jusqu’à 180 jours. Néanmoins, elles n’ont qu’une efficacité partielle, probablement parce qu’elles n’intéressent qu’un système physiologique à la fois (muscles et peut-être l’os pour l’exercice, système cardio-vasculaire pour le LBNP etc.).
La gravité artificielle représente dès lors une approche plus globale au problème des contre-mesures puisqu’elle permet de simuler simplement notre environnement gravitationnel terrestre, ayant ainsi des répercussions sur l’ensemble de nos systèmes physiologiques.
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Déroulement de l'étude
12 volontaires de sexe masculin, répartis en 3 groupes, ont participé à cette étude. Elle s'est déroulée à la Clinique Spatiale (MEDES) en trois périodes d’hospitalisation de 15 jours espacées de 4 à 5 semaines.
Chaque période d’hospitalisation de 15 jours comprenait :

Une période ambulatoire contrôle de 5 jours ,
Une période d'alitement anti-orthostatique (-6°) d'une durée de 5 jours,
Une période ambulatoire de récupération de 5 jours

Les 12 volontaires ont été répartis en 3 groupes comme suit :

Groupe « Centrifugation continue » (4 volontaires),
Groupe « Centrifugation intermittente » (4 volontaires),
Groupe « Contrôle » (4 volontaires).

Chacun des volontaires a changé de groupe à chaque période d'hospitalisation et a donc été son propre sujet de contrôle.
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Protocoles de contremesures


Répartition des groupes de volontaires : 
 

Groupe Centrifugation continue : Chaque jour d’alitement , les volontaires ont été soumis à une accélération de 1g au niveau du centre de masse (niveau du bassin) pendant 30 minutes en position allongée.



Groupe Centrifugation intermittente : Chaque jour d’alitement, les volontaires ont été soumis à une accélération de 1g au niveau du centre de masse pendant 5 minutes en position allongée. La centrifugeuse est alors arrêtée en quelques secondes et une nouvelle phase de 5 minutes identique à la précédente débute. 6 phases de 5 minutes sont ainsi effectuées.

 

Groupe Contrôle : ce groupe sert de témoin à l’expérimentation. Les sujets de ce groupe n'ont pas fait pas de séance de centrifugation. Ce groupe permet par comparaison d’évaluer l’effet des 2 types de “ contre-mesures ” sur chacun des volontaires.
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Pour aller plus loin
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La centrifugeuse, équipement clé de la Clinique Spatiale
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2017
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude des effets des vols spatiaux sur le corps humain
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ESA
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Etude de simulation de l'impesanteur réalisée en 2017
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Pour le compte des agences spatiales françaises (CNES) et européennes (ESA), MEDES a réalisé une nouvelle étude au sol de simulation de l'impesanteur. 20 volontaires ont pris part à cette étude de longue durée qui s'est déroulée en 2 phases : une première campagne avec 10 volontaires de janvier à avril 2017 et une deuxième campagne de septembre à décembre 2017
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Cette étude d'alitement, baptisée Cocktail, était une étude d'alitement anti-orthostatique (position du volontaire la tête plus basse que les pieds) de longue durée 2 mois d'alitement.
Ses objectifs étaient d'évaluer :


les mécanismes d’adaptation du corps humain à 60 jours d’impesanteur simulée par alitement


les effets d’une contre-mesure nutritionnelle (la contre-mesure COCKTAIL) à l’aide d’une batterie de tests standardisés, pour contrer les effets néfastes de l’impesanteur sur le corps humain.

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Méthode de prévention
Cette contre-mesure (méthode de prévention) était un complément alimentaire antioxydant et anti-inflammatoire (mélange d’extraits naturels polyphénoliques de plantes alimentaires) que les volontaires ont pris plusieurs fois par jour sous forme de gélules. La moitié des volontaires a pris le complément alimentaire et l'autre moitié a servi de groupe contrôle et n'a donc pas pris le cocktail de gélules.
16 équipes scientifiques européennes ont participé à l'expérience et se sont intéressées aux modifications induites par l'alitement et les effets de la méthode de prévention testée sur les domaines suivants :  le métabolisme, le système cardiovasculaire, le muscle, l'os, l'immunologie, le système neurosensoriel ou encore le sommeil.
L'étude a duré 3 mois (dont 2 mois d'alitement) et s'est déroulée en 3 étapes :

15 jours de mesures en amont de l’alitement sur chacun des volontaires
2 mois d’alitement anti-orthostatique à -6° (la tête plus basse que les pieds)

15 jours de récupération lors desquels de nouvelles mesures sont effectuées post-alitement et permettent d’étudier les effets de l’alitement et de la contre-mesure sur l’organisme par comparaison avec les mesures faites avant l’alitement
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Nos volontaires
Les volontaires sélectionnés l'ont été après appel à candidature et avec des critères de sélection bien précis :

Homme de 20-45 ans
En parfaite santé
Non-fumeur
Indice de Masse Corporelle entre 22 et 27
Pratiquer une activité sportive régulière, ne pas avoir d'allergie ni restriction alimentaire.

La sélection s’est faite en plusieurs étapes : dossier d'inscription (vérification des critères de sélection et de la compréhension de l'étude), sélection médicale puis sélection psychologique.
Si ces recherches sont très utiles pour faire avancer la recherche spatiale, elles trouvent également un intérêt pour la médecine sur Terre. En effet, ces longues périodes d’immobilisation sans activité physique chez des sujets sains permettent aux scientifiques une meilleure compréhension de certaines maladies telles que l’obésité, le diabète ou encore l’ostéoporose.
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Pourquoi un alitement à -6° ?
Après plusieurs décennies de pratique, il a été déterminé que cette inclinaison de -6° (pieds légèrement au-dessus de la tête) correspondait à ce que vit le corps d’un astronaute en situation d’impesanteur. Cette position induit en effet une migration des liquides de l’organisme vers la partie supérieure du corps, comme on l’observe dans l’espace. Cela permet de simuler l’impesanteur tout en gardant les pieds (presque) sur Terre !
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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Etude d'alitement BRACE
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2023
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En cours
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Mieux comprendre les effets de la micropesanteur sur l'organisme
Tester la centrifugation et l'exercice comme contre-mesures
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ESA, CNES, MEDES
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MEDES réalise une étude de simulation de la microgravité au sol pour préparer les futurs vols spatiaux habités de longue durée.
Alors que l'ESA a récemment recruté une nouvelle promotion d'astronautes, la recherche au sol continue pour préparer les futurs vols spatiaux de longues durées.
A la demande des agences spatiales française (CNES) et européenne (ESA), MEDES réalise dans les locaux de sa Clinique Spatiale une étude de simulation de la microgravité utilisant le modèle d’alitement Cette étude, nommée BRACE (Bed Rest with Artificial gravity and Cycling Exercise) prévoir d'inclure 24 volontaires hommes en bonne santé au total. Elle se déroule en 2 phases de 12 volontaires chacune. L’étude dure 88 jours dont 60 jours alités.
L’objectif est de mieux comprendre les effets de la microgravité sur le corps humain et de tester l’efficacité de 2 contremesures comme méthode de prévention :

Un protocole d’exercice sur véloergomètre associé à un protocole de centrifugation qui se déroulera sur la centrifugeuse humaine à bras courts. L’exercice sur vélo ergomètre se déroulera selon un protocole similaire à celui utilisé dans la Station Spatiale Internationale (ISS).
Un protocole d’exercice sur véloergomètre réalisé seul, selon un protocole identique à celui réalisé sur la centrifugeuse.
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Les tests et examens médicaux et scientifiques
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14 équipes scientifiques européennes sont impliquées dans l’étude et proposent des expériences sélectionnées par les comités d’évaluation de l’ESA dans les domaines neurologique, musculaire et osseux, cardiovasculaire, métabolique. De nombreux examens standardisés, tels qu’urinaires, sanguins, ophtalmologiques, psychologiques… viennent compléter ces expériences.
Les différents examens permettront une meilleure compréhension des effets de l’alitement prolongé sur les différents systèmes physiologiques, sur leurs interrelations ainsi que sur les effets des deux contremesures. Une batterie de mesures standards explorant les différents systèmes physiologiques est également réalisée en plus des mesures proposées par les scientifiques. Ces mesures sont mises en œuvre depuis plus de dix ans sur toutes les études d’alitement réalisées en Europe. Elles permettent d’évaluer de la même façon les différentes contremesures testées et de comparer leur efficacité entre elles.
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Les volontaires de l'étude
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Les principaux critères de sélection et d’inclusion des volontaires ont été les suivants :

Hommes en bonne santé
Âgés de 20 à 45 ans
Sans surpoids ou maigreur excessive, avec un IMC compris entre 20 et 27
Taille comprise entre 158 cm et 190 cm
Bon état de santé confirmé par un examen clinique complet
Bon état de santé mentale, vérifié par une batterie de tests et entretiens psychologiques faits et interprétés par une spécialiste en psychologie des milieux extrêmes
En bonne forme physique
Non-fumeurs
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La sélection s’est faite en plusieurs étapes : deux entretiens téléphoniques (vérification des critères de sélection et de la compréhension de l'étude), sélection médicale (à la clinique) puis sélection psychologique et test avec centrifugeuse (à la clinique). 
A l’issue de la sélection, 12 candidats ont été retenus.
Les 12 volontaires ont été répartis en 3 groupes :

4 volontaires recevant le protocole de contre-mesures de gravité artificielle couplée à un exercice sur vélo ergomètre
4 volontaires recevant le protocole de contre-mesures avec exercice sur véloergomètre allongé
4 volontaires contrôles ne recevant aucun protocole de contre-mesures 


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Le déroulement de l'étude
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Les volontaires sont présents 88 jours à la Clinique Spatiale dont 60 jours alités. L’étude se déroule ainsi :

14 jours précèdent la période d’alitement pour les mesures de base avec une arrivée des volontaires à J-15
60 jours d’alitement à - 6° (tête plus basse que les pieds)
14 jours qui suivent la période d’alitement afin de permettre les mesures post alitement et la récupération

Par ailleurs, il est prévu 3 visites de suivi d’un jour chacune : à 30 jours puis 1 an puis 2 ans après le dernier jour d’alitement.
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La 1ère phase de l'étude a eu lieu au printemps 2023. La 2ème campagne, équivalente à la première, a démarré début févriert 2024 et prendra fin début mai. Une cohorte totale de 24 volontaires aura ainsi été composée.
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Pour aller plus loin
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Consultez les articles sur l'étude : 
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Reportage France2, 19 mai 2023 "Voyage sur Mars : préparer son corps pour ce long périple"
Article ESA: "Around the bed in sixty days"

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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2012-2013
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Terminé
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Etude des effets des vols spatiaux sur le corps humain
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ESA
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L’étude d’alitement MNX (« Medium duration Nutrition and vibration eXercise » study) entre dans le cadre d’un programme de recherche mené sous la direction des agences spatiales françaises et européennes.
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Elle a pour but principal d’étudier l’efficacité de deux moyens de prévention (encore appelé contre-mesures) contre les effets de l’impesanteur à laquelle sont soumis les astronautes :

un exercice des membres inférieurs (type « squats ») en résistance réalisée sur plateforme vibrante. Cet exercice étant effectué deux fois par semaine,
le même programme d’exercice physique associé à une supplémentation en protéines et en bicarbonate de potassium dans l’alimentation quotidienne.

12 volontaires ont été recrutés pour cette étude. Ils ont vécu 3 périodes d’hospitalisation de 35 jours chacune (dont 21 jours alités à chaque fois). Chaque période était séparée de la suivante par une durée de 4 mois et la durée totale de l’étude est donc de 1 an.
9 équipes scientifiques ont participé à l’étude.
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L'étude en quelques chiffres
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Modalités de déroulement de l’étude
Les 12 volontaires de l’étude ont été répartis en 3 groupes.
Les 3 groupes sont les suivants :

Groupe « Exercice et vibration » (4 volontaires),
Groupe « Exercice et vibration plus nutrition » (4 volontaires),
Groupe « Contrôle » (4 volontaires).

Cette étude est dite croisée, c’est-à-dire que chacun des 12 volontaires a été son propre témoin et a changé de groupe à chaque période. L’ordre de passage dans les 3 groupes a été déterminé par tirage au sort.
Groupe exercice et vibration : pendant la période d’alitement, à raison de 2 fois par semaine, les volontaires de ce groupe ont effectué un entraînement physique (exercices type « squats », c'est-à-dire un exercice de poussée avec les jambes) sur une plateforme vibrante en position couchée sur un appareil spécialement conçu à cette fin.
Groupe exercice et vibration plus nutrition : pendant la période d’alitement, les volontaires de ce groupe ont fait le même entraînement physique que le groupe précédent et ont reçu une alimentation quotidienne légèrement modifiée. En effet, la quantité de protéines dans l’alimentation quotidienne a été augmentée par un apport supplémentaire en protéines de petit-lait et du bicarbonate de potassium. Cette supplémentation a été administrée aux principaux repas et avec les collations (soit 6 fois/jour).
 Groupe Contrôle : ce groupe a servi de témoin à l’expérimentation. Les sujets de ce groupe n’ont fait pas de séance d’exercice sur plateforme vibrante et ont suivi une alimentation standard contrôlée. Ce groupe aura permis, par comparaison, d’évaluer l’effet des 2 types de contremesures sur chacun des volontaires.
Pour chaque période d’hospitalisation de 35 jours, 3 phases sont à distinguer :

Une période ambulatoire contrôle de 7 jours avant l’alitement,
Une période d'alitement anti-orthostatique (-6°) d'une durée de 21 jours,
Une période ambulatoire de récupération de 7 jours après l’alitement.

À la fin de chaque période d’hospitalisation, les volontaires sont revenus pour des visites de suivi 14 jours et 28 jours après chaque campagne d’alitement.
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Les protocoles scientifiques
9 équipes scientifiques ont étudié les mécanismes d’adaptation de l’organisme à 21 jours de microgravité simulée ainsi que l’effet des 2 protocoles de contremesure sur les systèmes physiologiques suivants :

Les systèmes métaboliques (M. Heer et le Groupe d’Expert en Nutrition de l’ESA),
Le système cardio-vasculaire et ses mécanismes de contrôle (M.A. Custaud, P. Vaida, E. Caiani),
Le système ostéo-articulaire et les muscles (D. Belavy, G.P. Brueggemann, S. Boyd),
Le système sanguin et principalement les mécanismes de la coagulation sanguine (M. Hinghofer-Szalkay).
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Les principaux responsables scientifiques qui ont participé à cette étude sont les suivants :
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La nutrition pendant l’étude
La nourriture, et tout ce qu’elle entoure (santé, convivialité…) est essentielle pour les astronautes en mission de longue durée.
L’Agence Spatiale Européenne (ESA) a ainsi défini une stratégie à long terme pour standardiser les conditions des études d’alitement notamment pour la nutrition (Groupe d’experts en Nutrition de l’Agence Spatiale Européenne : Mme M. Heer, M. S. Blanc et Dr G. Biolo).
Au cours de ces expériences les apports nutritionnels ont ainsi été parfaitement contrôlés et maîtrisés.
Pour cette étude MNX, MEDES a pu répondre aux exigences de l’ESA en matière de Nutrition grâce à l’étroite collaboration qu’il entretient depuis toujours avec le service Hôtelier du CHU de Toulouse (Mr Christian Lalande, Ingénieur en Chef chargé de l’hôtellerie) et de la société Davigel qui produit des plats cuisinés servis aux patients et personnels du CHU de Toulouse.
Les services de Mr Lalande et de Mr Yout, Directeur du CFEC (Centre de Formation et d’Expertises culinaires) avaient accepté le défi de fabriquer pour MEDES les plats principaux et les collations pour les 3 campagnes. Le service hôtelier du CHU a fourni les entrées et les desserts.
La technologie « surgelé » ainsi que la sélection des matières premières par la société Davigel ont permis de produire en une seule fois l’ensemble des plats ce qui a permis la reproductibilité de la qualité nutritionnelle sur les 3 campagnes.
Les menus devaient contenir des taux de macronutriments (protéines, lipides, glucides) et micronutriments (vitamines, minéraux…) standardisés. Les valeurs nutritionnelles de chaque plat ont donc été évaluées grâce aux données fournies par Davigel et complétées au besoin par des analyses en laboratoire. Puis ces valeurs ont été saisies dans un logiciel de nutrition permettant de calculer les apports quotidiens. Les rations alimentaires ont ensuite été adaptées en fonction du métabolisme basal de chaque volontaire, en fonction de leur poids, et de l’activité physique (période debout ou couché à -6°, exercice etc.).
Ce travail minutieux aura été essentiel pour cette étude où le suivi nutritionnel des volontaires aura tenu une place prépondérante.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2005
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectifs : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude des effets des vols spatiaux sur le corps humain
Contre-mesure nutritionnelle et exercice
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CNES, ESA, NASA, CSA
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L'étude WISE (Women International Space Simulation for Exploration), menée en 2005-2006, est une étude d'alitement réalisée sur 24 volontaires femmes qui sont restées 100 jours à la Clinique Spatiale de Toulouse dont 60 jours allongées pour simuler les effets de l'impesanteur.

L'étude s'est déroulée en 2 sessions : d'avril à juin 2005 pour les 12 premières volontaires et de septembre à décembre pour les 12 autres.
Cette étude d'alitement a été organisée par MEDES pour les Agences Spatiales Française, Européenne, Américaine et Canadienne (CNES, ESA, NASA, ASC).
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Une étude essentielle pour faire avancer la recherche
 
Les vols spatiaux n'étant pas chose courante, il est primordial de faire des études au sol pour préparer les vols habités de longue durée.
24 volontaires femmes ont donc ainsi participé durant 100 jours à cette étude en restant notamment restées 60 jours allongées la tête légèrement inclinée vers le bas (-6°) pour simuler les effets physiologiques d’un séjour prolongé en impensateur.
MEDES réalise régulièrement des expériences d'alitement mais celle-ci fut la première expérience longue durée sur des volontaires femmes.
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L’expérience a eu pour but d’étudier dans quelle mesure l’alimentation et l’exercice physique peuvent pallier les effets néfastes de l’absence prolongée de gravité, que ces conditions d’alitement permettent de simuler.
Les volontaires ayant participé à l'étude sont originaires de France, de Grande-Bretagne, d’Allemagne, de Finlande, des Pays-Bas, mais aussi de Pologne et de République tchèque, signe de l’intérêt considérable que l’étude WISE suscite également dans les nouveaux Etats membres de l’Union européenne.
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Objectifs de l'étude

Les objectifs de l'étude ont été d’évaluer les conséquences d’un long vol simulé et de tester l’efficacité des contre-mesures utilisées.
Des équipes scientifiques reconnues au plan international ont réalisé des protocoles dans les domaines suivants :

Capacité physique,
Fonction cardiaque et circulation sanguine,
Mesures sanguines,
Structure et fonction musculaires,
Structure et fonction osseuses,
Besoins énergétiques et nutritionnels,
Système immunitaire,
Régulation hormonale et cycle de reproduction,
Réflexes et équilibre,
Humeur et bien-être.
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Déroulement de l'étude
 
L'étude WISE s'est déroulée en 2 campagnes regroupant chacune 12 volontaires.
Les volontaires ont été reparties au hasard en trois groupes :

Un groupe a servi de groupe contrôle et n'a reçu aucune contre-mesure.
Un groupe a réalisé une combinaison d’exercices physiques tout en restant alité.
Le troisième groupe a reçu un complément nutritionnel.

Les résultats ainsi obtenus ont pour but d'être comparés à ceux des astronautes au cours des vols spatiaux.
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L'étude a duré 101 jours dont 60 jours en position couchée, répartis comme suit :

 La première phase de l'étude a consisté pour les volontaires à subir une série de tests destinés à recueillir les données physiologiques de base qui serviront de référence pendant toute la durée de l’étude.
A l’issue de cette phase d’observation préliminaire de 20 jours a eu lieu la phase d’alitement proprement dite. Pendant cette phase les volontaires ont participé à toute une série d'examens et de tests en rapport avec les divers protocoles de l'étude. Durant cette phase d'alitement, les volontaires ont dû rester dans la position tête en bas (6° en dessous de l’horizontale) sans se lever, ni pour les repas et ni pour la toilette. Seuls, les mouvements qui maintiennent l’axe du corps dans cette position ont été autorisés. Outre ces tests, les journées des volontaires ont également été ponctuées de temps de loisirs. Les volontaires ont eu accès à la télévision, Internet ou le téléphone pour dialoguer avec leurs proches. Elles ont également eu l’opportunité de prendre des cours de langue, de profiter de séances d’esthéticienne… et ont même eu la visite de Mme Claudie Haigneré, astronaute et ancienne Ministre déléguée aux affaires européennes et de M. Jean-François Clervoy et M. Pédro Duque, astronautes.
Pendant les 20 jours suivant l’alitement, les volontaires ont subi des tests identiques à la première phase dont les résultats ont pour but d'être comparés aux données de référence.
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Pour aller plus loin
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Elles ont relevé le défi de l'impesanteur - Article ESA
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(24828) "[et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" background_enable_color="off" background_image="https://www.medes.fr/wp-content/uploads/2022/06/AdobeStock_279577524-compressed-scaled.jpg" custom_padding="40px||40px||true|false" custom_padding_tablet="30px||30px||true|false" custom_padding_phone="30px||30px||false|false" locked="off" global_colors_info="{}" custom_css_after_last_edited="off|desktop"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="|auto|40px|auto|false|false" custom_margin_tablet="||30px||false|false" custom_margin_phone="||30px||false|false" custom_margin_last_edited="on|phone" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.17.4" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.19.1" _dynamic_attributes="content" _module_preset="default" text_orientation="center" custom_margin="||14px||false|false" custom_padding="||0px|||" header_text_align_tablet="" header_text_align_phone="left" header_text_align_last_edited="on|phone" global_colors_info="{}"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[/et_pb_text][et_pb_text admin_label="MEDES a mené pour l'ESA" _builder_version="4.19.1" text_font_size="1px" background_size="initial" background_position="top_left" background_repeat="repeat" locked="off" global_colors_info="{}"]
Etude de simulation de l'impesanteur utilisant le modèle original d'immersion sèche
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2019
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Terminé
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Étude des effets des vols spatiaux sur le corps humain
Contre-mesure testée : brassards de cuisse
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CNES
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Au 1er semestre 2019, 20 volontaires ont participé à une nouvelle étude de simulation de l'impesanteur utilisant un modèle original, l'immersion sèche.
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Ce modèle permet de simuler au sol les effets de l'impesanteur sur le corps humain et de tester une nouvelle méthode de prévention destinée à minimiser les effets négatifs de l'impesanteur sur le corps humain.
Cette étude, dont le CNES est le promoteur, a été réalisée dans les locaux de la Clinique Spatiale de MEDES sur le CHU de Rangueil, à Toulouse.
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Qu'est-ce que le modèle d'immersion sèche ?
Le volontaire qui participe à l’étude est installé dans une sorte de grande baignoire remplie d’eau tiède dont il est cependant isolé par une toile imperméable, accrochée sur les rebords de la baignoire. Il se trouve donc comme « entre deux eaux » et « flotte » ainsi en l’absence de support. Cette situation, interprétée par l’organisme comme une absence complète d’appui, est très comparable à celle de la microgravité.
Ce modèle permet notamment de reproduire très rapidement les effets de l’impesanteur sur les systèmes sensori-moteur et cardiovasculaire.
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5 jours d'immersion au service de la recherche spatiale

Une première étude avait été réalisée en 2015, puis une seconde en 2016-2017. Les volontaires étaient alors "immergés 3 jours". Pour cette étude, les 20 volontaires ont été immergés 5 jours. Les modifications physiologiques qui en découlent ont alors été observées, enregistrées et analysées par près de 10 équipes scientifiques précédemment sélectionnées par le CNES.
En particulier, cette nouvelle étude avait pour objectif de permettre d’approfondir la connaissance des mécanismes physiologiques mis en jeu et notamment d’étudier la redistribution des fluides corporels entraînée par l’immersion et leurs répercussions au niveau cérébral et ophtalmique.
Les volontaires sont restés 12 jours dans les locaux de la clinique pour cette étude, répartis ainsi :

4 jours pré-immersion pour effectuer les mesures de base,
5 jours d’immersion sèche
3 jours post-immersion afin de permettre les mesures post immersion et la récupération

Les 10 équipes scientifiques ont étudié les principaux effets physiologiques de 5 jours d’immersion sèche et de l’impact de l’utilisation des brassards de cuisse sur les systèmes suivants :

Le suivi ophtalmologique
Le système musculaire
Le système osseux
Les régulations cardiovasculaires
Le métabolisme et la flore intestinale
La cognition
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Une nouvelle méthode de prévention testée

La méthode de prévention testée, appelée contre-mesure, a été l'utilisation de brassards de cuisse. 
Ces brassards visent à réduire l’afflux des fluides vers la partie haute du corps que l’on observe en microgravité et devraient ainsi permettre de reproduire l’effet de la gravité sur le plan vasculaire. Ainsi certains effets négatifs de l'impesanteur sur l’organisme pourraient s'en trouver réduits et ce notamment au niveau cardiovasculaire et oculaire.
Cette contre-mesure, si elle s’avère efficace, pourrait aisément être utilisée par les spationautes d’autant qu’elle présente l’énorme avantage d’être particulièrement simple et facile à mettre en place.
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Pour aller plus loin
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MEDES, une clinique spatiale en France
Faire avancer le spatial en gardant les pieds sur Terre
L'immersion sèche, une autre méthode de simulation de l'impesanteur
Des brassards destinés au voyage dans l'espace testés en baignoire - Reportage France 3

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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(384) "Au 1er semestre 2019, 20 volontaires ont participé à une nouvelle étude de simulation de l’impesanteur utilisant un modèle original, l’immersion sèche.

Ce modèle permet de simuler au sol les effets de l’impesanteur sur le corps humain et de tester une nouvelle méthode de prévention destinée à minimiser les effets négatifs de l’impesanteur sur le corps humain. "
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2016
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Terminé
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Etude d'immersion sèche
Etude d'une contremesure physique (dispositf Wecare)
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ESA, CNES, Quinetic Space
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MEDES a mené, pour le compte de l'ESA,  une étude destinée à tester une nouvelle contre-mesure (méthode de prévention) destinée à garantir la santé des astronautes : le dispositif WECARE. Ce dispositif a été testé dans le cadre d'une étude simulation de l'impesanteur, utilisant le modèle d'immersion sèche, alors récemment installé dans les locaux de la clinique spatiale (1ère étude réalisée en 2015).
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Ce dispositif a été conçu par Qinetic Space et MEDES dans le cadre d’un contrat ESA.
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Pour cette étude, le modèle de simulation de l'impesanteur utilisé est l’immersion sèche. Le volontaire est « immergé » 3 jours dans une sorte de baignoire et est isolé de l’eau par une bâche.
 
Cette position simule les effets que peut ressentir l’astronaute lors d’un vol spatial et reproduit beaucoup des effets négatifs imposés par l’impesanteur sur l’organisme.
 
Le dispositif WECARE est une contre-mesure (méthode de prévention) destinée à prévenir et limiter ces effets négatifs. Il associe un exercice physique sur un « horizontal press leg » avec des vibrations du corps entier et un entraînement proprioceptif de la cheville.
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Objectif de l’étude
Conçu pour l’ESA avec le soutien du CNES, ce dispositif a pour objectif de lutter contre la déminéralisation osseuse et la fonte musculaire des astronautes pendant le vol spatial et d’entretenir sa proprioception.
Le dispositif est conçu comme un ensemble de 2 pédales actives servant de plateformes d’appui à la voûte plantaire des 2 pieds du sujet.
Il permet d’appliquer des contraintes mécaniques de deux types :

des vibrations visant à lutter contre la déminéralisation osseuse,
des mouvements de rotation au niveau des voûtes plantaires alors que le sujet effectue des exercices de flexion-extension des genoux. Cette contrainte vise à entretenir la proprioception du sujet et maintenir ses capacités à tenir en équilibre après la simulation.

Le volontaire utilise ce dispositif 45 min par jour en position allongée. 6 volontaires se prêtent à l’exercice pour cette étude qui prend fin le vendredi 1 juillet.
Les résultats permettront d’établir l’utilité de ce type de prévention et sa mise en œuvre future éventuelle.
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En savoir plus...
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Pourquoi simuler au sol les effets de l’impesanteur ?
Les expériences de simulations des effets de l'impesanteur sont réalisées au sol pour mieux comprendre les mécanismes d’adaptation de l’organisme humain à l’impesanteur, pour préparer les vols spatiaux et pour mettre au point des moyens préventifs (appelés contre-mesures) des effets négatifs de l’impesanteur. 
 
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Qu’est-ce que le modèle d’immersion sèche ?
Ce modèle, mis au point et utilisé par les scientifiques russes a été utilisé pour la première fois par MEDES sur 12 sujets sains début 2015.
Ce modèle « d’immersion sèche » est intéressant car il induit des effets physiologiques que l’autre modèle de simulation plus utilisé jusqu’à ce jour, modèle d’alitement ou « bed rest », ne permet pas de reproduire fidèlement et « l’immersion sèche » est donc complémentaire de ce dernier.
 
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2003
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Terminé
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Etude des effets du confinement sur le corps humain
Evaluation de la prise de risque en condition dégradée
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ESA, CNES
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Cette étude a été réalisée en 2003 par MEDES pour l'Agence Spatiale Européenne et pour le Centre National d'Etudes Spatiales.
Elle a été mise en place dans le but d'étudier et évaluer l'influence de la composition des équipages (de vols habités) sur la perception et la prise de risque dans des conditions de stress hypnique et chronobiologique.
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Contexte de l'étude
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La prise de risque est un problème clé en termes de sécurité pendant les vols spatiaux ; en particulier pour les missions de longue durée et/ou interplanétaires. Ce secteur de recherche a aussi beaucoup d’applications dans l’amélioration de la sécurité des systèmes homme/machine.
On sait qu’il existe des différences importantes entre les hommes et les femmes dans la perception et la prise de risque. Par ailleurs, la prise de risque est influencée par les troubles du sommeil et les perturbations chronobiologiques qui sont des facteurs importants de l’environnement spatial.
Les astronautes ont tendance à dormir moins et les modifications de l’exposition lumineuse (éclairage faible des véhicules spatiaux et changements de l’alternance lumière-obscurité (rapide en orbite basse) peuvent affecter leurs rythmes circadiens. Des fluctuations de la vigilance peuvent conduire à des changements au niveau de la perception et de la prise de risque.
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Objectifs de l'étude
Dans le cadre de la préparation des missions de longues durées et de la perspective de missions interplanétaires, l’objectif de ce projet est d’estimer la vulnérabilité à la prise de risque de 12 volontaires sains de sexe masculin comparée à celle de 12 volontaires sains de sexe féminin dans des conditions de privation de sommeil et de stress chronobiologique.
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Deroulement de l'étude
Les conditions de stress chronobiologique ont été réalisées par un isolement et un confinement de 8 jours au sein de la Clinique Spatiale, associé à des conditions d’éclairage artificiel de faible intensité telle que celle recommandée pour les véhicules spatiaux (recommandations NASA pour les véhicules spatiaux).
Une privation aiguë de sommeil de 24 heures a été réalisée à la fin de cette période d’isolement et de confinement.
Les volontaires ont subi également une privation aiguë de sommeil sans isolement et confinement préalables afin d’évaluer les seuls effets de cette privation.
Les 24 volontaires sains ont été répartis en 4 groupes de 6 (3 hommes et 3 femmes par groupe).
Une batterie de tests permettant d’évaluer la prise de risque, le niveau de vigilance et de performance a été réalisée pendant les 8 jours d’isolement et confinement avant et après la privation de sommeil, et après privation de sommeil non précédée d’une période de confinement (conditions de vie habituelles avec horaires veille-sommeil contrôlés).
Les conséquences des conditions de stress que représentent la privation aiguë de sommeil et le stress chronobiologique ont été évaluées également au niveau des systèmes endocrinien et immunologique (cortisol et cytokines dosés dans la salive), et de la régulation du système cardiovasculaire par le système nerveux autonome (variabilité de la fréquence cardiaque)
 
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Conclusions
Les résultats de cette recherche sol ont eu pour but de permettre de préciser les conséquences de la privation de sommeil et du stress chronobiologique sur la prise de risque, les performances, et les paramètres physiologiques liés au stress.
A terme, les résultats ont pour objectif de permettre une meilleure organisation de la composition des équipages des vols spatiaux et de l’attribution de tâches en fonction des risques encourus entre les hommes et les femmes.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2013
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Terminé
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Etude des mécanismes de régulation cardiovasculaire en position debout et des effets d’une  stimulation mécanique plantaire
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MEDES a mené entre janvier et mars 2013 une étude clinique appelée Orthoboots auprès de 12 volontaires hommes.
Les principaux objectifs de cette étude ont été :

d’étudier les mécanismes de régulation cardiovasculaire en position debout (orthostatisme) afin d'améliorer la prise en charge des patients présentant des malaises fréquents
et
d’évaluer les effets d’une stimulation mécanique plantaire sur la réponse du système cardiovasculaire au passage à la position debout (réalisée grâce aux chaussures de stimulation plantaire « Korvit »).

Au cours de ce protocole, il a également été testé une nouvelle stratégie thérapeutique applicable dans les pathologies veineuses, dans des troubles de la motricité et comme moyen préventifs des troubles induit par un voyage dans l’espace.
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Equipements utilisés
Allongé sur une table de tilt (sorte de lit pouvant se relever mécaniquement), le sujet a également été équipé des chaussures de stimulation plantaire ainsi que des divers capteurs destinés à mesurer les paramètres suivants :

	
la pression artérielle,
	
l’activité électrique de votre cœur (électrocardiogramme – ECG)
	
la fréquence respiratoire,
	
le flux sanguin cutané,
	
une évaluation échographique d’une veine de la jambe placée derrière le genou
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2011
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Terminé
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Etude sur l'efficacité de médicaments dans la privation du sommeil
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Cette étude s'est inscrite dans le cadre du projet Européen PharmaCog, qui marque le début d’un ambitieux partenariat entre public et privé visant à faire progresser la recherche pharmaceutique dans la maladie d’Alzheimer.
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Contexte
La maladie d’Alzheimer est un trouble cérébral évolutif qui entraîne un déclin progressif et irréversible de la mémoire et des fonctions cognitives. A l’heure actuelle, les effets des médicaments disponibles pour traiter la maladie d’Alzheimer sont modestes, d’où la nécessité de développer de nouveaux produits agissant sur les symptômes.
Les scientifiques concentrent leur attention sur le développement de critères/marqueurs cognitifs/mnésiques utilisés dans un certain nombre de modèles expérimentaux induisant de manière artificielle des troubles transitoires et proches de ceux observés dans la maladie d’Alzheimer.
Le recours à la privation totale de sommeil est ainsi un bon candidat en tant que modèle physiologique. Différentes études de privation de sommeil totale ont été réalisées chez le volontaire sain allant de 24 à 72h. Le modèle de 24h de privation de sommeil semble être le meilleur candidat.
Le projet a duré 6 ans (2010-2015). MEDES est intervenu sur une étude clinique en début de projet.
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Objectifs
Le projet avait pour objectifs principaux de  :

Evaluer si la privation de sommeil constitue un modèle éventuel de troubles cognitifs  en évaluant si des molécules sont capables de pallier à ces troubles.
Tester les effets de récupération d’une dose unique de modafinil, tester les effets du donépézil et de la mémantine sur les fonctions cognitives de sujets jeunes et en bonne santé privés de sommeil.
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Déroulement de l'étude
Cette étude a été réalisée sur 12 volontaires de sexe masculin âgés de 25 à 40 ans. Ils ont vécu 5 hospitalisations de 48 heures chacune.

Partie A : période 1 et 2 espacées de 7 jours. (J-1, arrivée à la Clinique à 16h00, examen médical, mise en place électrodes, prise de sang – J1 : privation de sommeil : prise de modafinil.)
Partie B : 3 hospitalisations de 48 heures chacune séparées d’une période de 6 semaines avec une prise de médicaments pendant 13 jours avant l’arrivée à la Clinique. Prise de Motilium pendant 15 jours pour éviter les troubles digestifs.
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Pour aller plus loin
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Le projet PharmaCog, sur le site IMI (Innovative Medicines Initiatives)
Rapport final du projet (2015)
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2018 - 2021
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude clinique d'évaluation d'une crème biologique
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MEDES, les Jardins du Girou, Elkarkide, 
Univ Saragoza, de Huesca, de Pamplona, Valentia
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SPAGYRIA est un projet de coopération transfrontalière qui, par l’intermédiaire d’un réseau de centres d’emploi spécialisés et de centres de recherche, vise à étendre la culture de plantes aromatiques et leur traitement en laboratoire, ainsi que la recherche de procédés innovants par le biais de technologies totalement durables pour le développement de produits cosmétiques naturels.
Ce projet, d'une durée de 4 ans (2018 - 2021), est cofinancé par le Fonds Européen de Développement Régional (FEDER).
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Cultiver nos différences, puiser dans nos ressources, en créer une richesse...
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Dans le détail…
Spagyria, c’est :

Un projet qui vise à créer une nouvelle chaîne de production d’extraits de plantes pour la production de produits cosmétiques écologiques.
Un projet solidaire qui implique des personnes en situation de handicap ou en difficulté d’insertion, et qui contribuera à la fois à améliorer leur employabilité et ainsi leur qualité de vie.
Un futur label de certification écologique (bio-handicap)
La capitalisation d’expériences et le développement économique des partenaires de chaque côté transfrontalier tant au niveau de la culture et du conditionnement des plantes aromatiques, qu’au niveau des process d’extraction, de fabrication et de test.
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Implication de MEDES dans le projet
MEDES est intervenu dans ce projet lors de la phase de conception du projet et ensuite dans un second temps pour la réalisation concrète de l’étude clinique, une fois les phases de développement et de recherche d’actifs cosmétiques réalisés par les centres de transformation et de traitement.
L'étude clinique a été réalisée fin 2021.
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Les partenaires du projet
 
 
 
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Pour aller plus loin
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Consultez le site web dédié au projet
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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Etude de l'efficacité d'un pantalon thermorégulateur chez des femmes présentant une insuffisance veineuse légère.
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2007
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude de l'efficacité d'un tissu intelligent
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AVELANA, KLIMEO, MEDES
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But de l'étude
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De nombreux sujets et essentiellement des femmes souffrent d’insuffisance veineuse.  Les manifestations cliniques sont très variables et souvent négligées par le patient et son médecin.
Les symptomes sont majorés en période estivale avec l’accroissement des températures.
L’entreprise AVELANA, fabriquant des textiles féminins a mis au point un nouveau tissu thermorégulateur appelé KLIMEO. Grace à ses caractéristiques thermorégulatrices, ce tissu permet de diminuer la sensation de froid ou de chaud lorsque l’on passe dans un environnement thermique différent.
L'étude a été réalisée à la clinique MEDES entre juillet et août 2007.
Le but principal de cette étude a été de comparer l’efficacité sur le plan thermique du pantalon thermorégulateur KLIMEO par rapport à un pantalon neutre (placebo) et d’évaluer le confort global et l’évolution de l’insuffisance veineuse de sujets féminins présentant une insuffisance veineuse légère.
L’effet du tissu thermorégulateur KLIMEO a été évalué sur les membres inférieurs de sujets présentant une insuffisance veineuse modérée.
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Le Pantalon KLIMEO utilisé pour l'étude
Le tissu KLIMEO appartient à la gamme de « tissus intelligents » et possède des propriétés thermorégulatrices.
Sur les fibres du tissu sont greffées des microcapsules, invisibles à l’œil nu, contenant un actif naturel de thermorégulation. Ce produit actif de thermorégulation change de phase en fonction de la température extérieure. Ainsi dans un environnement froid, les microcapsules passent en phase solide en restituant de la chaleur et limitent donc la baisse de température, donnant ainsi une sensation de chaud sur la peau.
A l’inverse dans un environnement chaud, les microcapsules passent en phase liquide en absorbant de la chaleur et limitent donc la montée en température, donnant donc une sensation de frais sur la peau.
Ces changements de phases sont totalement transparent pour l’utilisateur et l’avantage de cette technique de greffage permet la succession respectives des phases dès le changement de température.
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Objectif de l'étude
 
L’objectif principal de l’étude était de mesurer la température cutanée et de suivre son évolution dans des ambiances thermiques standardisées et de les comparer selon le type de pantalon (KLIMEO ou neutre).
Les objectifs secondaires ont été d’évaluer l’efficacité du pantalon thermorégulateur sur le confort global du sujet (stress...) et sur l’insuffisance veineuse légère.
 
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Déroulement de l'étude

Vingt personnes ont participé à cet essai.
La participation a compris :

Une visite de sélection réalisée dans les 28 jours précédant l’évaluation du pantalon,
Deux visites d’évaluation correspondant à l’évaluation de paramètres physiologiques permettant d’apprécier le rôle thermorégulateur du pantalon (par mesure thermique), le rôle sur le confort physiologique (paramètres cardio-respiratoire) et veineux (questionnaire d’appréciation). La première visite a permis d'évaluer le premier pantalon et la deuxième visite a permis d'évaluer celui qui n’avait pas été testé la première fois.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" global_colors_info="{}"]
Urgent ! Recrutement volontaires
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2008
2010
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude de la prise de médicament sur la vigilance 
(en conduite simulée)
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Assistance publique des hopitaux de Marseille, 
MEDES
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MEDES a réalisé en 2007-2008 puis en 2010, 2 études sur les effets de la prise d'un médicament "Medico-Médicament" puis de la consommation de cannabis "Médico-Cannabis" sur les performances et les comportements associés à la conduite.
Pour cela, les performances de conduite ont été évaluées et comparées de deux façons :

d’abord en condition expérimentale sur un simulateur reproduisant la conduite automobile,
puis en condition réelle de conduite sur un segment autoroutier.

La conduite en condition simulée a été testée dans les locaux de la Clinique Spatiale, équipée d’un simulateur reproduisant la conduite automobile. La conduite réelle a été testée sur un tronçon autoroutier à Bordeaux.
Le promoteur de l’étude est l’Assistance Publique des Hôpitaux de Marseille. MEDES a coordonné sa mise en œuvre pour la partie “conduite simulée”.
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Objectifs des études

"Médico-Médicaments" (2007-2008)
Cette étude a eu pour objectif d’évaluer chez le sujet sain les effets d'une prise unique d'un médicament de la classe des benzodiazepines (à fort potentiel d'endormissement), sur l'aptitude à la conduite en condition simulée et réelle.
"Médico-Cannabis" (2010)
L'objectif de cette étude a été  de décrire de façon précise et objective les effets de la consommation de cannabis sur les performances et les comportements associés à la conduite. En effet, les effets comportementaux du cannabis, en particulier la somnolence et le ralentissement des comportements ont incité à étudier leur retentissement en termes de conduite de véhicules.
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Déroulement des études
Lors de la conduite simulée, le volontaire a été installé dans un poste de pilotage et une scène visuelle lui a été présentée sur un écran. Le volontaire a été invité à conduire en maintenant sa trajectoire au centre de la voie de droite sauf cas de dépassement, et en maintenant une vitesse constante. Pendant le trajet, différents paramètres de conduite ont été mesurés (variation de vitesse, le franchissement de lignes, la déviation latérale).
Lors de la conduite réelle, le volontaire a conduit un véhicule et était accompagné pendant tout le trajet par un co-pilote expérimenté et un personnel habilité à effectuer des prélèvements sanguins. La conduite s'est effectuée sur une portion d'autoroute (trajet Langon-Agen). Le trajet a été enregistré à l'aide d'une caméra fixée dans la voiture et les paramètres de conduite ont été analysés ensuite.
Pour chaque sujet la durée de participation a été de 4 sessions :

2 sessions qui se sont déroulées à MEDES (enceinte du CHU Toulouse Rangueil) espacées d'une semaine environ,
2 sessions de conduite réelle espacées également d'une semaine, qui ont eu lieu sur une portion d'autoroute à Bordeaux.

 A chaque fois, une des 2 sessions s'est déroulée avec la prise de médicament ou de cannabis, et l'autre sans. La session où a été administrée le médicament ou cannabis et la session sans n'était connue ni du volontaire, ni du scientifique.
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Bénéfices attendus de ces études
Le but de ces recherches est de mieux évaluer l'impact réel de la prise de médicament de la classe des benzodiazepines ou de la prise de cannabis sur la conduite automobile, et d'améliorer les méthodes d'investigation permettant de tester ce type de substances dans le champ de la santé et de la sécurité routière.
A plus long terme, on peut envisager que ces procédures expérimentales soient proposées pour tester de façon routinière toute molécule ayant un potentiel délétère sur la conduite automobile. L’objectif ultime de cette recherche est d’améliorer la qualité de la sécurité routière et de réduire les risques d’accidents de la circulation liés à la consommation de substance "pharmacologiquement" actives, on peut espérer contribuer ainsi à la réduction des coûts humains et financiers liés aux accidents.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2021
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude des effets des vols spatiaux sur le corps humain
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ESA
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MEDES a mené pour l'ESA une nouvelle étude de simulation de l’impesanteur utilisant le modèle d’« Immersion sèche » sur un panel exclusivement féminin !
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Au dernier trimestre 2021 a eu lieu une nouvelle étude clinique durant laquelle 20 volontaires femmes, âgées de 20 à 40 ans, ont passé 5 jours « en immersion » dans le cadre d’une étude clinique d’immersion sèche, un modèle de simulation de l’impesanteur, visant à recréer certains effets des vols spatiaux sur le corps humain. Cette campagne a démarré le 21 septembre 2021 avec les deux premiers sujets dans nos locaux de la Clinique Spatiale.
Les volontaires ont été placées dans des bassins semblables à des baignoires et recouverts d’un tissu imperméable pour les garder au sec et avec une pression de l’eau qui s’exerce de façon uniforme sur toute la surface corporelle. En conséquence, l’organisme humain l’interprète comme une « absence complète d’appui » – une situation semblable à ce que vivent les astronautes dans la Station Spatiale Internationale.
C’est seulement la deuxième fois qu’une campagne d’immersion sèche a eu lieu sur des sujets exclusivement féminins, et c’est une première en Europe. L’ESA a décidé de mener cette étude, appelée VIVALDI, pour combler l’absence de données scientifiques sur les femmes.
« Dans ce domaine de recherche, il n’y a presque aucune connaissance sur les effets physiologiques et psychologiques sur les femmes. Une étude d’immersion sèche portant exclusivement sur des femmes s’ajoutera aux études précédentes portant sur des hommes, menées en Europe et en Russie », explique Angélique Van Ombergen, responsable des sciences de la vie à l’ESA.
Les volontaires ont vu leurs mouvements limités dans un environnement contraint et ont fait l’expérience de changements dans leurs fluides corporels et dans leur mobilité ainsi que dans la perception de leur propre corps.
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Une journée en "immersion"
L’immersion commence lorsque l’eau recouvre le sujet au-dessus du thorax, immobilisé avec le reste du corps recouvert d’une bâche de coton imperméable. Seuls les bras et la tête ne sont alors pas couverts par la bâche.
Les volontaires passent près de 24 heures par jour dans le bassin d’immersion, où leurs mouvements sont limités autant que possible. Chaque journée commence à 7 heures du matin avec prise d’échantillons biologiques et comprend de nombreux protocoles et mesures scientifiques appliquées pour étudier l’adaptation du corps à ce nouvel environnement.
Toutes les activités, des loisirs à la toilette, sont réalisées dans les limites de l’immersion. Seul un petit oreiller est autorisé pendant les repas pour les faciliter. La douche et le transfert des sujets vers des tests ou examens spécifiques se font à l’extérieur du bassin et les sujets demeurent alors couchés sur le dos avec la tête inclinée à 6 degrés vers le bas pour minimiser les déplacements de fluides.
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Pourquoi une immersion sèche ?
En impesanteur, le corps des astronautes perd de la densité musculaire et osseuse, la vue peut subir une détérioration et on observe une redistribution des fluides dans l’organisme qui se déplacent notamment vers le cerveau. Trouver des moyens de rester en bonne santé en orbite fait l’objet d’une grande partie de la recherche liée à l’exploration spatiale humaine.

Les résultats de ce type de recherche profitent non seulement aux astronautes pour étudier les effets néfastes des vols spatiaux sur l’organisme, mais ils sont aussi bénéfiques pour les patients sur Terre atteints de troubles similaires et pour les personnes âgées.

Les résultats de cette étude seront connus en 2022.[/et_pb_text][/et_pb_column][et_pb_column type="1_3" _builder_version="4.18.0" _module_preset="default" background_image="https://www.medes.fr/wp-content/uploads/2022/05/Dry-Immersion-21-09-2021.jpg" global_colors_info="{}"][et_pb_image src="https://www.medes.fr/wp-content/uploads/2022/05/Dry-Immersion-21-09-2021.jpg" alt="Dry Immersion - 21-09-2021" title_text="Dry Immersion - 21-09-2021" force_fullwidth="on" disabled_on="off|off|on" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}"][/et_pb_image][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" module_class="sectionFixe" _builder_version="4.18.0" _module_preset="default" background_color="RGBA(255,255,255,0)" positioning="none" position_origin_f="center_right" horizontal_offset="0px" custom_padding="0px||0px||true|false" custom_css_main_element="position: fixed !important;||right: 0 !important;||left: unset !important;||top: 57%!important;||transform: translateY(-50%);" locked="off" global_colors_info="{}"][et_pb_row use_custom_gutter="on" gutter_width="1" make_equal="on" _builder_version="4.18.0" _module_preset="default" width="100%" max_width="100%" custom_padding="0px||0px||true|false" custom_css_main_element="    overflow: visible !important;" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}"][et_pb_blurb image="https://www.medes.fr/wp-content/uploads/2023/04/Sans-titre-18.png" icon_placement="left" image_icon_width="50px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#ffae00" image_icon_custom_margin="||||false|false" image_icon_custom_padding="|14px|||false|false" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/ressources/actualites/" global_colors_info="{}"]
Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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Projet Moonirs - Etude activité cérébrale
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2023
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Terminé
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Evaluation de la circulation cérébrale et la charge cognitive des astronautes
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CNES, SpaceshipFR, MEDES
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Le contexte
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L’environnement spatial, et particulièrement la micropesanteur, entraînent des modifications qui sont susceptibles d’affecter les performances des astronautes. Les futures missions d’exploration spatiale lointaine vers la Lune et Mars seront de plus amenées à exposer les astronautes à de fortes charges mentales en les exposant à divers facteurs de stress (isolement géographique, fortes contraintes physiques et psychiques, etc). Ceci peut nuire aux capacités cognitives et même présenter un risque pour la santé mentale et les performances de l’équipage.
Il parait dès lors nécessaire de surveiller et évaluer la santé comportementale de l’équipage et prévoir l’impact potentiel sur leur performance. 
Afin d’évaluer la capacité à quantifier la charge de travail mentale dans l’espace, une étude a ainsi été proposée au sol, en condition de micropesanteur simulée (par alitement anti-orthostatique), grâce à un capteur portatif placé sur le front (capteur infrarouge appelé NIRS pour Near Infrared Spectroscopy). L’activité cérébrale induite par une tâche consomme en effet une certaine quantité de ressources en oxygène liées à la difficulté de la tâche, et cette demande de ressources peut être quantifiée et mesurée.
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Cette étude a été menée par le SpaceShipFR (programme du CNES) et réalisée par les équipes MEDES dans les locaux de la Clinique Spatiale de MEDES. L'étude a par ailleurs bénéficié du support et de l'expertise de l'équipe du CHU de Purpan, de l'équipe de l'INSERM Paris et de l'équipe du CHU d'Angers pour divers examens médicaux.
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Objectifs de l'étude
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Les objectifs principaux de l’étude étaient :

démontrer la faisabilité de l’évaluation de la charge de travail mentale en condition de micropesanteur simulée par fNIRS portable,
évaluer si les paramètres de la fNIRS ne sont pas modifiés par les modifications de la circulation cérébrale, évaluées en utilisant de nouvelles techniques ultrasoniques qui permettent une imagerie du cerveau humain adulte à l’échelle microscopique.

Cette étude cherche également à quantifier et comparer la charge cognitive associée à une même tâche mentale en condition de micropesanteur simulée et en position allongée.
Les résultats de cette étude pourront être utilisés pour implémenter un capteur permettant de mesurer la charge cognitive de l’équipage pour les futurs vols spatiaux.
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Déroulement de l'étude
 
Pour le CNES, cette étude a été réalisée à l’automne 2023 au sein de la Clinique Spatiale. Neuf femmes et neuf hommes ont participé à cette étude.
Après une visite de sélection, chaque volontaire a participé à 2 visites de tests permettant d’évaluer les paramètres de circulation cérébrale en alitement anti-orthostatique (Head-Down Tilt) :

sans charge cognitive supplémentaire
avec charge cognitive supplémentaire : le volontaire devra alors réaliser une tâche nécessitant la mobilisation de ressources cognitives et/ou physiques (questionnaire notamment utilisé pour évaluer la charge de travail d’astronautes et pilotes dans le cadre d’études similaires) puis évaluer la difficulté perçue à la réalisation de la tâche

Le volontaire était allongé sur une table de tilt et a été incliné progressivement avec plusieurs paliers d’inclinaison différente : 0°, -10°, -20°, suivi d’un retour à 0°. Chaque palier a eu une durée de 20 minutes.
 
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Perspectives
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La spectroscopie fonctionnelle à infrarouge (fNIRS) est une alternative particulièrement intéressante aux méthodes d’exploration cérébrale type IRM, difficilement envisageable lors de vols spatiaux. C’est une technologie de mesure de l’activité cérébrale non invasive, et qui fournit une mesure d’oxygénation sanguine en temps réel via la mesure de l’intensité optique. Étant facile à utiliser, portative, peu coûteuse et sûre pour les mesures à long terme et répétées, la fNIRS est un outil prometteur pour les vols spatiaux de longue durée.
L’utilisation de ce type de capteur à bord de modules spatiaux pourrait ainsi permettre à terme de surveiller et d’évaluer la santé comportementale de l’équipage, notamment pour les futures missions lunaires et martiennes.
Les résultats de l’étude MONNIRS permettront d’avancer sur ces problématiques.
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Pour aller plus loin
 
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En savoir plus sur les activités du SpaceshipFR (programme du CNES) ?
 
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En savoir plus sur la clinique spatiale de MEDES, son infrastructure et ses activités ?
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2011-2013
[/et_pb_blurb][et_pb_blurb title="Etat d'avancement :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Réalisation d'un modèle de contrôle de la biocontamination en environnement clos
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MEDES, SCK CEN, IBM, IBMP, VTT, UEF
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Le projet BIOSMHARS (BIOcontamination Specific Modelling in HAbitats Related to Space) est un projet de recherche qui a duré 2 ans, co-financé par la Commission Européenne dans le cadre du 7ème Programme Cadre. 
Il a démarré fin 2011.
6 partenaires ont été impliqués dans ce projet. MEDES était notamment en charge de la coordination du projet.
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Objectifs du projet
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Le projet BIOSMHARS visait à développer, calibrer et valider un modèle mathématique pour prédire le transport des bioaérosols dans un environnement fermé et la propagation simultanée de biocontamination. Ce modèle se donnait pour objectif de soutenir la mise en œuvre de contre-mesures proactives.
BIOSMHARS a été la première phase d'un effort de recherche conjointe Europe-Russie afin de développer des outils scientifiques et techniques pour une approche globale de la question complexe de la biocontamination à l'intérieur des vaisseaux spatiaux habités.
L'objectif à long terme était alors d'améliorer la stratégie de contrôle de la biocontamination dans les vaisseaux spatiaux avec des applications possibles pour les environnements fermés sur terre.
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Les partenaires du projet
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Poster scientifique
 
Présentation du projet lors de la Human Space Conference.
MEDES a décroché le 3ème prix de la Poster Session suite à la présentation de son poster pour le projet.
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Poster scientifique
[/et_pb_text][et_pb_text content_phone="
Poster scientifique
 
Présentation du projet lors de la Human Space Conference.
MEDES a décroché le 3ème prix de la Poster Session suite à la présentation de son poster pour le projet.
" content_last_edited="off|desktop" _builder_version="4.21.0" _module_preset="default" header_2_text_align="center" text_orientation="center" header_2_text_align_tablet="center" header_2_text_align_phone="left" header_2_text_align_last_edited="on|phone" text_orientation_tablet="center" text_orientation_phone="left" text_orientation_last_edited="on|phone" global_colors_info="{}"]Présentation du projet lors de la Human Space Conference.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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BONUS - Prévention de la fragilité musculosquelettique
Modèles et services de présélection in vitro et in vivo pour les interventions spatiales et terrestres contre la fragilité musculaire et osseuse (BONUS)
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2020 - 2023
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Terminé
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Prévention de la fragilité 
osseuse et musculaire
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MEDES, Sainbiose Inserm UMR 1059, Bari University, Genova University & Ospedale Policlinico San Martino, University of Cambridge, Elveflow, GreenBone Ortho, Stemnovate, Atlantic Bone Screen, Kayser Italia
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CONTEXTE
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Malgré un entraînement physique intensif, les astronautes présentent encore des altérations de la microarchitecture osseuse qui ne sont pas encore toutes réversibles au cours de l'année qui suit le retour de l'ISS sur Terre.
Sur Terre, le vieillissement et la sédentarité de la population s'accompagnent souvent de sarcopénie (perte de masse et de force musculaire) et d'ostéoporose (faiblesse osseuse).
De nouvelles stratégies thérapeutiques prometteuses sont nécessaires pour agir sur les deux branches du système musculo-squelettique.
Dans ce contexte, pendant près de quatre ans, l'équipe BONUS, composée d'universitaires et d'industriels, a étudié des stratégies thérapeutiques agissant sur l'appareil locomoteur, en particulier l'utilisation potentielle de l'irisine. 
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DESCRIPTION
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Le développement de nouvelles stratégies thérapeutiques ou de nouvelles contre-mesures spatiales nécessite des modèles de présélection efficaces avec des modèles in vitro et in vivo avancés capables de simuler le déconditionnement musculo-squelettique et l'ostéosarcopénie. Les modèles existants de simulation de la microgravité peuvent être d'une grande valeur ajoutée dans ce contexte, bien que des modèles 3D avancés de remodelage osseux, hautement contrôlés, doivent encore être développés. De tels modèles devraient être promus dans les offres de services industriels intégrés pour la présélection de nouvelles molécules pour l'industrie pharmaceutique ou nutritionnelle.
L'objectif de BONUS était double :

étudier le potentiel de l'irisine pour de nouvelles thérapies ou des contre-mesures spatiales
proposer une approche intégrée avec des modèles et des outils de simulation avancés pour le présélectionnement de nouvelles molécules contre l'ostéosarcopénie.

Le consortium a combiné une expertise académique de haut niveau avec des entreprises, fournissant des atouts pour cette offre de service intégrée ainsi qu'un opérateur de services de recherche préclinique pour l'industrie.
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PERSPECTIVES
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Ce projet a donc montré un important potentiel scientifique et économique pour des applications terrestres telles que l'utilisation de l'irisine pour des traitements médicaux, tout en fournissant des connaissances scientifiques avancées pour comprendre les changements induits par les vols spatiaux liés aux systèmes physiologiques des astronautes et leurs mécanismes et processus sous-jacents, dans le but d'élaborer des contre-mesures efficaces pour les missions de longue durée.
Les résultats du projet conduisent déjà à de nouvelles expériences de pré-conditionnement des sujets avec une combinaison d'entraînement physique et de suppléments nutritionnels pour une meilleure récupération après un vol spatial de longue durée.
Le projet permet également de mieux comprendre le lien entre certaines protéines telles que l'"irisine" et la vascularisation des os. Cela pourrait avoir une application pour les fractures osseuses des astronautes lors des missions dans l'espace lointain.
Dans le cadre de ce projet, deux publications ont déjà été publiées et d'autres sont à venir : 
- Impact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism (FASEB journal, 2022)
- Effets de la décharge sur les muscles et les os en fonction du temps et implication de l'axe FNDC5/irisine (NPJ Microgravity, 2023).
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Pour aller plus loin
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ESA : https://www.esa.int/
Sainbiose Inserm UMR 1059: https://sainbiose.univ-st-etienne.fr/fr/bto/espace.html 
Bari University: https://www.uniba.it/it/ricerca/dipartimenti/dimepre-j 
Genova University & Ospedale Policlinico San Martino: https://dimes.unige.it/ 
University of Cambridge: https://www.ceb.cam.ac.uk/research/groups/bst 
Elveflow: https://www.elveflow.com/ 
GreenBone Ortho: https://greenbone.it/ 
Stemnovate: https://stemnovate.co.uk/ 
Atlantic Bone Screen: https://www.atlantic-bone-screen.com/language/en/ 
Kayser Italia: http://www.kayser.it/ 

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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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2020 - 2023
[/et_pb_blurb][et_pb_blurb title="Etat d'avancement :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
En cours
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Système d'aide à la décision pour la santé de l'astronaute
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ESA, MEDES, New Clin, Heverett Group
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L’objectif du projet est de réaliser un démonstrateur technologique d’un système expert qui fournit un support d’aide à la décision pour la santé de l’astronaute.[/et_pb_text][/et_pb_column][et_pb_column type="1_3" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}"][et_pb_image src="https://www.medes.fr/wp-content/uploads/2023/01/Logo_CHIMS.png" title_text="Logo_CHIMS" _builder_version="4.19.3" _module_preset="default" width="100%" module_alignment="right" global_colors_info="{}"][/et_pb_image][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" custom_padding_last_edited="on|tablet" module_id="Expériencephysiologie" module_class="section_offre_stage" _builder_version="4.20.2" _module_preset="default" background_color="#ededed" custom_padding="70px||70px||true|false" custom_padding_tablet="50px||50px||true|false" custom_padding_phone="50px||50px||true|false" locked="off" global_colors_info="{}"][et_pb_row column_structure="1_2,1_2" module_class="col_margin_bottom overflowVisible flexTab" _builder_version="4.20.2" _module_preset="default" min_height="151.6px" custom_padding="0px||0px||true|false" global_colors_info="{}" custom_css_main_element_last_edited="on|tablet" custom_css_main_element_tablet="display: block !important;" custom_css_main_element_phone="display: block !important;"][et_pb_column type="1_2" _builder_version="4.20.2" _module_preset="default" custom_padding_tablet="||25px||false|false" custom_padding_phone="||25px||false|false" custom_padding_last_edited="on|tablet" global_colors_info="{}"][et_pb_text admin_label="Le projet" _builder_version="4.20.2" _module_preset="default" header_font="Oswald light||||||||" custom_margin="0px||30px||false|false" custom_margin_tablet="||25px||false|false" custom_margin_phone="||25px||false|false" custom_margin_last_edited="on|tablet" global_colors_info="{}"]
Le projet
[/et_pb_text][et_pb_text _builder_version="4.20.2" _module_preset="default" global_colors_info="{}"]L’application CHIMS couvre les fonctionnalités suivantes :

	
Donner des recommandations à l’astronaute sur la pratique de ses activités à bord de la station, en fonction des besoins médicaux spécifiques à l’astronaute et ses préférences.
	
Donner des recommandations à l’astronaute sur sa prise alimentaire à bord de la station, en fonction des besoins médicaux spécifiques à l’astronaute, ses préférences et la disponibilité des aliments à bord.
	
Apporter les indications en direct sur la gestion à l’astronaute dans le cadre d’une urgence médicale et de soins à réaliser sur un de ses collègues.

Pour réaliser cette application, il a été décidé d’implémenter un système expert. Cet outil d’intelligence artificielle vise à implémenter la connaissance d’experts (nutritionniste, médecin de vol, ingénieur biomédical, physiothérapeute dans notre cas) dans un logiciel qui sera ensuite capable de fournir une aide à la décision à ses utilisateurs, comme le ferait ces experts du domaine.

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CHIMS, en tant que démonstrateur technologique à TRL 4, vise à montrer l’intérêt de l’utilisation de cet outil dans le cadre des vols habités. Pour rappel, la nutrition et l’exercice physique sont des contremesures quotidiennes utilisées par les astronautes afin de diminuer l’impact de la micropesanteur sur le corps humain. De plus, lors de futurs voyages vers la Lune et Mars, la communication en temps réel avec la Terre ne sera plus possible. Ainsi, grâce à CHIMS, les astronautes pourront avoir plus d’autonomie dans la prise nutritionnelle, la réalisation de leur sport au quotidien mais aussi la gestion d’urgence médicale à bord. 
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Les partenaires du projet
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MEDES
	
New Clin
	
Heverett Group
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Le rôle de MEDES
[/et_pb_text][et_pb_text _builder_version="4.20.2" _module_preset="default" global_colors_info="{}"]MEDES intervient à plusieurs niveaux dans le projet :

	
MEDES est le porteur de projet et en charge de la coordination du Consortium et du projet. 
	
MEDES fournit son expertise sur les trois domaines : nutrition, exercice physique et urgence médicale.
Il a notamment réalisé l’état de l’art qui a permis de cadrer l’orientation scientifique et technique du projet. Pendant le développement du prototype, MEDES apporte sa contribution sur la conception du modèle de vol, qui n’est pas réalisé pendant le projet, et participe à fournir une partie des données utilisées par le logiciel via EveryWear. 
	
MEDES est également responsable de la validation du prototype dont la campagne de tests sera réalisée en coopération avec l’ESA.
	
Enfin, MEDES fournira les conclusions et recommandations sur la suite des activités à réaliser.
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CHIMS, en tant que démonstrateur technologique à TRL 4, vise à montrer l’intérêt de l’utilisation de cet outil dans le cadre des vols habités. Pour rappel, la nutrition et l’exercice physique sont des contremesures quotidiennes utilisées par les astronautes afin de diminuer l’impact de la micropesanteur sur le corps humain. De plus, lors de futurs voyages vers la Lune et Mars, la communication en temps réel avec la Terre ne sera plus possible. Ainsi, grâce à CHIMS, les astronautes pourront avoir plus d’autonomie dans la prise nutritionnelle, la réalisation de leur sport au quotidien mais aussi la gestion d’urgence médicale à bord. 
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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Projet DIABCARE
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2018-2019
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Terminé
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Conception d'une unité médicale mobile
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SRT, Diamip, Mipih, MEDES, Toutenkamion
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Contexte
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La Société Réunionnaise de Télémédecine (SRT) et l’association AURAR souhaitaient se doter d’une unité mobile de type véhicule pour la mise en place d’un service de dépistage itinérant des complications du diabète sur le territoire de la Réunion. 
MEDES, le MiPiH et le Réseau DIAMIP disposaient d’une expérience et compétence dans la mise en place de ce type de véhicule et du service de dépistage associé, grâce notamment au service DIABSAT opérationnel depuis plusieurs années en région Occitanie. L’entreprise Toutenkamion est spécialisée dans la conception d’unités mobiles et de véhicules sur mesure.
L'objectif a été de fournir le véhicule et les équipements nécessaires au dépistage itinérant, ainsi que la fourniture du support nécessaire pour l’utilisation opérationnelle du camion pendant 1 an. 
 
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Un véritable savoir-faire transférable
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MEDES a acquis une forte expertise dans ce domaine. En effet, MEDES implémente depuis de nombreuses années des solutions de télémédecine mobiles, flexibles, particulièrement adaptées au suivi de patients à domicile ou en mobilité. 
MEDES met ainsi son savoir-faire et son expertise au service de plus grand nombre.
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Dans le détail...
 
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Des unités médicales sur mesure
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Ces unités mobiles sont spécialement conçues pour l’institution qui utilisera la solution.
L'aménagement de ces unités est totalement modulable et elles sont dotées de l’ensemble des équipements biomédicaux nécessaires au suivi du patient. Ces unités peuvent ainsi convenir pour de multiples besoins et spécialités médicales.
Par exemple, dans le cas d'un camion destiné au suivi des complications du diabète, il sera équipé entre autres d’un rétinographe, d’un analyseur de masse corporelle, d’une plateforme de podo barométrie, d’un appareil de diagnostic vasculaire ou encore d’analyseurs biologiques… Pour le confort des patients et des soignants, il est également équipé d’un accueil, d’une cabine de consultation, d’un point d’eau et de la climatisation réversible permettant une utilisation efficiente et confortable et un accueil dans les meilleures conditions.
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Un transfert de données facilité
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Les données recueillies sont transférées pour interprétation à des spécialistes dans un centre expert référent.
Elles peuvent être transmises de façon sécurisée par les réseaux traditionnels 4G ou de WIFI, mais également grâce à l’utilisation d’une antenne satellite additionnelle.
À distance, l’expert analyse les données. Ses conclusions et la conduite à tenir sont ensuite envoyées au médecin traitant qui peut alors adapter le traitement.
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Une exploitation efficiente
[/et_pb_text][et_pb_image src="https://www.medes.fr/wp-content/uploads/2022/06/Exploitation-efficiente.jpg" alt="Exploitation efficiente" title_text="Exploitation efficiente" show_in_lightbox="on" _builder_version="4.20.2" _module_preset="default" global_colors_info="{}"][/et_pb_image][et_pb_text admin_label="Par ailleurs, pour une exploitation" _builder_version="4.20.2" _module_preset="default" module_alignment="left" text_font_size_phone="14px" locked="off" global_colors_info="{}"]
Par ailleurs, pour une exploitation le plus simple possible, il a été choisi d'opter pour un gabarit de camion de type véhicule léger. Cela permet ainsi une charge peu onéreuse pour l'institution. Son gabarit lui permet par ailleurs d'être conduit par l’infirmier lui-même, ne nécessitant ainsi pas l’intervention d’une tierce personne.
L’infirmier peut alors sillonner les routes à la rencontre des patients. Le camion s’installe dans les villages, et les patients, informés de sa venue par les mairies, les pharmaciens ou les médecins traitants, peuvent venir consulter.
Le professionnel de santé réalise sur place une batterie d’examens.
[/et_pb_text][et_pb_text admin_label="Une solution qui améliore" module_class="dateModule" _builder_version="4.20.2" _module_preset="default" header_text_color="#115994" header_font_size="55px" header_2_font="||||||||" header_2_text_align="center" header_2_text_color="#000000" header_2_font_size="55px" header_3_text_align="left" background_enable_color="off" custom_margin="||10px|-21px|false|false" custom_margin_tablet="||10px|-21px|false|false" custom_margin_phone="||0px|-20px|false|false" custom_margin_last_edited="on|phone" custom_padding="|||20px|false|false" animation_direction="bottom" header_3_line_height_tablet="" header_3_line_height_phone="" header_3_line_height_last_edited="on|desktop" animation_duration_tablet="0ms" animation_duration_phone="0ms" animation_duration_last_edited="on|tablet" animation_intensity_slide_tablet="" animation_intensity_slide_phone="0%" animation_intensity_slide_last_edited="on|phone" locked="off" global_colors_info="{}"]


Une solution qui améliore le suivi médical : un véritable atout dans le parcours de soins du patient
[/et_pb_text][et_pb_text admin_label="En s’intégrant dans le parcours" _builder_version="4.20.2" _module_preset="default" module_alignment="left" text_font_size_phone="14px" locked="off" global_colors_info="{}"]
En s’intégrant dans le parcours de soins du patient, ces unités médicales mobiles permettent de lutter efficacement contre la désertification médicale. Elles favorisent par ailleurs le maintien à domicile. Elles incitent à la consultation, permettent de réduire les délais de prise en charge des patients et améliorent leur confort en réduisant leurs déplacements. En prévenant les complications de certaines pathologies et en améliorant le suivi médical, les unités mobiles permettent enfin de réaliser de réelles économies.
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En images...
 
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      ["post_content"]=>
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LBNP - Contremesure spatiale
Nouveau dispositif mobile de pression négative dans le bas du corps (Lower Body Negative Pressure) pour l'entraînement orthostatique en microgravité
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2021 - 2024
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En cours
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Contremesures aux effets de la microgravité 
pendant les vols spatiaux habités de longue durée
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MEDES, Safran Aerosystems, CNES-CADMOS
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CONTEXTE
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Lors des vols spatiaux avec équipage, lorsque les astronautes sont exposés à la microgravité pendant une longue période, leur corps est soumis à de nombreux changements tels que le déplacement des fluides corporels vers la tête. 
L'objectif du LBNP mobile est de fournir une contre-mesure à ce phénomène.
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DESCRIPTION
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Piloté par l'ESA, le nouveau LBNP proposé par le consortium(MEDES/SAFRAN/CNES est destiné à déplacer les fluides corporels vers les parties inférieures pendant que l'utilisateur effectue des activités et des exercices quotidiens. 
En tant que contre-mesure, l'utilisation du LBNP vise à prévenir :

 l'intolérance orthostatique après le vol
le déconditionnement cardiovasculaire
l'apparition du syndrome neuro-oculaire associé au vol spatial (appelé SANS).

Le prototype est composé d'un pantalon pour créer une pression négative autour des parties inférieures du corps et d'une pompe alimentée par une batterie.
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CONTRIBUTION DE MEDES
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Dans le cadre de ce projet, MEDES assure :

la coordination du projet : MEDES est la principale interface avec l'ESA et tous les partenaires du consortium
l'état de l'art pendant les premières étapes des projets
la préparation et l'exécution de la campagne de validation incluant les volontaires au sein de la clinique spatiale.


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PERSPECTIVES
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Le prototype devrait être complètement achevé courant 2024 après une campagne de validation impliquant des volontaires à la clinique spatiale. 
Si les résultats sont conluants, de nouvelles éditions du LBNP pourraient être produites pour être utilisées rapidement dans le cadre d'études cliniques de simulation de l'impesanteur telles que des alitements ou des immersions sèches. 
Enfin, un modèle de vol du LBNP mobile devrait être produit pour être utilisé par les astronautes dans l'espace pendant la durée de la mission.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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2014-2018
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Prévention des crises sanitaires dans les hubs de transport
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MEDES, APHP, public Health England, 
Université Finlande de l'est, Institut finlandais VTT
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Prévention et gestion des agents pathogènes à haut risque dans les hubs de transport
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Le projet visait à développer des outils et des recommandations pour l’aide à la gestion des crises sanitaires dans les hubs de transports (aéroports, ports et gares).
L'objectif est d'aider les opérateurs de transport et les acteurs concernés dans les principales plaques tournantes du transport à élaborer leurs plans de préparation et d'intervention en cas de pandémie et de pathogènes dangereux.
Le projet a été financé par la Commission Européenne (Programme cadre FP7, Thème Sécurité SEC-2013.2.2-2). Il s'est étalé de 2014 à 2018.
Le projet a adopté une approche proactive pour la prévention contre les agents pathogènes.
Comme point de départ, PANDHUB s'est engagé à identifier les "zones prioritaires" (hotspots) qui présentent un risque de transmission des microbes plus élevé via la respiration, l'éternuement et le toucher. Le projet a identifié ces zones en étudiant les voies de transmission potentielles des infections, les flux de passagers, et les caractéristiques uniques des zones de transport très fréquentées.
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Partenaires du projet
Le projet comptait parmi ses partenaires : l’APHP (SAMU de Paris), MEDES-IMPS (Institut de Médecine et de Physiologie Spatiale), le ministère de la santé Anglais (Public Health England), l’Université de Nottingham (Health Protection and Influenza Research Group),  et l’Université de Finlande de l’Est. Il est coordonné par l’institut Finlandais VTT.
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Contribution de MEDES
 
MEDES a contribué à ce projet en développant le système PANDHUB, une solution permettant de configurer et obtenir des outils de collecte de données très flexibles.
Dans le contexte du projet, ce système est utilisé en support aux activités liées aux enquêtes épidémiologiques, à la recherche de contacts et à la gestion des épidémies.
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Pour aller plus loin
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La solution développée dans le cadre du projet est à l'origine de la plateforme de collecte de données DATAMIA. 
En effet, en plus des contextes d’utilisation ciblés par le projet PANDHUB, le système peut être utilisé dans de nombreux autres contextes, à chaque fois qu’il y a besoin d’organiser des campagnes de collecte de données, comme la recherche clinique, la médecine du travail, la gestion de crise, etc.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2013-2014
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Terminé
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Développement de technologies innovantes 
pour la médecine personnalisée
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MEDES, ITA, CHU Toulouse
Univ Lisbonne, CETEMMSA, CONETIC
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Description du projet
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Le projet TEMIS est un projet transnational de 21 mois réalisé en 2013-2014 et dans lequel ont été impliqués 6 partenaires.
Il a été réalisé grâce au cofinancement de l’Union Européenne et du fond Spécifique FEDER, ainsi que du programme de coopération territoriale SUDOE.
Son objectif : proposer des innovations technologiques abordables, faciles d’utilisation et accessibles au plus grand nombre, pour évaluer par des mesures objectives le mode de vie d’une personne et ainsi contribuer à préserver sa santé et lui proposer de nouveaux services de médecine personnalisée.
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Technologies TEMIS
Les technologies proposées par TEMIS visaient à permettre de quantifier et qualifier l’activité physique ou encore à caractériser les mouvements des membres d’une personne. Ces technologies ont permis d'associer également les traitements de données nécessaires pour définir les indicateurs utiles à la fois à la personne et au médecin, ainsi que la plateforme logicielle pour gérer les échanges de données et fournir les indicateurs pertinents pour les différents utilisateurs possibles. Les technologies proposées présentaient l'avantage de pouvoir être utilisées soit combinées, soit séparément, afin de répondre à différentes conditions médicales ou maladies.
La R&D a été plus particulièrement ciblée sur :

une application utilisant le capteur Kinect (capteur associé à la console de jeu Xbox) pour caractériser les mouvements des membres corporels pour des pathologies neurologiques,
une solution plus légère pour la mesure d’activité physique en ambulatoire en utilisant un smartphone, éventuellement combinables avec un T-Shirt intelligent fournissant des paramètres vitaux (respiration, rythme cardiaque, température de la peau)
et enfin une plateforme logicielle gérant les échanges et traitements de données et la fourniture des services associés.

Ces technologies ont évalué sur des populations avec différents niveaux d’activité physique : 40 sujets sains jeunes, 20 sujets obèses, 40 personnes âgées et 30 patients Parkinsoniens, le recrutement des volontaires ayant eu lieu à la fois au Portugal et en France.
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Le projet TEMIS repose sur la définition de technologies simples, innovantes mais peu coûteuses et accessibles pour quantifier et qualifier le mode de vie d’une personne, afin de fournir des indicateurs de santé pouvant ensuite être utilisés pour une médecine plus personnalisée. 
TEMIS, à travers l'implication de 6 partenaires a proposé de développer de telles technologies, de les tester sur des sujets sains et patients, tout en assurant le transfert vers des industriels et fournisseurs de services.
 
Retrouvez ci-joint une vidéo de présentation du projet.
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Les innovations technologiques
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Partenariat
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Le projet TEMIS a répondu aux exigences du programme SUDOE et a correspondu à une initiative conjointe de R&D qui intègre différentes régions et projets communautaires en réseaux et/ou renforcent le système d'investigation-innovation, améliorant la position internationale des régions dans des domaines d'intérêts communs.
Ainsi 6 partenaires européens ont été impliqués dans ce projet et ont représenté 3 pays transfrontaliers : la France, l'Espagne et le Portugal.
 
Le partenariat dans le détail :

MEDES – Institut de Médecine et de Physiologie Spatiales : chef de file, développement des applications sur smartphone et intégration de la plateforme logicielle
Instituto Tecnológico de Aragón Area Operaciones Division Tecnologicas Multimedia (ITA) : développement de l’application sous Kinect
Centre Hospitalier Universitaire de Toulouse (CHUT) : spécifications médicales, évaluations sur des sujets sains et sur des patients.
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina Universidade de Lisboa / Faculdade de Medina : spécifications médicales et évaluation sur des sujets sains et des patients.
Fundació CETEMMSA : développement du sous-système vêtement intelligent
Confederacion Española de Tecnologias de la Informacion Comunicaciones y Electronica (CONETIC) : animation du réseau de coopération, promotion vis-à-vis des industriels.
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Pour aller plus loin
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Guide d'utilisation du dispositif TEMIS
Site web SUDOE
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2019-2021
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.5" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Developpement d'application pour améliorer le suivi de maladies chroniques pour les enfants
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MEDES, RéPPOP
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Le projet TiChron a eu pour objectif le développement d’outils destinés à améliorer la prise en charge globale des enfants atteints de maladies chroniques.
Il a été porté par le programme SUDOE, sur une durée de 2 ans. 6 partenaires ont participé dont 2 côté français.

Les partenaires auront ainsi fourni aux enfants, aux familles et aux aidants des outils optimisés pour les soins et l’action précoce en cas d’apparition d’anomalies dans leur état de santé. Cela s'est traduit notamment par la création d’un Chatbot, le développement d’un jeu interactif et d’un outil de e-learning.




Objectifs du projet
TiChroN a eu pour ambition d'aborder de manière globale les problèmes identifiés dans le suivi, le traitement et l’autonomie des enfants atteints de maladies chroniques, en se fondant sur les TIC et en impliquant les secteurs de la société qui interagissent régulièrement avec ces enfants.
Le projet a fourni aux enfants, aux familles et aux aidants des outils optimisés pour les soins et l’action précoce en cas d’apparition d’anomalies dans leur état de santé.
Le caractère innovant du projet se reflète dans les différentes activités proposées, qui placent le patient au centre du projet :

Analyse des besoins spécifiques des enfants et des acteurs qui les entourent
Conception d'outils TIC ergonomiques et interactifs dédiés à la population cible (enfants, adolescents), habituée aux technologies
Création de protocoles communs et optimisés, et formation pour toutes les parties prenantes impliquées
Etude pilote des outils et de protocoles d’essais dans les 3 pays
Analyse des résultats pour définir les meilleures pratiques
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Résultats attendus

Nouveaux avantages et services de cybersanté
Amélioration de la qualification des professionnels de la santé résultant de l’échange de bonnes pratiques internationales
Économies de coûts et d’organisation grâce à la réduction des erreurs
Consolidation des réseaux internationaux pour l’incorporation de la cybersanté
Développement du réseau d’affaires dans le secteur des TIC, augmentation de la compétitivité et de l’activité économique des régions SUDOE
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Implication de MEDES
MEDES a participé au développement d’outils d’aide au suivi des enfants atteints de maladies chroniques et a notamment développé 2 applications :

Application Mobile pour les enfants
Cette application permet d’établir des conversations types conçues par les équipes médicales partenaires du projet. Elles permettent :

Planifier des exercices physiques et les évaluer
Evaluer la quantité et la qualité du sommeil
Evaluer le suivi de la glycémie par l’enfant
Evaluer le suivi de l’asthme par l’enfant


Application Web à destination des équipes médicales
Destinée aux équipes médicales, l’application web permet :


D’inclure l’enfant dans le programme suivi
De consulter et exporter les données saisies par l’enfant via le chatbot


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Le partenariat
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Partenaires principaux :

Le Service de Santé de Cantabrie
Le Centre des Technologies de l’Information et de la Communication (CTIC)
Future Balloons
L'université de Minho
MEDES
ACCOMIP-RéPPOP (Association de prise en Charge Concertée des Obésités en MIdi-Pyrénées – Réseau de Prévention et de Prise en charge de l’Obésité Pédiatrique en Midi-Pyrénées)
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Partenaires associés :

Federación Cántabra de Personas con Discapacidad Física y Orgánica
Telefonica España S.A.U
Consejería de Educación, Cultura y centros educativos, Red de escuelas promotoras de salud
creSco – Université Paul Sabatier, Toulouse
Centre Hospitalier Universitaire de Toulouse
Centro Hospitalar e Universitário de Coimbra
Enfance Adolescence et Diabète – C. H. U de Toulouse
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Le projet Tichron a été réalisé grâce au cofinancement de l’Union Européenne et du programme de coopération territoriale SUDOE.


Pour en savoir plus sur le projet : https://www.tichron.eu
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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Depuis 2000
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En cours
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Mise en oeuvre d'un réseau de télémédecine
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MEDES, CNES, CHAR
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En 2000, un partenariat entre le Centre Hospitalier Andrée Rosemon de Cayenne (CHAR), le Centre National d’Etudes Spatiales (CNES) et l’Institut de Médecine et Physiologie Spatiales (MEDES) a permis la mise en place d'une expérimentation de télé-consultation par satellite.
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Les résultats de l’expérience s'étant avérés probants, la Guyane s’est dotée d’un véritable réseau de télémédecine. 

Ce réseau s’est enrichi au fur et à mesure de nouveaux services.Il concerne 19 centres de santé équipés et 10 disciplines médicales. Pour poursuivre ces objectifs destinés à favoriser le désenclavement sanitaire, MEDES conduit, en collaboration avec le Centre hospitalier de Cayenne, le maintien des dossiers médicaux partagés déployés dans les centres de santé isolés de Guyane. Plus de 30000 patients ont consulté dans les centres délocalisés de prévention et de soin (CDPS) en 2021.

Ce réseau est une référence historique pour MEDES, mais aussi pour la télésanté de façon plus générale. Aujourd’hui encore, ce réseau est cité comme un modèle pour les départements et territoires d’Outre Mer.
 
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Historique du projet
En 2000, la Guyane était pourvue de peu de professionnels de santé, de plateaux techniques et moyens de télécommunications limités, avec les grands centres accessibles uniquement par voie fluviale ou aérienne… Pour les populations de l’intérieur du département, la prise en charge sanitaire restait bien en-deçà des services offerts aux citadins.
Pour pallier cet état de fait et faciliter l’accès des populations isolées à des spécialistes, il avait alors été envisagé de recourir à la télémédecine. Une expérience d’évaluation s’est donc déroulée en Guyane de décembre 2001 à mai 2002, avec la mise à disposition d'une valise de télémédecine.
[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row custom_padding_last_edited="on|phone" _builder_version="4.20.2" _module_preset="default" custom_padding_tablet="" custom_padding_phone="||0px||false|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.19.5" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.20.2" _module_preset="default" global_colors_info="{}"]Il s’agissait :

L’installation du module de surveillance épidémiologique et de suivi d’activité,
La création d’une passerelle entre le serveur de télémédecine et le serveur de résultats du Laboratoire de l’Hôpital de Cayenne permettant un gain de temps et une automatisation de l’envoi des résultats d’analyses au centre de santé concerné.
L’extension du réseau aux centres de santé du littoral pour éviter, notamment en dermatologie, de longs déplacements.
La mise en place d’un réseau « médecine de ville-hôpital » impliquant les médecins libéraux.
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Exemple de cas
La cardiologie est un exemple-type d’utilisation de la téléconsultation (grâce en particulier à l’électrocardiogramme numérique joint au dossier), permettant aux spécialistes hospitaliers et au personnel soignant local de décider de traiter les patients sur place en toute sécurité, ou de procéder à une évacuation et d’en évaluer l’urgence.
On rencontre en Guyane de nombreuses pathologies parasitaires (paludisme, parasitoses intestinales…) et dermatologiques (leishmanioses, dermatoses diverses…). Ce type d’atteinte peut généralement être efficacement diagnostiqué à distance, d’où l’intérêt du système de télémédecine dans ces domaines.
Sur l'exemple ci-contre (un petit enfant présentant un important impétigo de la face), l’évacuation sanitaire a pu être évitée grâce au diagnostic porté sur la base de la photographie et au traitement par antibiothérapie prescrit par le spécialiste.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2021
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.5" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Suivi médical et des expériences de physiologie de la mission Alpha
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ESA, CNES
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En 2016, Thomas Pesquet effectuait son 1er vol spatial avec la mission Proxima.
Au printemps 2021, il volait à nouveau lors d’une nouvelle mission de 6 mois, baptisée Alpha.
Plus d’une dizaine d’expériences ont été développées et accompagnées par le CADMOS/CNES, qui gère également l’ensemble des expériences de physiologies à bord de la station, quelles que soient les missions et l’astronaute qui les réalise.
Pour le compte du CNES, l’équipe MEDES en poste au CADMOS s’est impliquée dans le suivi de ces expériences spécifiques à Alpha.
Par ailleurs, MEDES est intervenu au plus près de l’astronaute et a assuré le suivi médical de Thomas Pesquet lors de son vol.
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De la préparation sur Terre au suivi dans l’espace
Pour le compte du CNES, l’équipe MEDES sur site CADMOS s’est fortement investie dans ces expériences spécifiques à Alpha : préparation et suivi avec les scientifiques, spatialisation des expériences, rédaction des procédures, formation de l’astronaute…
Une fois les expériences préparées pour la mission en lien avec les équipes scientifiques responsables des expériences, les équipes ont assuré le support opérationnel à la réalisation de ces expériences à bord de l’ISS.
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Un accompagnement au plus près de l’astronaute
MEDES a assuré le suivi médical de Thomas Pesquet lors de son vol.
Cela a notamment consisté à être présent pendant les phases de préparation, lors de la période quarantaine avant vol, pour assurer un suivi régulier pendant la mission, puis à l’atterrissage et lors du suivi post-vol.
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MEDES s’est également impliqué dans les phases de communication autour de la mission : participation aux  émissions live lors des sorties extravéhiculaires, café Alpha à la Cité de l’espace, interviews auprès de très nombreux médias pour parler des expériences françaises, mais également de l’Homme dans l’espace et ses  bouleversements physiologiques…
Motivation, expertise, engouement, implication...toute une équipe au service de la réussite de cette aventure spatiale exceptionnelle !
 
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2016
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Terminé
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Expériences scientifiques en micropesanteur
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CNES, MEDES
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Proxima est le nom de la 1ère mission de l'astronaute Thomas Pesquet. Après une sélection en 2009, puis de longues années d'entraînement, Thomas Pesquet est parti pour sa première mission le 15 novembre 2016, de Baïkonour, pour une durée de 6 mois.

Il a été le 10ème français à s'être envolé dans l'espace et le 4ème à séjourner à bord de la Station spatiale internationale. Aucun astronaute de nationalité française n'était monté à bord de l'ISS depuis le dernier séjour de Léopold Eyharts en 2008. Un événement donc !
Lors de son séjour à bord de l'ISS, il a réalisé de nombreuses expériences scientifiques. Il a contribué en effet à 62 expériences coordonnées par l'ESA et le CNES, ainsi qu'à 55 autres expériences des agences spatiales américaines, canadienne et japonaise. Un programme chargé, à quoi sont venues s'ajouter les séances quotidiennes de sport, les repas, les moments de détente, de sommeil...
Les expériences réalisées pour la science européenne ont eu pour objectifs de faire avancer la connaissance du corps humain, la biologie et la physique, et à démontrer de nouvelles technologies à bord de l'ISS.
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MEDES et Proxima
 
MEDES  a participé à la mission Proxima à travers son soutien au centre CADMOS du CNES pour la préparation puis le suivi d'expériences, notamment dans le domaine physiologique et au Centre des astronautes européens (EAC), à Cologne, pour le suivi de l’entraînement et l’accompagnement médical des astronautes.
En plus d'une équipe MEDES détachée au Cadmos, MEDES a directement contribué à la préparation de quelques-unes des 7 expériences qui ont été entièrement préparées et suivies par le CNES.
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Focus sur les expériences réalisées avec le support de MEDES
L’application logicielle Everywear assure un suivi physiologique, médical et nutritionnel des astronautes à bord de l’ISS. Couplée à un ensemble de capteurs biomédicaux, cette application est un peu l’assistant médical  de l’astronaute ![/et_pb_blurb][et_pb_blurb image_icon_background_color="#444444" image="https://www.medes.fr/wp-content/uploads/2022/11/2.png" icon_placement="left" image_icon_width="185px" content_max_width="80%" image_icon_width_tablet="125px" image_icon_width_phone="125px" image_icon_width_last_edited="on|tablet" content_max_width_tablet="100%" content_max_width_phone="100%" content_max_width_last_edited="on|tablet" admin_label="Le dispositif..." module_class="resume_supportMission" _builder_version="4.20.4" _module_preset="default" body_text_align="right" body_text_color="#444444" animation="off" body_text_align_tablet="right" body_text_align_phone="center" body_text_align_last_edited="on|phone" global_colors_info="{}"]
Le dispositif Aquapad a pour but de tester une nouvelle façon d’analyser l’eau grâce à un outil de diagnostic novateur. Tout aussi efficace que le système actuel il apporte plus de rapidité et de simplicité d’utilisation.
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Le dispositif Matiss a pour objectif de tester de nouvelles surfaces intelligentes en micropesanteur. Ces surfaces réagissent à l’approche de bactéries en les empêchant de se poser, de proliférer et de créer les biofilms qui les protègent dans un environnement hostile.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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Accompagnement de projets CNES
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2019 - ...
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En cours                             
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.24.0" _module_preset="default" header_text_color="#444444" custom_margin="|-17px||||" animation="off" locked="off" global_colors_info="{}"]
Apporter un support et une expertise en physiologie pour la réalisation de projets menés par le CNES
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CNES
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ECHOFINDER
Assistant échographique autonome
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Depuis 1982, l’échographie est la seule technique d’imagerie disponible à bord des vols spatiaux habités. Elle est largement utilisée pour soutenir la recherche scientifique et la surveillance médicale des phénomènes physiologiques induits par la microgravité. Mais les contraintes liées aux futurs vols spatiaux (durée accrue, éloignement, temps de communication...) nécessitent de nouveaux systèmes médicaux pour assister les astronautes lors des séances d’échographie.
C’est dans ce cadre-là que le CNES a développé EchoFinder, un assistant à la réalisation d’images échographiques en complète autonomie et sans expertise médicale.
Depuis 2019, MEDES accompagne ainsi le CNES dans la réalisation et le suivi de ce projet très prometteur.
Echofinder est composé d’un système de réalité augmentée qui fournit un guidage en temps réel vers un positionnement idéal de la sonde préalablement enregistré. En parallèle, un processus de vision par ordinateur composé à la fois d’une analyse d’image physique et d’une solution basée sur l’apprentissage automatique permet de détecter et segmenter les organes ciblés. Le logiciel de réalité augmentée a notamment été testé au sol et lors d’une campagne de vol parabolique.
Aujourd’hui, une solution complète et fonctionnelle fonctionnant sur une tablette est proposée.
 
Projet CNES, en partenariat avec Sonoscanner, SFR, Université Paris Descartes, Vermon, CERCOM-Université de Tours et MEDES.
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PHYSIOTOOL
Nouvelle instrumentation de physiologie pour l'ISS
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Le CNES mène le projet dont l’objectif est de réaliser une étude de faisabilité ayant pour but la définition d’une nouvelle instrumentation de physiologie à bord du module Columbus de l’ISS (Station spatiale Internationale).
Celle-ci se veut versatile et regroupera des instruments destinés à l’étude des systèmes cardiovasculaire, musculaire et métabolique ainsi qu’à des expériences en neurosciences.
La possibilité de couplage avec d’autres instruments déjà déployés, tels que le système EveryWear ou un échographe, est également évaluée.
Dans un premier temps, cette instrumentation pourra être utilisée à bord de l’ISS jusqu’à 2025 voire 2028. Elle pourra être implémentée dans l’EPM (Euopean Physiology Modul), ou rester indépendante de ce module. Son champ d’application pourra ensuite s’étendre aux explorations spatiales sur la Lune et sur Mars.
MEDES accompagne le CNES dans la mise en oeuvre de son projet en apportant son expertise et savoir-faire en médecine et physiologie spatiales.
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Pour aller plus loin
 
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En savoir plus sur les activités du CNES ?
 
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En savoir plus sur les activités du CADMOS, centre du CNES, pour lequel MEDES apporte son support
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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