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2015
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Ended
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Study of the effects of spaceflight on the human body
Study of dry immersion as a simulation model
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CNES
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Unique in Europe ! 
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MEDES has conducted a clinical study on behalf of CNES. The objective was to study a ground simulation model called "dry immersion" concerning the effects of weightlessness. 
This was the very first study using the dry immersion model in Europe !
The model was developed and used by Russian scientists. Until now, it had not been truly studied in Europe, where the "bed rest" model is more commonly used. MEDES has already carried out many studies of this type, testing prevention methods such as exercise, adapted nutrition, a drug solution, artificial gravity, vibration exercises, etc.
 
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This new "dry immersion" model seemed interesting because it apparently induces certain physiological effects that the bed-rest model cannot faithfully reproduce and would therefore complement the latter.
The key advantage of dry immersion is its ability to simulate a support-free environment; the support is spread uniformly across the whole body area. The human body interprets dry immersion as being free of any kind of support, a situation comparable to that of real microgravity. The other factors acting simultaneously on the human body during immersion are linked to the lack of virtually all physical activity, due to a decrease in movements, the absence of body weight and the pressure of the water. The dry immersion model also makes it possible to quickly reproduce the effects of weightlessness on the sensory, motor and cardiovascular systems.
The CNES therefore decided to carry out this initial study – considered as a pilot study – to assess the effects of this model and its value.
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How the study was conducted
 
The subjects were installed in a sort of bath (2.10m x 1.10m x 0.85m) that had been specially designed for this use and filled with water. A special elastic waterproof fabric was fixed on the outside edge of the tub to stop the subjects from touching the water.
The study was conducted in February 2015, on the premises of the Space Clinic. Twelve healthy, male volunteers (aged between 20 and 45) took part  in the study.
Each of the subjects remained "immersed" for 3 days. In addition to this, the volunteers spent 3 days having basic measurements carried out beforehand and then a further 2 days post-immersion in order for comparative measurement to be conducted and to allow them to recover.
Many measurement and evaluations were carried out during the study. They can be put into two categories:

Standard tests (called Baseline Core Data), which are carried out in all studies of this type,
The tests provided for in the scientific protocols.
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This study, the first of its kind, marked the use of this new weightlessness simulation model for the CNES and then for the ESA, whose recent studies have been carried out.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(19) "2019-11-30 16:56:46"
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      string(19) "2019-11-30 15:56:46"
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      string(23961) "[et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" background_enable_color="off" background_image="https://www.medes.fr/wp-content/uploads/2022/06/AdobeStock_279577524-compressed-scaled.jpg" custom_padding="40px||40px||true|false" custom_padding_tablet="30px||30px||true|false" custom_padding_phone="30px||30px||false|false" locked="off" global_colors_info="{}" custom_css_after_last_edited="off|desktop"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="|auto|40px|auto|false|false" custom_margin_tablet="||30px||false|false" custom_margin_phone="||30px||false|false" custom_margin_last_edited="on|phone" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.17.4" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.19.1" _dynamic_attributes="content" _module_preset="default" text_orientation="center" custom_margin="||14px||false|false" custom_padding="||0px|||" header_text_align_tablet="" header_text_align_phone="left" header_text_align_last_edited="on|phone" global_colors_info="{}"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[/et_pb_text][et_pb_text admin_label="MEDES a mené pour l'ESA" _builder_version="4.19.1" text_font_size="1px" background_size="initial" background_position="top_left" background_repeat="repeat" locked="off" global_colors_info="{}"]
Etude de simulation de l'impesanteur utilisant le modèle original d'immersion sèche
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2019
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Ended
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Study of the effects of space flight on the human body Countermeasure tested : venoconstrictive thigh cuffs
 
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CNES
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In the first half of 2019, 20 volunteers took part in a new study to simulate weightlessness using an original model, dry immersion.
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This model simulates the effects of weightlessness on the human body on the ground and is used to test a new preventive method designed to minimise the negative effects of weightlessness on the human body.
The study, initiated by CNES, was carried out in the MEDES Space Clinic at the Rangueil University Hospital in Toulouse.
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What is the dry immersion model?
Volunteers taking part in the study were placed in large bathtubs filled with warm water, but are insulated from it by a waterproof sheet attached to the edge of the bathtub. They were therefore surrounded by water and "floated" without any other supporting measure. This situation, interpreted by the organism as a complete lack of support, is very similar to that of microgravity.
The model thus makes it possible to quickly reproduce the effects of weightlessness on sensory-motor and cardiovascular systems.
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Five days of immersion for space research
A first study was carried out in 2015 and a second in 2016-2017. In the first study the volunteers were "immersed for three days". For the second study, the 20 volunteers were immersed for five days. The resulting physiological changes were then observed, recorded and analysed by nearly 10 scientific teams previously selected by CNES.
In particular, the aim of this new study was to get more in-depth knowledge of the physiological mechanisms involved and, in particular, to study the redistribution of body fluids caused by immersion and their repercussions on the brain and eyes.
The volunteers stayed at the clinic for 12 days for the study, divided up as follows: 

4 days of pre-immersion for basic measurements to be taken
5 days of dry immersion
3 days of post-immersion to allow for post-immersion measurements and recovery

The 10 scientific teams studied the main physiological effects of five days of dry immersion and the impact of using thigh cuffs on the following systems:

Ophthalmic system
Muscular system
Bone system
Cardiovascular regulation
Metabolism and gut flora
Cognition
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A new preventive method tested

The prevention method tested, called a countermeasure, was the use of venoconstrictive thigh cuffs. 
These compression cuffs aim to reduce the influx of fluids to the upper part of the body, as occurs in microgravity, and should thus be able to reproduce the effect of gravity on the vascular system. This could reduce some of the negative effects of weightlessness on the body, particularly for the cardiovascular and ocular systems.
This countermeasure, if it proves effective, could easily be used by astronauts, especially as it has the enormous advantage of being particularly simple and easy to implement.
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To find out more
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MEDES, a space clinic in France
Keeping our feet on the ground as we move forward in space
Dry immersion, another method of simulating weightlessness
Space travel armbands tested in the bath - Report France 3
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(24) "2019 dry immersion study"
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      string(339) "In the first half of 2019, 20 volunteers took part in a new study to simulate weightlessness using an original model, dry immersion.

This model simulates the effects of weightlessness on the human body on the ground and is used to test a new preventive method designed to minimise the negative effects of weightlessness on the human body."
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2010
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Ended
[/et_pb_blurb][et_pb_blurb title="Objectives : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Study of the effects of spaceflight on the human body
Evaluation of artificial gravity as a countermeasure
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ESA, CNES, MEDES
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In 2009-2010, MEDES carried out a bed rest study aimed at evaluating artificial gravity, created by a short arm centrifuge, to prevent the effects of weightlessness, simulated by anti-orthostatic bed rest.
The evaluation involved two centrifugation protocols used as a counter-measure to prevent the deterioration brought about in healthy men by 5 days’ anti-orthostatic bed rest.
It was an ESA-CNES study.
This study was made possible by the installation of a short-arm centrifuge on the Space Clinic's premises in 2007.
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Context
One of the aims of the current space programmes is to prepare for future manned interplanetary missions, which may last for up to 3 years (as, for example, to Mars). Exposure to the space environment and particularly weightlessness for such periods leads to physiological changes that involve the cardio-vascular, muscle, bone and neuro-sensory systems.
Preventive means, also known as “counter-measures”, are used to combat these deleterious effects of exposure to the space environment and to prepare the astronauts for their return to Earth. The current counter-measures are mostly based on physical exercise (treadmill, bicycle-ergometer) or Lower Body Negative Pressure (or LBNP, a box in which negative pressure is applied to the lower body). They had been tested in previous bed rest studies carried out at the Space Clinic.
Today, these counter-measures are used by the permanent crews of the International Space Station (ISS) who stay on board for up to 180 days. However, they are only partially effective, probably because they only involve one physiological system at a time (muscles and possibly bones for the exercise, cardio-vascular system for LBNP, etc.).
Artificial gravity therefore offers a more global approach to the counter-measures issue as it simply simulates the Earth’s gravitational environment and therefore has repercussions for all our physiological systems.
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How to study was organised ?
12 male volunteers, divided into 3 groups, took part in the study, which took place in the Space Clinic (MEDES) over three 2-week hospitalisation periods at 4 to 5-week intervals.
Each 2-week hospitalisation period included:

A 5-day ambulatory control period,
A 5-day period of anti-orthostatic bed rest (-6°),
A 5-day ambulatory recovery period

The 12 volunteers were divided into 3 groups as follows:

“Continuous centrifugation” group (4 volunteers),
“Intermittent centrifugation” group (4 volunteers),
“Control” group (4 volunteers).

Each of the volunteers changed groups during each period of hospitalisation and was therefore his or her own control subject.
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Countermeasure protocols
 
Description of the groups :

Continuous centrifugation group: Each day of bed rest, the volunteers were subjected to a 1g acceleration de 1g around their centre of gravity (pelvis) for 30 minutes in a reclining position.
Intermittent centrifugation group: Each day of bed rest, the volunteers were subjected to a 1g acceleration de 1g around their centre of gravity for 5 minutes in a reclining position. The centrifuge was then stopped for a few seconds and a new 5-minute phase identical to the previous one began. 6 5-minute phases were thus completed.
Control group: this group acted as a control for the experiment. The subjects in this group did not undergo a centrifugation session, but was used as a comparison to evaluate the effect of the 2 types of “counter-measures” on each of the volunteers.
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More information
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The centrifuge, a key piece of equipment in the Space Clinic
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Nos actualités
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2021
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Study of the effects of space flight on the human body
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ESA
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Weightlessness simulation study carried out in 2017
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For the purposes of space-related medical research, ten male volunteers are taking part in an extraordinary experiment at the MEDES Space Clinic: simulating and studying the effects of weightlessness on the human body!
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Called "Cocktail," the study is sponsored by CNES and ESA. It will last 3 months (including 60 days in bed) and take place over 2 campaigns, each involving 10 volunteers : from January to April and then from September to December 2017.
The aim of the study is to simulate conditions similar to those on manned space flights in order to test a prevention method intended to mitigate the adverse effects of weightlessness on the human body and prepare astronauts for their return to Earth.
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Prevention method
This method consists of an antioxidant and anti-inflammatory food supplement (a mixture of natural polyphenolic extracts from edible plants) that the volunteers will have to take several times a day in the form of capsules. Half of the volunteers will take the food supplement and the other half will be used as a control group, which does not therefore take the cocktail of capsules.
16 European scientific teams are taking part in the experiment. They are interested in studying the changes induced by bed rest and the effects of the prevention method, which will be tested in the following areas: the metabolism, the cardiovascular system, muscles, bones, immunology, the neurosensory system and sleep.
The study lasts 3 months and takes place in 3 phases:

15 days of measurements on each volunteer before the bed rest
2 months of anti-orthostatic bed rest tilted at -6° (the head lower than the feet)
15 days of recovery during which new post-bed-rest measurements are collected making it possible to study the effects on the body of bed rest and the counter-measures by comparing them with the measurements made before the bed rest.

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While this research is very useful for advancing space research, it also valuable for medicine on Earth. Indeed, subjecting healthy subjects to long periods of immobilisation with no physical activity allows scientists to have a better understanding of certain diseases such as obesity, diabetes or osteoporosis.
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Why bed rest at -6°?
After several decades of practical studies, it has been determined that a -6° tilt (feet slightly above the head) corresponds to what an astronaut’s body experiences in a situation ofweightlessness. This position causes the bodily fluids to move to the upper part of the body, as observed in space. This makes it possible to simulate weightlessness while keeping the subject’s feet (almost) on Earth!
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(19) "2013-12-01 08:21:16"
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2011-2013
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Development of a model for controlling biocontamination in a closed environment
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MEDES, SCK CEN, IBM, IBMP, VTT, UEF
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BIOSMHARS is a 2-year research project co-funded by the European Commission under FP7.
6 partners are involved in the parntership.
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Project objectives
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The BIOSMHARS project aims to develop, to calibrate and to validate a mathematical model to predict the transportation of bioaerosols in a closed environment and the concurrent spread of biocontamination. This model should support the implementation of proactive countermeasures.

BIOSMHARS is the first phase a joint EU-Russia research effort to develop the scientific and technical tools for a comprehensive approach to the challenging issue of biocontamination inside manned spacecrafts.

The long term objective is to improve the biocontamination control strategy in spacecrafts with possible applications for closed environments on earth.
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Project partners
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Poster scientifique
 
Présentation du projet lors de la Human Space Conference.
MEDES a décroché le 3ème prix de la Poster Session suite à la présentation de son poster pour le projet.
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Scientific poster
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Poster scientifique
 
Présentation du projet lors de la Human Space Conference.
MEDES a décroché le 3ème prix de la Poster Session suite à la présentation de son poster pour le projet.
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Presentation of the project at the Human Space Conference.
MEDES was awarded 3rd prize in the Poster Session following the presentation of its poster for the project.a
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News
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Our projects
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A question ?
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Our clinical studies
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      string(195) "The BIOSMHARS project (BIOcontamination Specific Modelling in HAbitats Related to Space) is a research project aimed at developing a model for controlling biocontamination in closed environments."
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BRACE Bed Rest study
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In progress
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Better understand the effects of microgravity on the human body
Test artificial gravity and exercise as countermeasures
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ESA, CNES, MEDES
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MEDES is currently carrying out a microgravity simulation study using the bed rest model at its Space Clinic. Commissioned by the French (CNES) and European (ESA) space agencies , the study, named BRACE (Bed Rest with Artificial gravity and Cycling Exercise), includes 12 healthy male volunteers. The study lasted 88 days (including 60 days in bed).
 
The main objective of this study is to investigate whether artificial gravity combined with a cycling exercise helps to prevent and / or reduce the physiological effects induced by 60 days of anti-orthostatic bedrest.
 
2 countermeasures are being tested:

A bicycle exercise protocol combined with a centrifugation protocol performed on the human short-arm centrifuge. The cycle ergometer exercise protocol is similar to that used on the International Space Station (ISS).
A bike exercise protocol performed alone, following a protocol identical to that performed on the centrifuge.
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Medical and scientific tests and examinations
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14 european scientific teams will assess the changes in the cardiovascular, metabolic, musculoskeletal, neuro-sensorial, haematological, and immunological systems. They have been selected by the ESA evaluation committees.
The various tests will provide a better understanding of the effects of prolonged bed rest on the various physiological systems, their interrelationships, and the effects of the two countermeasures. In addition to the measurements proposed by the scientists, a battery of standard measurements exploring the various physiological systems is also being carried out. These measures have been used for over ten years in all bedrest studies carried out in Europe. They enable us to evaluate the different countermeasures tested in the same way, and to compare their effectiveness with each other.
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Study volunteers
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The main selection and inclusion criteria were as follows:

Healthy male volunteer
Aged 20 to 45 years
No overweight nor excessive thinness with BMI (weight kg/ height m2 ) between 20 and 27 kg/m2
Height between 158 and 190 cm
Certified as healthy by a comprehensive clinical assessment
Good mental health (tests and psychological interview)
Fitness level assessment
No medical treatment
Non active smokers
No alcohol or drug dependence
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The selection will be carried out in several phases:

2 phone interviews: One preliminary selection done over the phone will be based on application email and second a medical questionnaire on the personal and family medical history.
2 selection sessions carried out at the MEDES Space Clinic: the first one comprising of clinical and paramedical examinations, and the second one focused on psychological aspects, with centrifuge testing.

At the end of the selection process, 12 candidates were selected.
12 volunteers were be allocated to one of the three compared groups:

Control group : no countermeasure protocol
Exercises group: bike countermeasures
Artificial Gravity combined with cycle ergometers group

 
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The study process
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Each volunteer is hospitalized for 88 days, including 60 days in bed.
The hospitalization period comprises:

14 days for ambulatory control period
60 days of head-down bedrest (-6°) period with or without countermeasure,
14 days for assessments and recovery after the head-down period

Furthermore, subjects will have to come back to MEDES 30, 360 and 720 days after the period of hospitalization for three follow-up visits.
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The study began on April 4 and will end in early July with 12 volunteers. An equivalent 2nd phase will be carried out in early 2024, also with 12 volunteers. Recruitment will take place in autumn 2023.
Applications will open in autumn 2023.
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More information:
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Reportage France2, 19 mai 2023 "Voyage sur Mars : préparer son corps pour ce long périple"
 	
Article ESA: "Around the bed in sixty days"

 
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News
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Our projects
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A question ?
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Become a volunteer ?
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Our clinical studies
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New volunteer recruitment for BRACE study
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BSGN LifeScience Industry Accelerator 
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2021 - ...
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In progress
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Stimulation of commercial activities in Low Earth Orbit in the field of life sciences
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ESA, MEDES, France Biotech,
ConnectbyCNES
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Description
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The BSGN LifeScience Industry Accelerator driven by the BSGN from ESA is managed by MEDES since 2021. It finds roots into ESA’s strategy for the future such as the Agenda 2025 and the Terrae Novae 2030+ Strategy Roadmap. The goal of the Business in Space Growth Network (BSGN) is to make a significant move towards the stimulation of commercial activities in Low Earth Orbit. 
The objective of the BSGN LifeScience Industry Accelerator :

stimulating a commercial space ecosystem in LEO,
focusing on projects with terrestrial challenges that can be solved using space assets,
supporting market-driven activities,
engaging new actors who are neophytes in the space sector.

To do so, ESA as launched 3 accelerators to act in different fields:

MEDES for the life sciences and biomanufacturing,
SCE for the agriculture and food,
Catapult for advanced material and manufacturing.

All accelerators are working jointly together to strength the capabilities of the program. 
 
 
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Life sciences and biomanufacturing in space market 
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Among the journey of establishing a BSGN LifeScience Industry Accelerator, one of MEDES’ first tasks was to conduct a market assessment for the life sciences and biomanufacturing fields. Main findings are presented in the adjacent figure. 
 
This market assessment demonstrated the life sciences and biomanufacturing sectors have a huge potential for conducting research in space for commercial purposes. In parallel, it demonstrated also that most of the actors of the field were not aware of how to conduct a space project. So, they see the Accelerator as a chance to access space. 
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Perspectives
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Today, the Accelerator is still under construction. MEDES aims to see the implementation of first projects in 2024. 
Ultimately, the Accelerator should be a project broker between project owners a partner such as ESA or other space agencies. To do so, the Accelerator will launch a call annually and provides accelerations services in regards of projects and partners needs and objectives. 
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More information
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Consult the following information websites:
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BSGN website
BSGN Life Sciences Industry Accelerator website

ESA Euronews video: How astronaut health studies help us Earthlings

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[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/nos-projets/" global_colors_info="{}"]Nos projets
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="u||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#5e5e5e" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/contact/" global_colors_info="{}"]Une question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/clinique-spatiale-medes/devenir-volontaire/" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]Devenir volontaire ?
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2020 - 2023
[/et_pb_blurb][et_pb_blurb title="State of progress" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
In progress
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Decision support system for astronaut health
[/et_pb_blurb][et_pb_blurb title="Partners :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
ESA, MEDES, New Clin, Heverett Group
[/et_pb_blurb][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" custom_padding_last_edited="on|phone" module_id="Preparationfuturesmissions" module_class="section_offre_stage" _builder_version="4.20.2" _module_preset="default" custom_padding="50px||50px||true|false" custom_padding_tablet="50px||50px||true|false" custom_padding_phone="40px||40px||false|false" locked="off" global_colors_info="{}"][et_pb_row column_structure="2_3,1_3" custom_padding_last_edited="off|desktop" module_class="col_margin_bottom overflowVisible flexTab" _builder_version="4.20.2" _module_preset="default" custom_padding="0px||0px||true|false" global_colors_info="{}" custom_css_main_element_last_edited="on|tablet" custom_css_main_element_tablet="display: block !important;" custom_css_main_element_phone="display: block !important;"][et_pb_column type="2_3" _builder_version="4.20.2" _module_preset="default" custom_padding_tablet="||25px||false|false" custom_padding_phone="||25px||false|false" custom_padding_last_edited="on|tablet" global_colors_info="{}"][et_pb_text admin_label="MEDES propose actuellement plusieurs offres d'emploi pour venir renforcer ses équipes." _builder_version="4.21.0" _module_preset="default" text_font_size_phone="14px" text_line_height_phone="1.5em" locked="off" global_colors_info="{}"]
The CHIMS project was commissioned by ESA: its Consortium consists of MEDES (project leader), the Heverett Group and New Clin.
The aim of the project is to produce a technological demonstrator of an expert system to provide decision support for astronaut health.
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The project
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The CHIMS application includes the following functions:

Provide astronauts with recommendations on how to perform activities on the station, based on their specific medical needs and preferences.
Provide recommendations to astronauts on their food intake on the station, based on their specific medical needs, preferences and the availability of food on board.
Provide live guidance to astronauts in the event of a medical emergency and on treatment to give to a colleague.

It was decided to build the application around an expert system. This artificial intelligence tool aims to implement the knowledge of experts (nutritionist, flight doctor, biomedical engineer, physiotherapist in our case) in a software application that will then be able to provide decision support to its users, as would these experts in their specific fields.
 
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CHIMS is a TRL 4 technology demonstrator, intended to show its potential usefulness for crewed flights. As a reminder, nutrition and physical exercise are daily countermeasures used by astronauts to reduce the impact of microgravity on the human body. In addition, on future trips to the Moon and Mars, real-time communication with Earth will no longer be possible. CHIMS will therefore give astronauts more autonomy in managing their nutritional intake, the performance of their daily sports and also medical emergencies on board.
 
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The project partners
[/et_pb_text][et_pb_text admin_label="MEDES propose actuellement plusieurs offres d'emploi pour venir renforcer ses équipes." _builder_version="4.20.2" _module_preset="default" text_font_size_phone="14px" text_line_height_phone="1.5em" locked="off" global_colors_info="{}"]

	
MEDES
	
New Clin
	
Heverett Group
[/et_pb_text][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" custom_padding_last_edited="on|tablet" module_id="Expériencephysiologie" module_class="section_offre_stage" _builder_version="4.20.2" _module_preset="default" background_enable_color="off" custom_padding="70px||70px||true|false" custom_padding_tablet="50px||50px||true|false" custom_padding_phone="50px||50px||true|false" locked="off" global_colors_info="{}"][et_pb_row module_class="col_margin_bottom overflowVisible flexTab" _builder_version="4.20.2" _module_preset="default" min_height="151.6px" custom_padding="0px||0px||true|false" global_colors_info="{}" custom_css_main_element_last_edited="on|tablet" custom_css_main_element_tablet="display: block !important;" custom_css_main_element_phone="display: block !important;"][et_pb_column type="4_4" _builder_version="4.20.2" _module_preset="default" custom_padding_tablet="||25px||false|false" custom_padding_phone="||25px||false|false" custom_padding_last_edited="on|tablet" global_colors_info="{}"][et_pb_text admin_label="Le rôle de MEDES" _builder_version="4.21.0" _module_preset="default" header_font="Oswald light||||||||" custom_margin="0px||30px||false|false" custom_margin_tablet="||25px||false|false" custom_margin_phone="||25px||false|false" custom_margin_last_edited="on|tablet" custom_padding="0px||||false|false" global_colors_info="{}"]
MEDES’s role
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MEDES is involved in the project at several levels:

As the project leader it is in charge of coordinating the Consortium and the project.
MEDES provides expertise in all three areas: nutrition, exercise and medical emergencies.
Drawing on its specialised state-of-the-art know-how it helped to frame the project's scientific and technical orientation. During the development of the prototype, MEDES helped design the flight model, which will not be built during the project, and also provides part of the data used by the software via EveryWear.
MEDES is also responsible for validating the prototype, whose test campaign will be carried out in cooperation with ESA.
Finally, MEDES will provide conclusions and recommendations for further activities. 

CHIMS is a TRL 4 technology demonstrator, intended to show its potential usefulness for crewed flights. As a reminder, nutrition and physical exercise are daily countermeasures used by astronauts 
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CHIMS is a TRL 4 technology demonstrator, intended to show its potential usefulness for crewed flights. As a reminder, nutrition and physical exercise are daily countermeasures used by astronauts to reduce the impact of microgravity on the human body. In addition, on future trips to the Moon and Mars, real-time communication with Earth will no longer be possible. CHIMS will therefore give astronauts more autonomy when managing their nutritional intake, the performance of their daily sports and also medical emergencies on board.
[/et_pb_text][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" module_class="sectionFixe" _builder_version="4.18.0" _module_preset="default" background_color="RGBA(255,255,255,0)" positioning="none" position_origin_f="center_right" horizontal_offset="0px" custom_padding="0px||0px||true|false" custom_css_main_element="position: fixed !important;||right: 0 !important;||left: unset !important;||top: 57%!important;||transform: translateY(-50%);" locked="off" global_colors_info="{}"][et_pb_row use_custom_gutter="on" gutter_width="1" make_equal="on" _builder_version="4.18.0" _module_preset="default" width="100%" max_width="100%" custom_padding="0px||0px||true|false" custom_css_main_element=" overflow: visible !important;" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}"][et_pb_blurb image="https://www.medes.fr/wp-content/uploads/2023/04/Sans-titre-18.png" icon_placement="left" image_icon_width="50px" disabled_on="off|off|off" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="#ffae00" image_icon_custom_margin="||||false|false" image_icon_custom_padding="|14px|||false|false" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/ressources/news/" global_colors_info="{}"]
News
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/our-projects/" hover_enabled="0" global_colors_info="{}" sticky_enabled="0"]
Our projects
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="u||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="#5e5e5e" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/contact/" hover_enabled="0" global_colors_info="{}" sticky_enabled="0"]
A question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/clinique-spatiale-medes/devenir-volontaire/" disabled="on" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]Devenir volontaire ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/space-clinic/clinical-studies/" hover_enabled="0" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}" sticky_enabled="0"]
Our clinical studies
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" disabled="on" global_colors_info="{}"]Urgent ! Recrutement volontaires
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Ended
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Study of the effects of confinement on the human body
Assessment of risk-taking in degraded conditions
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ESA, CNES
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This study was conducted by MEDES on behalf of ESA and CNES in 2003.
Its goal was to study and assess the influence of the composition of crews (in manned spaceflight) on risk perception and risk taking under conditions of hypnic and chronobiological stress.
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Study objectives
As part of the preparation for long duration missions and the prospect of interplanetary missions, the aim of this project was to estimate the vulnerability to risk taking of 12 healthy male volunteers compared with 12 healthy female volunteers under conditions of sleep deprivation and chronobiological stress.
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Implementation of the study

Chronobiological stress conditions were achieved through isolation and confinement lasting eight days in the Space Clinic, combined with conditions of low-intensity artificial lighting such as that recommended for spacecraft by NASA.
Acute sleep deprivation of 24 hours was induced at the end of this period of isolation and confinement.
The volunteers also underwent acute sleep deprivation without prior isolation and confinement, in order to assess the effects of this deprivation alone.
The 24 healthy volunteers were divided into four groups of six (three men and three women per group).
A battery of tests to assess risk taking, level of alertness and performance was conducted during the eight days of isolation and confinement, before and after the sleep deprivation, and after sleep deprivation not preceded by a period of confinement (normal living conditions with controlled sleep-wake hours).
The consequences of the stress conditions typified by the acute sleep deprivation and chronobiological stress were also evaluated on the endocrine and immune systems (cortisol and cytokines assayed in saliva) and on regulation of the cardiovascular system by the autonomic nervous system (heart rate variability).
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Conclusions
Les résultats de cette recherche sol ont eu pour but de permettre de préciser les conséquences de la privation de sommeil et du stress chronobiologique sur la prise de risque, les performances, et les paramètres physiologiques liés au stress.
A terme, les résultats ont pour objectif de permettre une meilleure organisation de la composition des équipages des vols spatiaux et de l’attribution de tâches en fonction des risques encourus entre les hommes et les femmes.
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[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/nos-projets/" global_colors_info="{}"]Nos projets
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="u||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#5e5e5e" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/contact/" global_colors_info="{}"]Une question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/clinique-spatiale-medes/devenir-volontaire/" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]Devenir volontaire ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.19.5" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/clinique-spatiale-medes/les-etudes-cliniques/" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}"]Nos études cliniques
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" global_colors_info="{}"]Urgent ! Recrutement volontaires
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      string(19) "2012-12-02 10:47:26"
      ["post_date_gmt"]=>
      string(19) "2012-12-02 09:47:26"
      ["post_content"]=>
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Evaluation of an ultrasonic tonometer measuring carotid and femoral artery parameters
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2012
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Evaluation of an ultrasonic tonometer measuring carotid 
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ESA, MEDES, Verhaert
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Context
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When astronauts return to Earth after space flights of various durations, they frequently encounter symptoms such as dizziness when they change position; for example when moving from a sitting to a standing position, going from lying down to standing, or even when they remain in a standing position for long periods. This is known as orthostatic intolerance. It can be explained by a loss of the cardiovascular system’s ability to maintain a sufficient supply of oxygen to the brain. Symptoms can range from dizziness through to loss of consciousness.
 
Study objectives
 
In order to better assess these phenomena at arterial level under very specific conditions (microgravity, clinical simulation studies, parabolic flights, etc.), the European Space Agency decided to develop different devices aiming to better understand and analyse the physiological mechanisms involved in these symptoms. In this regard, and working closely with scientists from the University of Ghent, the Belgian company Verhaert is developing a device that combines the principles of tonometry and Doppler ultrasound to measure different parameters that characterise the physiological condition of the arteries. In particular, this device should measure blood pressure at various sites, arterial diameter, ejection time and pulse wave velocity, all in a completely non-invasive manner.
 
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Apparatus tested : CPMM or tonometer and an ultrasound probe. This device records fine variations in pressure in relation to the sensor. It records movements linked to the heartbeat and the movement of blood in the vessels.
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Implementation of the study

Fourteen male and female subjects aged from 20 to 40 years took part in this study.
The subject lay on a kind of bed that can be mechanically lifted (a device called a tilt table). This tilt table is equipped with a “Low Body Negative Pressure” (LBNP) system, a large box in which the subject places his/her legs and pelvis. This system can then apply negative pressure (like a vacuum) to the lower part of the body. A neoprene skirt, similar to the one fitted to kayaks, ensures that the box is air-tight. A variety of equipment is then attached to the subject: ultrasound probes, tonometry sensors, Finapres monitor, Dynamap monitor, tilt table
Measurements from the LBNP during the tilt test are then recorded.
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Nos actualités
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Nos projets
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Une question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/space-clinic/become-a-volunteer/" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]
Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2009
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Ended
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Diabetes prevention
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CNES, CHU Toulouse, Diamip, MEDES,
ONSIL, IRIT, OVEA, Fleuret
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Improving diabetes management through mobility
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Alongside 8 other partners, MEDES has been involved for over 10 years in the Diabsat project, aimed at preventing diabetes.
Using satellite technology in particular, DIABSAT sets up new means to help patients on a daily basis.
Ce projet est aujourd'hui géré par l'Assiociation Dibète Occitanie. Il s’inscrit dans une démarche novatrice visant à aider à la prise en charge des patients diabétiques au plus près de leur lieu de vie et à les sensibiliser au suivi des complications chroniques.
Ainsi, un camion équipé de plusieurs appareils médicaux sillonne les départements de l'ex-région Midi-Pyrénées depuis 2010 et l’Occitanie dans son ensemble depuis 2017.
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Objectifs du projet
Le projet est parti du constat que le diabète est une maladie qui concerne de plus en plus de personnes en France et dans le monde. Les chiffres ne cessent d’augmenter et on parle de véritable épidémie. Sans une prise en charge adaptée, cette maladie peut entrainer de graves complications. Pourtant, des solutions permettent aux malades de mieux vivre avec la maladie : un dépistage précoce, un suivi médical et une modification du mode de vie (nutrition et activité physique).
Porté par des partenaires investis et un programme innovant, le projet DIABSAT a été sélectionné en mai 2009 par le Conseil régional de Midi-Pyrénées suite à un appel d’offre. Il se base alors sur une approche thérapeutique innovante et des technologies nouvelles pour la prise en charge des patients. Cela inclut :

La prévention, avec des logiciels éducatifs
Le dépistage des complications du diabète, avec une équipe mobile qui sillonne la région
Le suivi à domicile, avec un recueil d’informations à distance grâce à un téléphone portable.

MEDES a principalement travaillé sur le volet 3 du projet : le suivi à domicile.
 
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Pérénisation du projet
 
Le projet a été un franc succès et le camion développé dans le cadre du projet sillonne encore aujourd'hui les départements de la région Occitanie et les patients diabétiques peuvent bénéficier gratuitement d'examens médicaux selon leurs besoins et/ou à la demande du médecin traitant ou du diabétologue.

Depuis son démarrage en 2010, le programme DIABSAT a permis de recevoir 5 700 personnes diabétiques au cours de plus de 780 journées.

Concrètement, le réseau DIAMIP déploie le camion :


lors de campagnes départementales mises en œuvre par l’Association
lors de journées de dépistage ponctuelles « à la demande » pour la patientèle des structures qui sollicitent l’Association


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Vous pouvez retrouver le détail du programme, le calendrier des dépistages et les contacts clés sur le site DIAMIP
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News
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Our projects
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A question ?
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Our clinical studies
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" disabled="on" global_colors_info="{}"]Urgent ! Recrutement volontaires
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      string(19) "2017-12-13 13:58:21"
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2017 - ...
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In progress
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A software package for medical and nutritional monitoring of astronauts
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MEDES, CNES, ESA, NASA
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The EveryWear software application was developed for CNES for the Proxima mission, to enable medical and nutritional monitoring of astronauts on board the ISS.
Coupled with a set of biomedical sensors, the application plays the role of an actual assistant, in the form of a simple application on a touch tablet.
It has been very successful and is used continually on the station.
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EveryWear, the astronaut's assistant
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EveryWear is a scalable mobile app that allows medical and scientific data to be collected directly through the iPad that astronauts carry with them on the station and/or from a set of connected sensors.
It is used to monitor astronauts' nutrition, conduct physiology experiments via questionnaires and exchange private messages between the astronauts and the medical teams on the ground.
The app, which is highly appreciated by astronauts for its functionality, user-friendly commands and ease of use in a daily routine, is entirely operational and is now used by European astronauts for medical support and by astronauts from all space agencies when they are involved in the ten or so current experiments that use EveryWear. On the ground, EveryWear is being used in three User Support or Operational Centres (the CADMOS, ECOS and BIOTESC USOCs) as well as by the EAC medical team.
 EveryWear was used on Thomas Pesquet’s Proxima and Alpha missions.
 
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Increasing cooperation
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As a result of the positive feedback, the agencies have expressed interest in supporting the EveryWear project for future ISS missions and are considering it for the future Orion and Gateway missions.
An ESA/CNES/NASA cooperation agreement has thus been signed to continue upgrading it for current missions and at NASA's request for development of the common tool.
EveryWear is becoming the central data collection hub for ESA's Exploration Medical System.
MEDES continues to manage this project for space agencies and to coordinate and implement the technical developments.
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MEDES, technical partner
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En tant qu'intervenant technique principal, MEDES a développé dans le cadre du projet :






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To find out more
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News
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/our-projects/" hover_enabled="0" global_colors_info="{}" sticky_enabled="0"]
Our projects
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A question ?
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[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/space-clinic/clinical-studies/" hover_enabled="0" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}" sticky_enabled="0"]
Our clinical studies
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" disabled="on" global_colors_info="{}"]Urgent ! Recrutement volontaires
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2021
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Study of the effects of space flight on the human body
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ESA
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MEDES conducted a new study for ESA to simulate weightlessness, using the "Dry Immersion" model on an all-women group !
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In the last quarter of 2021, a new clinical study took place in which 20 female volunteers, aged between 20 and 40, spent five days "immersed" as part of a dry immersion clinical study, a model for simulating weightlessness, aimed at recreating some of the effects of space flight on the human body. The campaign started with the first two subjects in our Space Clinic on 21 September 2021.
Volunteers were placed in bathtub-like tanks covered with an impermeable fabric to keep them dry and with water pressure applied evenly over the entire body surface. As a result, the human body interprets it as a "complete lack of support" – a situation similar to that experienced by astronauts on the International Space Station.
This was only the second time that a dry immersion campaign had taken place on exclusively female subjects, and it was a first in Europe. ESA decided to conduct the study, called VIVALDI, to fill the gap in scientific data on women.
"In this field of research, there is almost no knowledge about the physiological and psychological effects of space flight on women. A dry immersion study involving only women will complement the previous studies involving men, conducted in Europe and Russia," explained Angélique Van Ombergen, head of life sciences at ESA.
The volunteers experienced restricted movement in a constrained environment and changes in body fluids and mobility, as well as in the perception of their own bodies.
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A day of "immersion"
Immersion begins when water covers the immobilised subject above the chest, with the rest of the body covered by a waterproof cotton sheet. Only the arms and head are not covered by the sheet.
The volunteers spend almost 24 hours a day in the immersion tank, where their movements are restricted as much as possible. Each day starts at 7am with the taking of biological samples and includes numerous scientific protocols and measurements to study the body's adaptation to this new environment. 
All activities, from recreation to washing, are carried out in the immersion tank. Only a small pillow is allowed during meals to make them easier. Subjects are allowed out of the tank for showering or specific tests or examinations, where they remain supine with their heads tilted downwards at 6 degrees to minimise internal-fluid movement.
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Why dry immersion ?
In weightlessness, astronauts' bodies lose muscle and bone density, eyesight can deteriorate and there is a redistribution of fluids in the body, particularly to the brain. Much of the research on human space exploration consists in finding ways for astronauts to stay healthy in orbit.
The results of this type of research not only benefit astronauts in studying the adverse effects of space flight on the body, but also patients on Earth with similar disorders and the elderly. 
The results of the study were programmed for 2022.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(19) "2017-01-06 14:38:33"
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      string(19) "2017-01-06 13:38:33"
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2017 - ...
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In progress
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Management of financial remuneration for clinical researchers
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MEDES, CHU Toulouse, CHU Nîmes
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Research investigators are paid by pharmaceutical companies for commercial clinical trials.
The remuneration is intended to boost research with a sufficiently broad scope by allowing clinical researchers, while carrying out their projects, to purchase equipment, supplies or services, to pay for travel, to participate in a congress, seminar, training session, etc.
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Regulatory management of financial remuneration
The government has decided to introduce a single standard contract for industrially-promoted biomedical research in public health institutions with the aim of reducing the length of time it takes to sign agreements binding the industrial sponsor of the research to the various hospital stakeholders carrying out the investigation.
This contract is unique in that it associates the industrial sponsor, the health care institution and the investigator for the same research site, but also because it is intended to be deployed in exactly the same way by all health care institutions wishing to participate in the research.
A ministerial circular, published in June 2014 (circular DGOS/PF4/2014/195), enabled implementation of the measure in public health institutions, both through the systematic use of a standard contract template, reducing the number of clauses to be negotiated, and by imposing predefined procedures for drawing up the list and amount of additional costs generated by the research. In January 2016, Article 155 of the Act on the modernisation of our health system changed the terms "single standard contract" and "financial incentives" to "single standard agreement" and "remuneration" respectively.
GIE MEDES is eligible to manage the financial remuneration, as a third-party structure, co-signatory of the standard agreement. The members approved this new activity and incorporated it into the GIE's articles of association at an extraordinary general meeting on 10 April 2015.
This activity is currently carried out by MEDES for the Toulouse and Nîmes University hospitals.
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The ASTRAM application
 
MEDES has set up a dedicated web application to allow investigators to initiate expenses, track them and access their account status via Internet. This application is compatible with the following browser releases (or later releases):

IE 11
Mozilla Firefox
Google Chrome
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For more information
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Please contact the person in charge of these activities at : + 33 (0)5 34 31 96 00.
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News
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Our projects
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A question ?
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Our clinical studies
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Since 2000
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In progress
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Set up a telemedicine network
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MEDES, CNES, CHAR
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En 2000, un partenariat entre le Centre Hospitalier Andrée Rosemon de Cayenne (CHAR), le Centre National d’Etudes Spatiales (CNES) et l’Institut de Médecine et Physiologie Spatiales (MEDES) a permis la mise en place d'une expérimentation de télé-consultation par satellite.
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Les résultats de l’expérience s'étant avérés probants, la Guyane s’est dotée d’un véritable réseau de télémédecine. 

Ce réseau s’est enrichi au fur et à mesure de nouveaux services.Il concerne 19 centres de santé équipés et 10 disciplines médicales. Pour poursuivre ces objectifs destinés à favoriser le désenclavement sanitaire, MEDES conduit, en collaboration avec le Centre hospitalier de Cayenne, le maintien des dossiers médicaux partagés déployés dans les centres de santé isolés de Guyane. Plus de 30000 patients ont consulté dans les centres délocalisés de prévention et de soin (CDPS) en 2021.

Ce réseau est une référence historique pour MEDES, mais aussi pour la télésanté de façon plus générale. Aujourd’hui encore, ce réseau est cité comme un modèle pour les départements et territoires d’Outre Mer.
 
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Project history
French Guiana had few health professionals, limited technical facilities and telecommunications, and its major centers were accessible only by river or air. For the populations of the department's interior, health care remained well below the services offered to urban residents.
To remedy this situation and facilitate access to specialists for isolated populations, the use of telemedicine was considered. An evaluation experiment took place in Guyana in the 2000s, with the provision of a telemedicine kit.
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L’installation du module de surveillance épidémiologique et de suivi d’activité,
La création d’une passerelle entre le serveur de télémédecine et le serveur de résultats du Laboratoire de l’Hôpital de Cayenne permettant un gain de temps et une automatisation de l’envoi des résultats d’analyses au centre de santé concerné.
L’extension du réseau aux centres de santé du littoral pour éviter, notamment en dermatologie, de longs déplacements.
La mise en place d’un réseau « médecine de ville-hôpital » impliquant les médecins libéraux.
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Exemple de cas
La cardiologie est un exemple-type d’utilisation de la téléconsultation (grâce en particulier à l’électrocardiogramme numérique joint au dossier), permettant aux spécialistes hospitaliers et au personnel soignant local de décider de traiter les patients sur place en toute sécurité, ou de procéder à une évacuation et d’en évaluer l’urgence.
On rencontre en Guyane de nombreuses pathologies parasitaires (paludisme, parasitoses intestinales…) et dermatologiques (leishmanioses, dermatoses diverses…). Ce type d’atteinte peut généralement être efficacement diagnostiqué à distance, d’où l’intérêt du système de télémédecine dans ces domaines.
Sur l'exemple ci-contre (un petit enfant présentant un important impétigo de la face), l’évacuation sanitaire a pu être évitée grâce au diagnostic porté sur la base de la photographie et au traitement par antibiothérapie prescrit par le spécialiste.
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News
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Our projects
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A question ?
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[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/space-clinic/clinical-studies/" hover_enabled="0" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}" sticky_enabled="0"]
Our clinical studies
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2020 - ...
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In progress
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Development of a mobile app to prevent 
the loss of autonomy in seniors
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OMS, ARS, CHU Toulouse, Gérontopole Toulouse,
MEDES (technical partner)
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MEDES was asked by the Gérontopôle of the Toulouse University Hospital, a WHO Collaborating Centre for Frailty, along with the Occitanie Regional Health Agency, to develop the ICOPE MONITOR mobile application.
The ICOPE programme aims to preserve the capacities of the elderly by identifying early signs of frailty and offering solutions to address them. The intention is that by taking charge of their health, all seniors can preserve their independence for longer and delay becoming dependent.
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The ICOPE scheme
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The aim of the ICOPE programme is to enable as many people as possible to age in good health. As a WHO Collaborating Centre for Frailty, Clinical & Geroscience Research, and Geriatric Training, the Gerontopôle of the Toulouse University Hospital has thus implemented the ICOPE programme in the Occitanie Region with the aim of assessing 200,000 seniors within 5 years and promoting healthy ageing by using digital tools.
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The programme aims to prevent loss of autonomy by means of a dedicated application that can monitor and evaluate essential functions of the elderly in a few minutes, in order to better prevent their decline.
Six functions that are essential to maintaining independence and healthy ageing are monitored : mobility, nutrition, vision, hearing, mood and cognition.
This public health programme (aimed at people aged 60 and over) consists in promoting an integrated approach to health that takes into account the person's capacities, corresponding diseases, environment and lifestyle in order to design a care plan specifically for the person in question, that takes into account their wishes and aspirations. The underlying principle is that patients should play a role in their care and follow-up.
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MEDES, technical partner
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As the leading technical instigator for the project, MEDES has developed the following items:

The database, which centralises all the data managed by the project.
Web services allowing the mobile application and the chatbot to query the database (patients of a given professional) and to push the collected data (recorded by a health professional or a patient, assessments of patients) into the database.
The mobile application and chatbot can be used by professionals or patients themselves.
An email notification system to send information about the programme, user accounts, assessment results and reminders to patients about follow-up measures they should take.
A web application, accessible only by health professionals, used for:

collecting patient-assessment data
monitoring patients
administering the system and its users (administrators only)
displaying activity indicators and statistics
exporting data for more in-depth statistics (administrators only)
exporting the list of treatments that can be submitted for billing (administrators only).


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Some figures
(November 2022)
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To find out more
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ICOPE programme presentation brochure
ICOPE MONITOR, an application to prevent functional decline in the elderly - Article CHU Toulouse
The ICOPE programme - Article "Inspire, healthy ageing"
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News
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Our projects
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A question ?
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Our clinical studies
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LBNP - Space Countermeasure
Novel Mobile Lower Body Negative Pressure Device for Orthostatic Training in Microgravity
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In progress
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Countermeasures for the effects of microgravity 
during long crewed spaceflights
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MEDES, Safran Aerosystems, CNES-CADMOS
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CONTEXT
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During crewed spaceflights, when astronauts are exposed to microgravity for a long period, their bodies are subject to many changes such as the headward body fluids shift. 
The objective of the mobile LBNP is to provide a countermeasure against this phenomenon. 
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DESCRIPTION
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Driven by ESA, the newly designed LBNP proposed by the consortium (MEDES/SAFRAN/CNES) is intended to provide a body fluid shift towards the lower parts while the user is performing daily activities and exercises. 
As countermeasure, the LBNP use is intended to prevent:

post flight orthostatic intolerance
cardiovascular deconditioning
occurrence of Spaceflight Associated Neuro-ocular Syndrome (so called SANS)

The prototype is composed of trousers to make negative pressure around the lower parts of the body and a pump powered by a battery.
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MEDES CONTRIBUTION
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Within this project MEDES performs:

the project coordination : MEDES is the main interface with ESA and all partners of the consortium
the state-of-the-art during the early steps of the projects
prepare and execute the validation campaign including the volunteers within the space clinic. 
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PERSPECTIVES
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The prototype should be fully completed during the first semester 2024 after a validation campaign involving volunteers at the space clinic. 
In case of success, new editions of the LBNP could be produced to be used promptly during clinical studies such as bed rests or dry immersions. 
Ultimately, a flight model of the mobile LBNP should be produced to be used by astronauts in space during mission duration. 
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2021
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Ended
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Medical follow-up and physiolophy experiments of the Alpha mission
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ESA, CNES
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In 2016, Thomas Pesquet made his first space flight with the Proxima mission. In the spring of 2021, it will fly again on a new 6-month mission, called Alpha.
More than ten experiments have been developed and supported by CADMOS/CNES, which also manages all the physiological experiments on board the station, whatever the mission and the astronaut who carries them out.
On behalf of CNES, the MEDES team at CADMOS is heavily involved in these specific experiments at Alpha
In addition, MEDES is working closely with the astronaut and will provide medical monitoring for Thomas Pesquet during his flight.
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From preparation on Earth to follow-up in space
On behalf of CNES, the MEDES team at CADMOS is heavily involved in these specific experiments at Alpha : preparation and follow-up with the scientists, spatialization of the experiment, drafting of procedures, training of the astronaut, etc. 
They are now ready for the mission and the teams will then provide operational support for the execution of these experiments on board the ISS.
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Support as close as possible to the astronaut
MEDES provided medical follow-up for Thomas Pesquet during his flight.
This included being present during the preparation phases, during the pre-flight quarantine period, to ensure regular monitoring during the mission, then on landing and during post-flight monitoring.
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MEDES was also involved in the communication phases of the mission: participation in live broadcasts during the spacewalks, Alpha café at the Cité de l'espace, interviews with numerous media to talk about the French experiments, but also about Man in space and its physiological upheavals...
Motivation, expertise, enthusiasm, involvement... a whole team working for the success of this exceptional space adventure !
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News
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Our projects
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A question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/clinique-spatiale-medes/devenir-volontaire/" disabled="on" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]Devenir volontaire ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/space-clinic/clinical-studies/" hover_enabled="0" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}" sticky_enabled="0"]
Our clinical studies
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" disabled="on" global_colors_info="{}"]Urgent ! Recrutement volontaires
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      string(16620) "[et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" background_enable_color="off" background_image="https://www.medes.fr/wp-content/uploads/2022/06/AdobeStock_279577524-compressed-scaled.jpg" custom_padding="40px||40px||true|false" custom_padding_tablet="30px||30px||true|false" custom_padding_phone="30px||30px||false|false" locked="off" global_colors_info="{}" custom_css_after_last_edited="off|desktop"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="|auto|40px|auto|false|false" custom_margin_tablet="||30px||false|false" custom_margin_phone="||30px||false|false" custom_margin_last_edited="on|phone" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.17.4" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_orientation="center" custom_margin="||14px||false|false" custom_padding="||0px|||" header_text_align_tablet="" header_text_align_phone="left" header_text_align_last_edited="on|phone" global_colors_info="{}"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[/et_pb_text][et_pb_divider color="#ffae00" divider_weight="5px" _builder_version="4.18.0" _module_preset="default" width="300px" width_tablet="250px" width_phone="150px" width_last_edited="on|phone" module_alignment="center" custom_margin="||0px||false|false" custom_padding="||2px||false|false" module_alignment_tablet="center" module_alignment_phone="left" module_alignment_last_edited="on|phone" locked="off" global_colors_info="{}"][/et_pb_divider][et_pb_text module_class="projectCategorie" _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_font_size="14px" link_text_color="#444444" text_orientation="center" text_orientation_tablet="center" text_orientation_phone="left" text_orientation_last_edited="on|phone" global_colors_info="{}" link_text_color__hover_enabled="on|hover" link_text_color__hover="#115894"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9jYXRlZ29yaWVzIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJsaW5rX3RvX3Rlcm1fcGFnZSI6Im9uIiwic2VwYXJhdG9yIjoiICIsImNhdGVnb3J5X3R5cGUiOiJwcm9qZWN0X2NhdGVnb3J5In19@[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row use_custom_gutter="on" gutter_width="1" make_equal="on" module_class="rowDetails" _builder_version="4.18.0" _module_preset="default" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}" custom_css_main_element_last_edited="off|phone"][et_pb_blurb title="Date : " use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" admin_label="Résumé" _builder_version="4.19.5" _module_preset="default" header_text_color="#444444" animation="off" global_colors_info="{}"]
2016
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Ended
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Scientific experiments in microgravity
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CNES, MEDES
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Proxima is the name of the mission to be carried out by the astronaut Thomas Pesquet. After his initial selection in 2009, and several long years of training, Thomas will set off on his first mission from Baikonur on 15 November 2016. The mission is scheduled to last 6 months.
He will be the 10th French person to go into space and the 4th to stay on board the International Space Station (ISS). No French astronaut has been on the ISS since Leopold Eyharts in 2008. Thomas Pesquet’s mission is therefore a pretty big event!
 
During his stay on the ISS, he will carry out several scientific experiments. He will contribute to 62 experiments coordinated by the ESA and CNES, as well as to 55 other experiments for the American, Canadian and Japanese space agencies. Thomas will therefore have a busy schedule on top of his daily sports sessions, meals, moments of relaxation, sleep, etc.
The experiments carried out on behalf of the European scientific community aim to improve our understanding of the human body, biology and physics, and test new technologies on board the ISS.
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MEDES and Proxima
 
MEDES is participating in the Proxima mission through its collaboration with CADMOS (the French centre for the development of microgravity applications and space operations) concerning the physiological aspects of the experiment, and with the European Astronaut Centre (EAC) in Cologne, as regards the monitoring of astronaut training and medical support.
In addition to a MEDES team seconded to CADMOS, MEDES directly contributed to preparing some of the seven experiments prepared and supervised by CNES.
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Focus on experiments carried out with MEDES support
The Everwear software monitors physiological, medical and nutritional parameters of the astronauts on board the ISS. Coupled to an array of biomeical sensors, the application will act somehow as a medical assistant to the astronaut.
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The Aquapad device aims to analyse water on the ISS in a new way. Utilizing a groundbreaking technology, the analysis will be provided in a significantly faster and simpler manner without loss of performance.
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Scientists are working on new intelligent surfaces that prevent the bacteria from landing, proliferating and creating biofilms. The objectives for Matiss is to test the efficiency of these surfaces.
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News
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Our projects
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A question ?
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Our clinical studies
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2021
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Study of the effects of space flight on the human body
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ESA
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The “Medium duration Nutrition and vibration eXercise” (MNX) study was part of a research programme being conducted under the leadership of the French and European space agencies.
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Its main aim was to study the effectiveness of two methods for mitigating the effects of microgravity to which astronauts are subjected (countermeasures):

exercising the lower limbs ("squats") under resistance, on a vibrating platform. This exercise was conducted twice a week,
the same physical exercise programme combined with protein and potassium bicarbonate supplementation in the daily diet.

Twelve volunteers were recruited for this study. They underwent three periods of hospitalisation each lasting 35 days (including 21 days of bed rest each time). Each period was separated from the next by a period of 4 months, making the total study duration 1 year.
Nine teams of scientists took part in the study.
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Key figures for the study
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Implementation of the study
The 12 study volunteers were divided into three groups as follows:

Exercise and vibration group: during the bed-rest period, the volunteers from this group underwent physical training twice a week ("squat" type exercises, i.e. pushing with their legs) lying down on a vibrating platform on a machine specially designed for this purpose.
Exercise and vibration plus nutrition group: during the bed-rest period, the volunteers in this group underwent the same physical training as the previous group, but received a slightly different daily diet: the amount of protein was increased with additional intake in the form of whey protein and potassium bicarbonate. This supplementation was administered with main meals and snacks (6 times/day).
Control group: this group served as a control for the experiment. The subjects in this group did not do exercise sessions on the vibrating platform and followed a standard controlled diet. By comparison, this group served to assess the effect of the two types of countermeasures on each volunteer.

This was a cross-over study, meaning that each of the 12 volunteers acted as their own control, and changed group each period. Lots were drawn to determine the order in which they changed between the three groups.

Each hospitalisation period of 35 days was broken down into three phases:

An ambulatory control period of 7 days before bed rest,
Anti-orthostatic bed rest (inclined at -6°) for a period of 21 days,
An ambulatory recovery period of 7 days after bed rest.


Following each hospitalisation period, the volunteers returned for follow-up visits, 14 days and 28 days after the end of each bed-rest campaig
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Les protocoles scientifiques
Nine research teams studied the mechanisms of the body’s adaptation to 21 days of simulated microgravity and the effect of the two countermeasure protocols on the following physiological systems :
 

Metabolic systems



The cardiovascular system and its control mechanisms



The osteoarticular system and muscles



The bloodstream, primarily the mechanisms of blood coagulation

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The main lead scientists who participated in this study are as follows:
[/et_pb_text][et_pb_image src="https://www.medes.fr/wp-content/uploads/2022/11/1-1.png" title_text="1" _builder_version="4.19.1" _module_preset="default" custom_margin="0px||||false|false" custom_padding="||||false|false" global_colors_info="{}"][/et_pb_image][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.20.2" _module_preset="default" custom_padding="60px||60px||true|false" custom_padding_tablet="40px||40px||true|false" custom_padding_phone="30px||30px||true|false" locked="off" global_colors_info="{}"][et_pb_row column_structure="3_5,2_5" use_custom_gutter="on" make_equal="on" custom_padding_last_edited="on|phone" _builder_version="4.20.2" _module_preset="default" width="95.3%" width_tablet="95.3%" width_phone="80%" width_last_edited="on|phone" custom_margin="|auto|27px|auto||" custom_margin_tablet="|auto|27px|auto||" custom_margin_phone="0px||0px||true|true" custom_margin_last_edited="on|phone" custom_padding="0px||0px|34px|true|false" custom_padding_tablet="0px||0px|34px|true|false" custom_padding_phone="|0px||0px|true|true" global_colors_info="{}"][et_pb_column type="3_5" _builder_version="4.20.2" _module_preset="default" global_colors_info="{}" custom_css_main_element_last_edited="on|tablet" custom_css_main_element_tablet="margin-bottom: 30px !important;" custom_css_main_element_phone="margin-bottom: 30px !important;"][et_pb_text admin_label="Pourquoi une immersion sèche ?" _builder_version="4.21.0" header_2_text_align="right" background_size="initial" background_position="top_left" background_repeat="repeat" text_orientation="right" width="94.6%" custom_margin="|-112px||-30px|false|false" custom_margin_tablet="|-107px||-44px|false|false" custom_margin_phone="|0px||0px|false|true" custom_margin_last_edited="on|phone" custom_padding="0px||||false|false" hover_enabled="0" header_2_text_align_tablet="left" header_2_text_align_phone="left" header_2_text_align_last_edited="on|tablet" text_orientation_tablet="left" text_orientation_phone="left" text_orientation_last_edited="on|tablet" locked="off" global_colors_info="{}" sticky_enabled="0"]
Nutrition during the study
Food and everything that relates to it (health, social interaction, etc.) is essential for astronauts on long-duration missions.
During a long-duration mission, eating right is vital for theastronauts. It’s fuel for their bodies, but meal times together are also good for morale. In microgravity, the energy balance is negative. Astronauts lose weight, either because they don’t eat enough or because they do a lot of exercise. In the long term, their performance could be affected and mission success compromised. When preparing a journey to Mars, food is both a health and logistics issue. Taking the wrong amount would be critical for the crew’s health and the cost of the mission", explains Marie-Pierre Bareille, head of the bedrest programme at MEDES (Source: excerpt from the article “What’s on the menu?”, Cnes Mag n°58).
The European Space Agency (ESA) has therefore defined a long-term strategy to standardise the conditions of bed-rest studies especially with regard to nutrition (Working Group on Space Nutrition of the European Space Agency: Ms M. Heer, Mr S. Blanc and Dr. G. Biolo).
During these experiments, nutritional intakes are now fully monitored and controlled.
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Nos actualités
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Nos projets
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(12859) "[et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" background_enable_color="off" background_image="https://www.medes.fr/wp-content/uploads/2022/06/AdobeStock_279577524-compressed-scaled.jpg" custom_padding="40px||40px||true|false" custom_padding_tablet="30px||30px||true|false" custom_padding_phone="30px||30px||false|false" locked="off" global_colors_info="{}" custom_css_after_last_edited="off|desktop"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="|auto|40px|auto|false|false" custom_margin_tablet="||30px||false|false" custom_margin_phone="||30px||false|false" custom_margin_last_edited="on|phone" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.17.4" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_orientation="center" custom_margin="||14px||false|false" custom_padding="||0px|||" header_text_align_tablet="" header_text_align_phone="left" header_text_align_last_edited="on|phone" global_colors_info="{}"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[/et_pb_text][et_pb_divider color="#ffae00" divider_weight="5px" _builder_version="4.18.0" _module_preset="default" width="300px" width_tablet="250px" width_phone="150px" width_last_edited="on|phone" module_alignment="center" custom_margin="||0px||false|false" custom_padding="||2px||false|false" module_alignment_tablet="center" module_alignment_phone="left" module_alignment_last_edited="on|phone" locked="off" global_colors_info="{}"][/et_pb_divider][et_pb_text module_class="projectCategorie" _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_font_size="14px" link_text_color="#444444" text_orientation="center" text_orientation_tablet="center" text_orientation_phone="left" text_orientation_last_edited="on|phone" global_colors_info="{}" link_text_color__hover_enabled="on|hover" link_text_color__hover="#115894"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9jYXRlZ29yaWVzIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJsaW5rX3RvX3Rlcm1fcGFnZSI6Im9uIiwic2VwYXJhdG9yIjoiICIsImNhdGVnb3J5X3R5cGUiOiJwcm9qZWN0X2NhdGVnb3J5In19@[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row use_custom_gutter="on" gutter_width="1" make_equal="on" module_class="rowDetails" _builder_version="4.18.0" _module_preset="default" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}" custom_css_main_element_last_edited="off|phone"][et_pb_blurb title="Date : " use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.5" _module_preset="default" header_text_color="#444444" animation="off" global_colors_info="{}"]
2013
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Study of cardiovascular regulation mechanisms in the standing position and the effects of plantar mechanical stimulation
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MEDES conducted a clinical study called Orthoboots with 12 male volunteers, between January and March 2013.
The main objectives of the study were to:

investigate the mechanisms of cardiovascular regulation in the standing position (orthostatism) in order to improve health care for patients suffering frequent fainting fits, and
evaluate the effects of plantar mechanical stimulation on the response of the cardiovascular system to the transition to the standing position (carried out with the "Korvit" plantar stimulation shoes).

Concomitantly with this protocol, a new therapeutic strategy for treating motor disorders was also tested, applicable in venous pathologies and as a preventive measure for disorders induced by space travel.
 
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Equipment used
 
Lying on a tilt table (a kind of bed that can be raised mechanically), the subject was also equipped with plantar stimulation shoes and various sensors to measure the following parameter. s:

Blood pressure,
The electrical activity of the heart (electrocardiogram – ECG)
Respiratory rate,
Skin blood flow,
An ultrasound assessment of a leg vein behind the knee.

 
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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      string(0) ""
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      ["menu_order"]=>
      int(0)
      ["post_type"]=>
      string(7) "project"
      ["post_mime_type"]=>
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      ["comment_count"]=>
      string(1) "0"
      ["filter"]=>
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      ["ID"]=>
      int(13248)
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      string(1) "1"
      ["post_date"]=>
      string(19) "2018-12-01 10:53:24"
      ["post_date_gmt"]=>
      string(19) "2018-12-01 09:53:24"
      ["post_content"]=>
      string(20345) "[et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" background_enable_color="off" background_image="https://www.medes.fr/wp-content/uploads/2022/06/AdobeStock_279577524-compressed-scaled.jpg" custom_padding="40px||40px||true|false" custom_padding_tablet="30px||30px||true|false" custom_padding_phone="30px||30px||false|false" locked="off" global_colors_info="{}" custom_css_after_last_edited="off|desktop"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="|auto|40px|auto|false|false" custom_margin_tablet="||30px||false|false" custom_margin_phone="||30px||false|false" custom_margin_last_edited="on|phone" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.17.4" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_orientation="center" custom_margin="||14px||false|false" custom_padding="||0px|||" header_text_align_tablet="" header_text_align_phone="left" header_text_align_last_edited="on|phone" global_colors_info="{}"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[/et_pb_text][et_pb_divider color="#ffae00" divider_weight="5px" _builder_version="4.18.0" _module_preset="default" width="300px" width_tablet="250px" width_phone="150px" width_last_edited="on|phone" module_alignment="center" custom_margin="||0px||false|false" custom_padding="||2px||false|false" module_alignment_tablet="center" module_alignment_phone="left" module_alignment_last_edited="on|phone" locked="off" global_colors_info="{}"][/et_pb_divider][et_pb_text module_class="projectCategorie" _builder_version="4.18.0" _dynamic_attributes="content" _module_preset="default" text_font_size="14px" link_text_color="#444444" text_orientation="center" text_orientation_tablet="center" text_orientation_phone="left" text_orientation_last_edited="on|phone" global_colors_info="{}" link_text_color__hover_enabled="on|hover" link_text_color__hover="#115894"]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9jYXRlZ29yaWVzIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJsaW5rX3RvX3Rlcm1fcGFnZSI6Im9uIiwic2VwYXJhdG9yIjoiICIsImNhdGVnb3J5X3R5cGUiOiJwcm9qZWN0X2NhdGVnb3J5In19@[/et_pb_text][/et_pb_column][/et_pb_row][et_pb_row use_custom_gutter="on" gutter_width="1" make_equal="on" module_class="rowDetails" _builder_version="4.18.0" _module_preset="default" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}" custom_css_main_element_last_edited="off|phone"][et_pb_blurb title="Date : " use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" global_colors_info="{}"]
2014-2018
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Preventing health crises at transport hubs
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MEDES, APHP, public Health England,
University of Eastern Finland, VTT Finnish Institute
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Prevention and management of high-risk pathogens in transport hubs
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The project aimed to develop tools and recommendations to help manage health crises in transport hubs (airports, ports and railway stations).
The aim is to help transport operators and stakeholders in major transport hubs to develop their preparedness and response plans to deal with pandemics and dangerous pathogens.
The project was funded by the European Commission (FP7 Framework Programme, Security Theme SEC-2013.2.2-2). It ran from 2014 to 2018.
The project adopted a proactive approach to pathogen prevention.
As a starting point, Pandhub began identifying "hotspots" that have a higher risk of transmitting germs via breathing, sneezing and touching. The project identified these areas by studying potential infection transmission routes, passenger flows, and the unique characteristics of busy transport areas.
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Project partners
Partners in the project included APHP (SAMU de Paris), MEDES-IMPS (Institute of Space Medicine and Physiology), the English Department of Health (Public Health England), the University of Nottingham (Health Protection and Influenza Research Group), and the University of Eastern Finland. It was coordinated by the Finnish VTT Institute.
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Contribution from MEDES

MEDES contributed to the project by developing the PANDHUB system, a solution for configuring and obtaining highly flexible data collection tools.
In the context of the project, the system is used to support epidemiological investigations, contact tracing and outbreak management.
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For more information
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The solution developed for the project led to construction of the DATAMIA data collection platform.
Indeed, in addition to the contexts of use targeted by the PANDHUB project, the system can be used in many other contexts, whenever there is a need to organise data collection campaigns, such as clinical research, occupational medicine, crisis management, etc.
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Nos actualités
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/our-projects/" global_colors_info="{}"]
Nos projets
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Une question ?
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Devenir volontaire ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.19.5" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/space-clinic/clinical-studies/" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}"]
Nos études cliniques
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/a-la-une/recrutement/" global_colors_info="{}"]
Urgent ! Recrutement volontaires
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2011
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Ended
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Study on the effectiveness of drugs during sleep deprivation
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This study was part of the European PharmaCog project, which marked the beginning of an ambitious public-private partnership to advance pharmaceutical research for the treatment of Alzheimer's disease.
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Context
Alzheimer's disease is a progressive brain disorder that leads to a gradual and irreversible decline in memory and cognitive functions. At present, the drugs available to treat it are not very effective, hence the need to develop new products that act on the symptoms.
Scientists are focusing on the development of cognitive/memory criteria/markers used in a number of experimental models that artificially induce transient Alzheimer-like disorders.
The use of total sleep deprivation is a good candidate as a physiological model. Various total sleep deprivation studies have been conducted in healthy volunteers for periods ranging from 24 to 72 hours. The 24-hour sleep deprivation model seems to be the best candidate.
The project lasted six years (2010-2015). MEDES was involved in a clinical study at the beginning of the project.
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Objectives
The main objectives of the project were to:

Assess whether sleep deprivation is a possible model for cognitive disorders by evaluating whether drugs are able to alleviate these disorders.
Test the recovery effects of a single dose of modafinil, and also the effects of donepezil and memantine on cognitive function in young, healthy, sleep-deprived subjects.

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Study configuration
The study was carried out on 12 male volunteers aged between 25 and 40 years. They were successively hospitalised five times, each for a period of 48 hours.

Part A: periods 1 and 2 at intervals of seven days. (D-1, arrival at the clinic at 4pm, medical examination, positioning of electrodes, blood test – D1: sleep deprivation: modafinil intake)
Part B: three hospitalisations of 48 hours each, separated by a period of six weeks with medication for 13 days before arrival at the Clinic. Intake of Motilium for 15 days to avoid digestive problems.

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More information
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The PharmaCog project, on the IMI (Innovative Medicines Initiatives) website
Final project report (2015)
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2019-2021
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Development of an application to improve monitoring of chronic illnesses in children
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MEDES, RéPPOP
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TiChroN aims to comprehensively address the problems identified in the monitoring, treatment and autonomy of children with chronic diseases, based on ICT and involving the sectors of society that regularly interact with these children.

The project provides children, families and caregivers with optimized tools for care and early action in case of the appearance of anomalies in their health status.




Project objectives
The innovative nature of the project is reflected in the different activities proposed, which place the patient at the center of the project:

Analysis of the specific needs of the children and the actors surrounding them
Design of ergonomic and interactive ICT tools dedicated to the target population (children, adolescents), used to technologies
Creation of common and optimized protocols and training for all stakeholders involved
Pilot study of the tools and test protocols in the 3 countries
Analysis of results to define best practices

TiChroN aims to globally solve the problems identified in the monitoring, treatment and training of children with chronic diseases, based on ICT and involving sectors of society that regularly interact with these children.
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Expected results

New e-health benefits and services
Improved qualification of healthcare professionals through the exchange of international best practice
Cost and organisational savings through reduced errors
Consolidation of international networks for the incorporation of e-health
Development of the business network in the ICT sector, increasing competitiveness and economic activity in the SUDOE regions
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Involvement of MEDES
MEDES has taken part in the development of tools to help monitor children with chronic illnesses, and in particular has developed 2 applications :

Mobile application for children
This application is used to set up standard conversations designed by the project's partner medical teams. It enables them to :

 



Plan and evaluate physical exercise
Assess the quantity and quality of sleep
Assess the child's blood sugar monitoring
Assess children's asthma monitoring


Web application for medical teams
Designed for medical teams, the werb application makes it possible to :


Include the child in the monitoring programme
Consult and export data entered by the child via the chatbot


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The partnership
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Main partners :

    The Health Service of Cantabria
    The Center for Information and Communication Technologies (CTIC)
    Future Balloons
    The University of Minho
    MEDES
    ACCOMIP-RéPPOP (Association for the Concerted Management of Obesity in the Midi-Pyrenees - Network for the Prevention and Management of Pediatric Obesity in the Midi-Pyrenees)

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Associated partners :

    Federación Cántabra de Personas con Discapacidad Física y Orgánica
    Telefonica España S.A.U
    Consejería de Educación, Cultura y centros educativos, Red de escuelas promotoras de salud
    creSco - Paul Sabatier University, Toulouse
    University Hospital Center of Toulouse
    University Hospital Center of Coimbra
    Childhood Adolescence and Diabetes - C. H.U of Toulouse
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The Tichron project is carried out thanks to the co-financing of the European Union and the SUDOE territorial cooperation program.


To learn more about the project : https://www.tichron.eu
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News
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Our projects
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="u||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="#5e5e5e" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/contact/" hover_enabled="0" global_colors_info="{}" sticky_enabled="0"]
A question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/clinique-spatiale-medes/devenir-volontaire/" disabled="on" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]Devenir volontaire ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.21.0" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/en/space-clinic/clinical-studies/" hover_enabled="0" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}" sticky_enabled="0"]
Our clinical studies
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" disabled_on="on|on|on" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="/a-la-une/recrutement/" disabled="on" global_colors_info="{}"]Urgent ! Recrutement volontaires
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Etude de l'efficacité d'un pantalon thermorégulateur chez des femmes présentant une insuffisance veineuse légère.
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2007
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Terminé
[/et_pb_blurb][et_pb_blurb title="Objectif : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Etude de l'efficacité d'un tissu intelligent
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AVELANA, KLIMEO, MEDES
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But de l'étude
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De nombreux sujets et essentiellement des femmes souffrent d’insuffisance veineuse.  Les manifestations cliniques sont très variables et souvent négligées par le patient et son médecin.
Les symptomes sont majorés en période estivale avec l’accroissement des températures.
L’entreprise AVELANA, fabriquant des textiles féminins a mis au point un nouveau tissu thermorégulateur appelé KLIMEO. Grace à ses caractéristiques thermorégulatrices, ce tissu permet de diminuer la sensation de froid ou de chaud lorsque l’on passe dans un environnement thermique différent.
L'étude a été réalisée à la clinique MEDES entre juillet et août 2007.
Le but principal de cette étude a été de comparer l’efficacité sur le plan thermique du pantalon thermorégulateur KLIMEO par rapport à un pantalon neutre (placebo) et d’évaluer le confort global et l’évolution de l’insuffisance veineuse de sujets féminins présentant une insuffisance veineuse légère.
L’effet du tissu thermorégulateur KLIMEO a été évalué sur les membres inférieurs de sujets présentant une insuffisance veineuse modérée.
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Le Pantalon KLIMEO utilisé pour l'étude
Le tissu KLIMEO appartient à la gamme de « tissus intelligents » et possède des propriétés thermorégulatrices.
Sur les fibres du tissu sont greffées des microcapsules, invisibles à l’œil nu, contenant un actif naturel de thermorégulation. Ce produit actif de thermorégulation change de phase en fonction de la température extérieure. Ainsi dans un environnement froid, les microcapsules passent en phase solide en restituant de la chaleur et limitent donc la baisse de température, donnant ainsi une sensation de chaud sur la peau.
A l’inverse dans un environnement chaud, les microcapsules passent en phase liquide en absorbant de la chaleur et limitent donc la montée en température, donnant donc une sensation de frais sur la peau.
Ces changements de phases sont totalement transparant pour l’utilisateur et l’avantage de cette technique de greffage permet la succession respectives des phases dès le changement de température.
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Objectif de l'étude
 
L’objectif principal de l’étude était de mesurer la température cutanée et de suivre son évolution dans des ambiances thermiques standardisées et de les comparer selon le type de pantalon (KLIMEO ou neutre).
Les objectifs secondaires ont été d’évaluer l’efficacité du pantalon thermorégulateur sur le confort global du sujet (stress...) et sur l’insuffisance veineuse légère.
 
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Déroulement de l'étude

Vingt personnes ont participé à cet essai.
La participation a compris :

Une visite de sélection réalisée dans les 28 jours précédant l’évaluation du pantalon,
Deux visites d’évaluation correspondant à l’évaluation de paramètres physiologiques permettant d’apprécier le rôle thermorégulateur du pantalon (par mesure thermique), le rôle sur le confort physiologique (paramètres cardio-respiratoire) et veineux (questionnaire d’appréciation). La première visite a permis d'évaluer le premier pantalon et la deuxième visite a permis d'évaluer celui qui n’avait pas été testé la première fois.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2021
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Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Study of the effects of space flight on the human body
[/et_pb_blurb][et_pb_blurb title="Partner :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
ESA
[/et_pb_blurb][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.18.0" _module_preset="default" custom_padding="60px||60px||true|false" custom_padding_tablet="40px||40px||true|false" custom_padding_phone="30px||30px||true|false" global_colors_info="{}"][et_pb_row _builder_version="4.18.0" _module_preset="default" custom_margin="||10px||false|false" custom_padding="0px||0px||true|false" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.18.0" _module_preset="default" global_colors_info="{}"][et_pb_text admin_label="MEDES a mené pour l'ESA" _builder_version="4.21.0" background_size="initial" background_position="top_left" background_repeat="repeat" locked="off" global_colors_info="{}"]
Cultivating our differences and drawing on our resources to create wealth...
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Spagyria is a cross-border cooperation project which, through a network of specialised employment centres and research centres, aims to extend the growing of aromatic plants and their processing in the laboratory, as well as research into innovative processes through fully sustainable technologies for the development of natural cosmetic products.
This 4-year project (2018 – 2021) was co-financed by the European Regional Development Fund (ERDF).
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In detail…
Spagyria is :

A project that aimed to create a new production line for plant extracts for the production of environmentally-friendly cosmetics.
A solidarity project involving people with disabilities or integration difficulties, which will help to improve their employability and thus their quality of life.
A future ecological certification label (bio-handicap)
The capitalisation of experience and the economic development of the partners on each side of the border, both in terms of the growing and packaging of aromatic plants and for the extraction, manufacturing and testing processes.

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MEDES’s role in the project
MEDES was involved in this project during the project design phase and then during a second phase for the practical implementation of the clinical study, once the phases for development and research into the active ingredients of cosmetics have been completed by the processing and treatment centres.
The clinical study took place at the end of 2021.
 
 
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 Les partenaires du projet
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Plus d'informations sur le projet ?
https://www.spagyria-fres.eu/fr/
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Nos actualités
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#D6D6D6" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/our-projects/" global_colors_info="{}"]
Nos projets
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="u||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#5e5e5e" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/contact/" global_colors_info="{}"]
Une question ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/space-clinic/become-a-volunteer/" global_colors_info="{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}"]
Devenir volontaire ?
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="||fa||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="30px" module_class="boutonFixe" _builder_version="4.19.5" _module_preset="default" background_color="gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/en/space-clinic/clinical-studies/" global_colors_info="{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}"]
Nos études cliniques
[/et_pb_blurb][et_pb_blurb use_icon="on" font_icon="s||divi||400" icon_color="#FFFFFF" icon_placement="left" image_icon_width="28px" module_class="boutonFixe" _builder_version="4.20.2" _module_preset="default" background_color="#002130" custom_padding="10px|10px|10px|10px|true|true" animation="off" link_option_url="https://www.medes.fr/a-la-une/recrutement/" global_colors_info="{}"]
Urgent ! Recrutement volontaires
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2013-2014
[/et_pb_blurb][et_pb_blurb title="State of progress :" use_icon="on" font_icon="||fa||400" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Ended
[/et_pb_blurb][et_pb_blurb title="Objective : " use_icon="on" font_icon="||fa||900" icon_color="#115894" icon_placement="left" image_icon_width="30px" image_icon_width_tablet="28px" image_icon_width_phone="25px" image_icon_width_last_edited="on|phone" _builder_version="4.21.0" _module_preset="default" header_text_color="#444444" animation="off" locked="off" global_colors_info="{}"]
Developing innovative technologies
for personalised medicine
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MEDES, ITA, CHU Toulouse
Univ Lisbonne, CETEMMSA, CONETIC
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Projet description 
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Our lifestyles are changing. These changes generally have a direct impact on our health.
TEMIS offers effective solutions to measure and assess them thanks to the use of simple technology. The solutions generate health indicators making it possible to provide a more personal form of medicine to each individual.
The TEMIS project (21 months) is produced thanks to co-financing from the European Union and the ERDF in addition to the SUDOE territorial cooperation programme.
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TEMIS technologies
TEMIS proposes developing such technologies, testing them on healthy subjects and patients while also ensuring their transfer to industrial companies and service providers.

The proposed technologies may be used either in combination with one another or separately in order to tackle various medical conditions or illnesses. The proposed innovation is both medical and technical. The technologies proposed by TEMIS aim to make it possible to quantify and qualify physical activity or describe the movement of person's limbs. These technologies also combine the data processing necessary to define useful indicators both for the person and the doctor, in addition to the software platform to manage the data exchanged and to supply relevant indicators for the various possible users.

The R&D will be particularly targeting:

An application using a Kinect sensor (a sensor associated with the Xbox gaming console) to describe the movements of the body's limbs for neurological diseases.
A lighter solution to measure physical activity while on the move using a smartphone, possibly combined with an "smart clothe" supplying vital signs (breathing, heart rhythm, skin temperature, etc.)
And finally, a software platform managing the exchange and processing of data and supplying associated services.

 
These technologies will be evaluated with populations having varying levels of physical activity: 40 healthy young people, 20 obese subjects, 40 elderly people and 30 Parkinson's patients, with subjects being recruited both in Portugal and in France.
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The TEMIS project is based on the definition of simple, innovative, yet inexpensive and accessible technologies to quantify and qualify a person's lifestyle, in order to provide health indicators that can then be used for more personalised medicine.
TEMIS, through the involvement of 6 partners, proposed to develop such technologies, to test them on healthy subjects and patients, while ensuring the transfer to manufacturers and service providers.
 
A video presenting the project is attached.
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Technological innovations
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Partnership
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The TEMIS project met the requirements of the SUDOE programme and corresponded to a joint R&D initiative that integrates different regions and Community projects into networks and/or strengthens the investigation-innovation system, improving the international position of the regions in areas of common interest.
Six European partners were involved in this project, representing three cross-border countries: France, Spain and Portugal.
 
The partnership in detail :


MEDES - Institut de Médecine et de Physiologie Spatiales (Institute of Space Medicine and Physiology): lead partner, development of smartphone applications and integration of the software platform
Instituto Tecnológico de Aragón Area Operaciones Division Tecnologicas Multimedia (ITA): development of the Kinect application
Centre Hospitalier Universitaire de Toulouse (CHUT): medical specifications, evaluations on healthy subjects and patients.
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina Universidade de Lisboa / Faculdade de Medina: medical specifications and evaluation on healthy subjects and patients.
Fundació CETEMMSA: development of the intelligent clothing sub-system
Confederacion Española de Tecnologias de la Informacion Comunicaciones y Electronica (CONETIC): co-ordination of the co-operation network, promotion to industry.
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More information
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TEMIS User Guide
SUDOE website
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News
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Our projects
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A question ?
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Our clinical studies
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2008
2010
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Ended
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Study of drug intake on alertness (in simulated driving)
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Assistance publique des hopitaux de Marseille, 
MEDES
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MEDES carried out two studies, in 2007-2008 and then in 2010, on the effects of taking a therapeutic drug referred to as "Medico-Médicament" and then cannabis, referred to as "Medico-Cannabis", on driving performance and behaviour.
For this purpose, driving performance was assessed and compared in two ways : 

First, under experimental conditions on a simulator reproducing car driving,
Then under actual driving conditions on a motorway stretch.

Driving under simulated conditions was tested in the Space Clinic, which is equipped with a simulator that reproduces car driving. Real-life driving was tested on a stretch of motorway in Bordeaux.
The study sponsor was the Marseille public hospital system. MEDES coordinated its implementation for the "simulated driving" part.
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Objectives of the studies

“Médico-Médicaments” (2007-2008)
 The aim of this study was to evaluate the effects of a single dose of a drug from the benzodiazepine class (with a high sleep-inducing potential) on the ability of healthy subjects to drive under simulated and real conditions.
“Médico-Cannabis” (2010)
The aim of this study was to provide an accurate and objective description of the effects of cannabis use on driving performance and behaviour. Indeed, the behavioural effects of cannabis, in particular drowsiness and sluggish behaviour, have prompted studies of their impact on driving.
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Study configuration
During the simulated drive, volunteers were seated in a cockpit and presented with a visual scene projected on a screen. They were asked to drive in the centre of the right-hand lane unless overtaking, and to maintain a constant speed. During the trip, various driving parameters were measured (speed variation, line crossing, lateral deviation).
During the actual driving, the volunteer drove a vehicle and was accompanied throughout the journey by an experienced co-driver and staff authorised to take blood samples. The driving took place on a section of motorway (Langon-Agen route). The trip was recorded using a camera set up in the car and the driving parameters were then analysed.
Each subject took part in four sessions:

two sessions that took place at MEDES (Toulouse Rangueil University Hospital) with an interval of about one week between them,
two actual driving sessions, also one week apart, which took place on a stretch of motorway in Bordeaux.

In each case, one of the two sessions was conducted with the use of medication or cannabis, and the other without any intake. Neither the volunteer nor the scientists knew whether or not there had been intake of a drug or cannabis in a session.
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Expected benefits of these studies
The aim of this research was to better assess the actual impact of benzodiazepine and cannabis use on driving and to improve the methods of investigation for testing these substances for health and road safety purposes.
In the longer term, these experimental procedures might be proposed for routine testing of any compound which might have a negative effect on driving.
The ultimate goal of this research is to improve road safety and reduce the risk of traffic accidents related to the use of "pharmacologically" active substances, and thus hopefully contribute to the reduction of human and financial costs due to accidents.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2016
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Ended
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Dry immersion study and Physical countermeasure study (Wecare device)
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ESA, CNES, Quinetic Space
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MEDES conducted a study on behalf of ESA to test a new countermeasure (preventive method) to ensure the health of astronauts: the WECARE device. The device was tested in the context of a study simulating weightlessness, using the dry immersion model, which had recently been installed in the Space Clinic premises (first study carried out in 2015).
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The device was designed by Qinetic Space and MEDES under an ESA contract.
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For this study, the dry immersion weightlessness simulation model was used. The volunteer is "immersed" for three days in a kind of bathtub and is isolated from the water by a waterproof sheet.
 
This position simulates the effects that an astronaut may experience during space flight and reproduces many of the negative effects imposed by weightlessness on the body.
 
The WECARE device is a countermeasure (preventive method) to prevent and limit these negative effects. It combines physical exercise on a horizontal leg press, which causes the whole body to vibrate and enables proprioceptive training of the ankles.
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Objectives of the study
Designed for ESA with the support of CNES, the device aims to combat bone demineralisation and muscle wasting in astronauts during space flight and to maintain their proprioceptive capacities.
The device is designed as a set of two active pedals that act as support platforms for the arches of the subject's feet.
It allows two types of mechanical stress to be applied:

Vibrations to combat bone demineralisation,
Rotational movements in the arches of the feet while the subject performs knee flexion-extension exercises. This stress aims to maintain the subjects’ proprioceptive capacities and their ability to stand upright and keep their balance after the simulation.

The volunteers use the device for 45 minutes a day in a supine position. Six volunteers took part in the study, which ended on Friday 1 July. 
The results will help to establish the usefulness of this type of prevention and its possible future implementation.
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More information...
[/et_pb_text][et_pb_text admin_label="Pourquoi une immersion sèche ?" _builder_version="4.21.0" header_2_text_align="right" background_size="initial" background_position="top_left" background_repeat="repeat" text_orientation="right" custom_padding="|18px||0px|false|false" header_2_text_align_tablet="left" header_2_text_align_phone="left" header_2_text_align_last_edited="on|tablet" text_orientation_tablet="left" text_orientation_phone="left" text_orientation_last_edited="on|tablet" border_color_all="#256c9e" border_width_right="7px" locked="off" global_colors_info="{}"]
Why simulate the effects of weightlessness on the ground?
Experiments simulating the effects of weightlessness are carried out on the ground to gain a better understanding of the mechanisms by which the human body adapts to weightlessness, to prepare for space flights and to develop means of preventing (known as countermeasures) the negative effects of weightlessness.
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What is the dry immersion model?
This model, developed and used by Russian scientists, was used for the first time by MEDES on 12 healthy subjects at the beginning of 2015.
This 'dry immersion' model is interesting because it induces physiological effects that cannot be faithfully reproduced by the other simulation model more widely used to date, the 'bed rest' model, and 'dry immersion' therefore complements it.
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Nos projets
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2005
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Ended
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Study of the effects of space flight on the human body and Nutritional and exercise countermeasures
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CNES, ESA, NASA, CSA
[/et_pb_blurb][/et_pb_column][/et_pb_row][/et_pb_section][et_pb_section fb_built="1" custom_padding_last_edited="on|phone" _builder_version="4.19.1" _module_preset="default" background_enable_image="off" background_size="custom" background_image_width="16%" background_image_height="0%" background_position="top_left" background_horizontal_offset="0%" background_vertical_offset="32%" custom_padding="60px||60px||true|false" custom_padding_tablet="40px||40px||true|false" custom_padding_phone="30px||30px||true|false" global_colors_info="{}"][et_pb_row _builder_version="4.19.1" _module_preset="default" global_colors_info="{}"][et_pb_column type="4_4" _builder_version="4.19.1" _module_preset="default" global_colors_info="{}"][et_pb_text _builder_version="4.19.1" _module_preset="default" global_colors_info="{}"]
The WISE (Women International Space Simulation for Exploration) study, conducted in 2005-2006, was a bed rest study of 24 female volunteers who stayed 100 days at the Toulouse Space Clinic, 60 of which were spent lying down to simulate the effects of weightlessness.
 
The study took place in two sessions: from April to June 2005 for the first 12 volunteers, and from September to December for the other 12.
This bed rest study was organised by MEDES for the French, European, American and Canadian Space Agencies (CNES, ESA, NASA and CSA).
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An essential study to advance research
 
As space flight is not a common occurrence, ground-based studies are essential to prepare for long-duration crewed flights.
Twenty-four female volunteers took part in this study for 100 days, staying for 60 days with their bodies slightly tilted downwards (-6°) to simulate the physiological effects of a prolonged stay in weightlessness.
MEDES regularly conducts bed rest experiments but this was the first long-term experiment with female volunteers.
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The aim of the experiment was to investigate the extent to which diet and exercise can counteract the adverse effects of the prolonged absence of gravity, simulated by these bed rest conditions.
The volunteers who took part in the study came from France, Great Britain, Germany, Finland and the Netherlands, but also from Poland and the Czech Republic, a sign of the considerable interest in the WISE study among the new Member States of the European Union.
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Objectives of the study
The aims of the study were to assess the consequences of a long, simulated flight and to test the effectiveness of the countermeasures used.
Internationally renowned scientific teams followed protocols to monitor the following :

Physical capacity,
Heart function and blood circulation,
Blood measurements,
Muscle structure and function, Bone structure and function,
Energy and nutritional requirements,
Immune system,
Hormonal regulation and the reproductive cycle,
Reflexes and balance,
Mood and well-being.

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Study configuration
 
The WISE study was carried out in two successive campaigns, each involving 12 volunteers.
The volunteers were randomly divided into three groups:

One group served as a control group and received no countermeasures.
One group performed a combination of physical exercises while remaining in bed.
The third group received a nutritional supplement.

The results are intended to be compared with those obtained by astronauts during space flights.
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The study lasted 101 days, of which 60 days were spent in the supine position, broken down as follows :

The first phase of the study consisted of volunteers undergoing a series of tests to collect basic physiological data to serve as a reference throughout the study.
At the end of this 20-day preliminary observation phase, the actual bed rest phase took place. During this phase the volunteers were subjected to a series of examinations and tests according to the various study protocols. During this bed rest phase, the volunteers had to remain in the head down position (6° below the horizontal) without getting up, neither for meals nor for washing. Only those movements that kept the body axis in this position were allowed. In addition to the tests, the volunteers' days were also interspersed with leisure time. Volunteers were given access to television, internet or telephone to talk to their relatives and friends. They also had the opportunity to take language classes, enjoy beauty treatments... and even had a visit from Claudie Haigneré, astronaut and former Minister for European Affairs, and Jean-François Clervoy and Pedro Duque, astronauts.
During the 20 days following the bed rest phase, the volunteers underwent tests identical to the first phase, the results of which were compared with reference data.

 
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For more information
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They took up the weightlessness challenge - Article ESA
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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2015
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Ended
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Study of the effects of spaceflight on the human body
Study of dry immersion as a simulation model
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CNES
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Unique in Europe ! 
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MEDES has conducted a clinical study on behalf of CNES. The objective was to study a ground simulation model called "dry immersion" concerning the effects of weightlessness. 
This was the very first study using the dry immersion model in Europe !
The model was developed and used by Russian scientists. Until now, it had not been truly studied in Europe, where the "bed rest" model is more commonly used. MEDES has already carried out many studies of this type, testing prevention methods such as exercise, adapted nutrition, a drug solution, artificial gravity, vibration exercises, etc.
 
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This new "dry immersion" model seemed interesting because it apparently induces certain physiological effects that the bed-rest model cannot faithfully reproduce and would therefore complement the latter.
The key advantage of dry immersion is its ability to simulate a support-free environment; the support is spread uniformly across the whole body area. The human body interprets dry immersion as being free of any kind of support, a situation comparable to that of real microgravity. The other factors acting simultaneously on the human body during immersion are linked to the lack of virtually all physical activity, due to a decrease in movements, the absence of body weight and the pressure of the water. The dry immersion model also makes it possible to quickly reproduce the effects of weightlessness on the sensory, motor and cardiovascular systems.
The CNES therefore decided to carry out this initial study – considered as a pilot study – to assess the effects of this model and its value.
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How the study was conducted
 
The subjects were installed in a sort of bath (2.10m x 1.10m x 0.85m) that had been specially designed for this use and filled with water. A special elastic waterproof fabric was fixed on the outside edge of the tub to stop the subjects from touching the water.
The study was conducted in February 2015, on the premises of the Space Clinic. Twelve healthy, male volunteers (aged between 20 and 45) took part  in the study.
Each of the subjects remained "immersed" for 3 days. In addition to this, the volunteers spent 3 days having basic measurements carried out beforehand and then a further 2 days post-immersion in order for comparative measurement to be conducted and to allow them to recover.
Many measurement and evaluations were carried out during the study. They can be put into two categories:

Standard tests (called Baseline Core Data), which are carried out in all studies of this type,
The tests provided for in the scientific protocols.
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This study, the first of its kind, marked the use of this new weightlessness simulation model for the CNES and then for the ESA, whose recent studies have been carried out.
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Nos actualités
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Nos projets
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Une question ?
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Devenir volontaire ?
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Nos études cliniques
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Urgent ! Recrutement volontaires
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