{"id":13217,"date":"2021-12-01T09:18:37","date_gmt":"2021-12-01T08:18:37","guid":{"rendered":"https:\/\/www.medes.fr\/project\/bed-rest-study-cocktail-2017\/"},"modified":"2023-06-05T10:37:48","modified_gmt":"2023-06-05T08:37:48","slug":"bed-rest-study-cocktail-2017","status":"publish","type":"project","link":"https:\/\/www.medes.fr\/en\/project\/bed-rest-study-cocktail-2017\/","title":{"rendered":"Bed rest study “Cocktail” (2017)"},"content":{"rendered":"

[et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.18.0″ _module_preset=”default” background_enable_color=”off” background_image=”https:\/\/www.medes.fr\/wp-content\/uploads\/2022\/06\/AdobeStock_279577524-compressed-scaled.jpg” custom_padding=”40px||40px||true|false” custom_padding_tablet=”30px||30px||true|false” custom_padding_phone=”30px||30px||false|false” locked=”off” global_colors_info=”{}” custom_css_after_last_edited=”off|desktop”][et_pb_row _builder_version=”4.18.0″ _module_preset=”default” custom_margin=”|auto|40px|auto|false|false” custom_margin_tablet=”||30px||false|false” custom_margin_phone=”||30px||false|false” custom_margin_last_edited=”on|phone” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.17.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.21.0″ _dynamic_attributes=”content” _module_preset=”default” text_orientation=”center” custom_margin=”||14px||false|false” custom_padding=”||0px|||” header_text_align_tablet=”” header_text_align_phone=”left” header_text_align_last_edited=”on|phone” global_colors_info=”{}”]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF90aXRsZSIsInNldHRpbmdzIjp7ImJlZm9yZSI6IjxoMT4iLCJhZnRlciI6IjwvaDE+In19@[\/et_pb_text][et_pb_divider color=”#ffae00″ divider_weight=”5px” _builder_version=”4.18.0″ _module_preset=”default” width=”300px” width_tablet=”250px” width_phone=”150px” width_last_edited=”on|phone” module_alignment=”center” custom_margin=”||0px||false|false” custom_padding=”||2px||false|false” module_alignment_tablet=”center” module_alignment_phone=”left” module_alignment_last_edited=”on|phone” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text module_class=”projectCategorie” _builder_version=”4.18.0″ _dynamic_attributes=”content” _module_preset=”default” text_font_size=”14px” link_text_color=”#444444″ text_orientation=”center” text_orientation_tablet=”center” text_orientation_phone=”left” text_orientation_last_edited=”on|phone” global_colors_info=”{}” link_text_color__hover_enabled=”on|hover” link_text_color__hover=”#115894″]@ET-DC@eyJkeW5hbWljIjp0cnVlLCJjb250ZW50IjoicG9zdF9jYXRlZ29yaWVzIiwic2V0dGluZ3MiOnsiYmVmb3JlIjoiIiwiYWZ0ZXIiOiIiLCJsaW5rX3RvX3Rlcm1fcGFnZSI6Im9uIiwic2VwYXJhdG9yIjoiICIsImNhdGVnb3J5X3R5cGUiOiJwcm9qZWN0X2NhdGVnb3J5In19@[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” module_class=”rowDetails” _builder_version=”4.18.0″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}” custom_css_main_element_last_edited=”off|phone”][et_pb_blurb title=”Date : ” use_icon=”on” font_icon=”||fa||400″ icon_color=”#115894″ icon_placement=”left” image_icon_width=”30px” image_icon_width_tablet=”28px” image_icon_width_phone=”25px” image_icon_width_last_edited=”on|phone” _builder_version=”4.18.0″ _module_preset=”default” header_text_color=”#444444″ animation=”off” global_colors_info=”{}”]<\/p>\n

2021<\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”State of progress :” use_icon=”on” font_icon=”||fa||400″ icon_color=”#115894″ icon_placement=”left” image_icon_width=”30px” image_icon_width_tablet=”28px” image_icon_width_phone=”25px” image_icon_width_last_edited=”on|phone” _builder_version=”4.21.0″ _module_preset=”default” header_text_color=”#444444″ animation=”off” locked=”off” global_colors_info=”{}”]<\/p>\n

Ended<\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Objective : ” use_icon=”on” font_icon=”||fa||900″ icon_color=”#115894″ icon_placement=”left” image_icon_width=”30px” image_icon_width_tablet=”28px” image_icon_width_phone=”25px” image_icon_width_last_edited=”on|phone” _builder_version=”4.21.0″ _module_preset=”default” header_text_color=”#444444″ animation=”off” locked=”off” global_colors_info=”{}”]<\/p>\n

Study of the effects of space flight on the human body<\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Partner : ” use_icon=”on” font_icon=”||fa||400″ icon_color=”#115894″ icon_placement=”left” image_icon_width=”30px” image_icon_width_tablet=”28px” image_icon_width_phone=”25px” image_icon_width_last_edited=”on|phone” _builder_version=”4.21.0″ _module_preset=”default” header_text_color=”#444444″ animation=”off” locked=”off” global_colors_info=”{}”]<\/p>\n

ESA<\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.18.0″ _module_preset=”default” custom_padding=”60px||60px||true|false” custom_padding_tablet=”40px||40px||true|false” custom_padding_phone=”30px||30px||true|false” global_colors_info=”{}”][et_pb_row _builder_version=”4.18.0″ _module_preset=”default” custom_margin=”||10px||false|false” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”MEDES a men\u00e9 pour l’ESA” _builder_version=”4.21.0″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” locked=”off” global_colors_info=”{}”]<\/p>\n

Weightlessness simulation study carried out in 2017<\/h2>\n

[\/et_pb_text][et_pb_text admin_label=”MEDES a men\u00e9 pour l’ESA” _builder_version=”4.20.2″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” locked=”off” global_colors_info=”{}”]<\/p>\n

For the purposes of space-related medical research, ten male volunteers are taking part in an extraordinary experiment at the MEDES Space Clinic:\u00a0<\/span>simulating and studying the effects of\u00a0<\/span><\/strong>weightlessness<\/strong>\u00a0<\/span>on the human body!<\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ use_custom_gutter=”on” make_equal=”on” _builder_version=”4.19.1″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”2_3″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=”margin-bottom: 30px !important” custom_css_main_element_phone=”margin-bottom: 30px !important”][et_pb_text admin_label=”Au dernier trimestre 2021″ _builder_version=”4.20.2″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” locked=”off” global_colors_info=”{}”]<\/p>\n

Called “Cocktail,” the study is sponsored by CNES and ESA. It will last 3 months (including 60 days in bed) and take place over 2 campaigns, each involving 10 volunteers : from January to April and then from September to December 2017.<\/strong><\/p>\n

The aim of the study is to simulate <\/span>conditions similar to those on manned space flights<\/strong>\u00a0in order to test a prevention method intended to mitigate the adverse effects of weightlessness on the human body and prepare astronauts for their return to Earth.<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.19.1″ _module_preset=”default” background_enable_image=”off” global_colors_info=”{}”][et_pb_image src=”https:\/\/www.medes.fr\/wp-content\/uploads\/2022\/11\/Capture-decran-2022-11-30-151615.png” alt=”Etude d’immersion s\u00e8che f\u00e9minine – 2021″ title_text=”Etude d’immersion s\u00e8che f\u00e9minine – 2021″ force_fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.20.2″ _module_preset=”default” use_background_color_gradient=”on” background_color_gradient_stops=”#256c9e 0%|#1a5d90 100%” custom_padding=”60px||60px||true|false” custom_padding_tablet=”40px||40px||true|false” custom_padding_phone=”40px||40px||true|false” global_colors_info=”{}”][et_pb_row column_structure=”1_3,2_3″ use_custom_gutter=”on” make_equal=”on” _builder_version=”4.19.1″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.19.1″ _module_preset=”default” background_enable_image=”off” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_phone=”margin-bottom: 30px !important”][et_pb_image src=”https:\/\/www.medes.fr\/wp-content\/uploads\/2022\/11\/D.png” alt=”Une journ\u00e9e en immersion” title_text=”Une journ\u00e9e en immersion” force_fullwidth=”on” disabled_on=”off|off|off” _builder_version=”4.20.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”2_3″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Au dernier trimestre 2021″ _builder_version=”4.20.2″ text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” locked=”off” global_colors_info=”{}”]<\/p>\n

Prevention method<\/h2>\n

This method consists of an antioxidant and anti-inflammatory food supplement (a mixture of natural polyphenolic extracts from edible plants) that the volunteers will have to take several times a day in the form of capsules. Half of the volunteers will take the food supplement and the other half will be used as a control group, which does not therefore take the cocktail of capsules.<\/p>\n

16 European scientific teams are taking part in the experiment<\/strong>. They are interested in studying the changes induced by bed rest and the effects of the prevention method, which will be tested in the following areas: the metabolism, the cardiovascular system, muscles, bones, immunology, the neurosensory system and sleep.<\/p>\n

The study lasts 3 months and takes place in 3 phases:<\/p>\n

    \n
  • 15 days of measurements<\/strong>\u00a0<\/span>on each volunteer before the bed rest<\/li>\n
  • 2 months of anti-orthostatic bed rest tilted at -6\u00b0 (the head lower than the feet)<\/strong><\/li>\n
  • 15 days of recovery<\/strong>\u00a0<\/span>during which new post-bed-rest measurements are collected making it possible to study the effects on the body of bed rest and the counter-measures by comparing them with the measurements made before the bed rest.<\/li>\n<\/ul>\n
      <\/ul>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.18.0″ _module_preset=”default” custom_padding=”60px||60px||true|false” custom_padding_tablet=”40px||40px||true|false” custom_padding_phone=”30px||30px||true|false” locked=”off” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” make_equal=”on” custom_padding_last_edited=”off|tablet” _builder_version=”4.18.0″ _module_preset=”default” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}” custom_css_main_element_last_edited=”on|tablet” custom_css_main_element_tablet=”margin-bottom: 30px !important;” custom_css_main_element_phone=”margin-bottom: 30px !important;”][et_pb_text admin_label=”Pourquoi une immersion s\u00e8che ?” _builder_version=”4.21.0″ header_2_text_align=”right” background_size=”initial” background_position=”top_left” background_repeat=”repeat” text_orientation=”right” header_2_text_align_tablet=”left” header_2_text_align_phone=”left” header_2_text_align_last_edited=”on|tablet” text_orientation_tablet=”left” text_orientation_phone=”left” text_orientation_last_edited=”on|tablet” locked=”off” global_colors_info=”{}”]<\/p>\n

      While this research is very useful for advancing space research, it also valuable for medicine on Earth. Indeed, subjecting healthy subjects to long periods of immobilisation with no physical activity allows scientists to have a better understanding of certain diseases such as obesity, diabetes or osteoporosis.<\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ custom_padding_last_edited=”on|phone” _builder_version=”4.19.1″ _module_preset=”default” custom_padding=”60px||60px||true|false” custom_padding_tablet=”40px||40px||true|false” custom_padding_phone=”30px||30px||true|false” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” make_equal=”on” _builder_version=”4.19.1″ _module_preset=”default” custom_margin=”-55px||||false|false” custom_padding=”0px||0px||true|false” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.19.1″ _module_preset=”default” background_enable_image=”off” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone” custom_css_main_element_phone=”margin-bottom: 30px !important”][et_pb_text admin_label=”Au dernier trimestre 2021″ _builder_version=”4.21.0″ text_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”|21px|||false|false” hover_enabled=”0″ border_width_all=”8px” border_color_all=”RGBA(255,255,255,0)” border_color_right=”#256c9e” locked=”off” global_colors_info=”{}” sticky_enabled=”0″]<\/p>\n

      Why bed rest at -6\u00b0?<\/span><\/h2>\n

      After several decades of practical studies, it has been determined that a -6\u00b0 tilt (feet slightly above the head) corresponds to what an astronaut\u2019s body experiences in a situation ofweightlessness. This position causes the bodily fluids to move to the upper part of the body, as observed in space. This makes it possible to simulate weightlessness while keeping the subject\u2019s feet (almost) on Earth!<\/span><\/span><\/p>\n

      [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ module_class=”sectionFixe” _builder_version=”4.18.0″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” positioning=”none” position_origin_f=”center_right” horizontal_offset=”0px” custom_padding=”0px||0px||true|false” custom_css_main_element=”position: fixed !important;||right: 0 !important;||left: unset !important;||top: 57%!important;||transform: translateY(-50%);” locked=”off” global_colors_info=”{}”][et_pb_row use_custom_gutter=”on” gutter_width=”1″ make_equal=”on” _builder_version=”4.18.0″ _module_preset=”default” width=”100%” max_width=”100%” custom_padding=”0px||0px||true|false” custom_css_main_element=” overflow: visible !important;” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_blurb image=”https:\/\/www.medes.fr\/wp-content\/uploads\/2023\/04\/Sans-titre-18.png” icon_placement=”left” image_icon_width=”50px” module_class=”boutonFixe” _builder_version=”4.20.2″ _module_preset=”default” background_color=”#ffae00″ image_icon_custom_margin=”||||false|false” image_icon_custom_padding=”|14px|||false|false” custom_padding=”10px|10px|10px|10px|true|true” animation=”off” link_option_url=”https:\/\/www.medes.fr\/en\/ressources\/news\/” global_colors_info=”{}”]<\/p>\n

      Nos actualit\u00e9s<\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” image_icon_width=”30px” module_class=”boutonFixe” _builder_version=”4.20.2″ _module_preset=”default” background_color=”#D6D6D6″ custom_padding=”10px|10px|10px|10px|true|true” animation=”off” link_option_url=”https:\/\/www.medes.fr\/en\/our-projects\/” global_colors_info=”{}”]<\/p>\n

      Nos projets<\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”u||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” image_icon_width=”30px” module_class=”boutonFixe” _builder_version=”4.20.2″ _module_preset=”default” background_color=”#5e5e5e” custom_padding=”10px|10px|10px|10px|true|true” animation=”off” link_option_url=”https:\/\/www.medes.fr\/en\/contact\/” global_colors_info=”{}”]<\/p>\n

      Une question ?<\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”||fa||400″ icon_color=”#FFFFFF” icon_placement=”left” image_icon_width=”30px” module_class=”boutonFixe” _builder_version=”4.20.2″ _module_preset=”default” background_color=”gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982″ custom_padding=”10px|10px|10px|10px|true|true” animation=”off” link_option_url=”https:\/\/www.medes.fr\/en\/space-clinic\/become-a-volunteer\/” global_colors_info=”{%22gcid-54b54a1e-9ad0-4545-b0eb-2cf1c6cd3982%22:%91%22background_color%22%93}”]<\/p>\n

      Devenir volontaire ?<\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”||fa||400″ icon_color=”#FFFFFF” icon_placement=”left” image_icon_width=”30px” module_class=”boutonFixe” _builder_version=”4.19.5″ _module_preset=”default” background_color=”gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199″ custom_padding=”10px|10px|10px|10px|true|true” animation=”off” link_option_url=”https:\/\/www.medes.fr\/en\/space-clinic\/clinical-studies\/” global_colors_info=”{%22gcid-4eb119fd-82df-4fd0-ae59-ab7f1c508199%22:%91%22background_color%22%93}”]<\/p>\n

      Nos \u00e9tudes cliniques<\/p>\n

      [\/et_pb_blurb][et_pb_blurb use_icon=”on” font_icon=”s||divi||400″ icon_color=”#FFFFFF” icon_placement=”left” image_icon_width=”28px” module_class=”boutonFixe” _builder_version=”4.20.2″ _module_preset=”default” background_color=”#002130″ custom_padding=”10px|10px|10px|10px|true|true” animation=”off” link_option_url=”https:\/\/www.medes.fr\/a-la-une\/recrutement\/” global_colors_info=”{}”]<\/p>\n

      Urgent ! Recrutement volontaires<\/p>\n

      [\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

      MEDES has carried out a new ground-based study to simulate weightlessness. 20 volunteers took part in this long-term study, which was carried out in 2 phases: an initial campaign with 10 volunteers from January to April 2017 and a second campaign from September to December 2017.<\/p>\n","protected":false},"author":1,"featured_media":12661,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"project_category":[80,86,79,51,47,46,54,75,82],"project_tag":[],"class_list":["post-13217","project","type-project","status-publish","has-post-thumbnail","hentry","project_category-bed-rest-study","project_category-clinical-research","project_category-clinical-study","project_category-etude-clinique","project_category-etude-dalitement","project_category-etude-de-simulation-dimpesanteur","project_category-la-recherche-clinique","project_category-space-clinic","project_category-weightlessness-simulation-study"],"acf":[],"yoast_head":"\nBed rest study "Cocktail" (2017) - 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